Search Results - "CHAN, Stephen Y. T"

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers by Alblihy, Adel, Shoqafi, Ahmed, Toss, Michael S., Algethami, Mashael, Harris, Anna E., Jeyapalan, Jennie N., Abdel-Fatah, Tarek, Servante, Juliette, Chan, Stephen Y. T., Green, Andrew, Mongan, Nigel P., Rakha, Emad A., Madhusudan, Srinivasan

“…The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such…”
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RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer by ROBERT, Nicholas J, DIERAS, Véronique, PHAN, See-Chun, O'SHAUGHNESSY, Joyce, GLASPY, John, BRUFSKY, Adam M, BONDARENKO, Igor, LIPATOV, Oleg N, PEREZ, Edith A, YARDLEY, Denise A, CHAN, Stephen Y. T, XIAN ZHOU

“…This phase III study compared the efficacy and safety of bevacizumab (BV) when combined with several standard chemotherapy regimens versus those regimens alone…”
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Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy by Al-Subhi, Nouf, Ali, Reem, Abdel-Fatah, Tarek, Moseley, Paul M., Chan, Stephen Y. T., Green, Andrew R., Ellis, Ian O., Rakha, Emad A., Madhusudan, Srinivasan

“…Purpose Phosphate and tensin homolog (PTEN), a negative regulator of PI3K signaling, is involved in DNA repair. ATR is a key sensor of DNA damage and…”
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SHON Is a Novel Estrogen-Regulated Oncogene in Mammary Carcinoma That Predicts Patient Response to Endocrine Therapy by YEWON JUNG, ABDEL-FATAH, Tarek M. A, LONGXIN CHEN, MA, Runlin Z, MIN ZHANG, JINGRU WANG, ZHENGSHENG WU, TAO ZHU, PERRY, Jo K, LOBIE, Peter E, LIU, Dong-Xu, CHAN, Stephen Y. T, NOLAN, Christopher C, GREEN, Andrew R, ELLIS, Ian O, LILI LI, BAIQU HUANG, JUN LU, BING XU

“…Endocrine therapies are the primary systemic intervention for patients with estrogen receptor-positive (ER(+)) breast cancer. However, a significant proportion…”
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Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer by Foulds, Gemma A, Vadakekolathu, Jayakumar, Abdel-Fatah, Tarek M A, Nagarajan, Divya, Reeder, Stephen, Johnson, Catherine, Hood, Simon, Moseley, Paul M, Chan, Stephen Y T, Pockley, A Graham, Rutella, Sergio, McArdle, Stephanie E B

“…Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could…”
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Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer by Naidoo, Kalnisha, Wai, Patty T, Maguire, Sarah L, Daley, Frances, Haider, Syed, Kriplani, Divya, Campbell, James, Mirza, Hasan, Grigoriadis, Anita, Tutt, Andrew, Moseley, Paul M, Abdel-Fatah, Tarek M A, Chan, Stephen Y T, Madhusudan, Srinivasan, Rhaka, Emad A, Ellis, Ian O, Lord, Christopher J, Yuan, Yinyin, Green, Andrew R, Natrajan, Rachael

“…Disruption of Cyclin-Dependent Kinase 12 ( ) is known to lead to defects in DNA repair and sensitivity to platinum salts and PARP1/2 inhibitors. However, has…”
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SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment by Abdel-Fatah, Tarek M. A., Broom, Reuben J., Lu, Jun, Moseley, Paul M., Huang, Baiqu, Li, Lili, Liu, Suling, Chen, Longxin, Ma, Runlin Z., Cao, Wenming, Wang, Xiaojia, Li, Yan, Perry, Jo K., Aleskandarany, Mohammed, Nolan, Christopher C., Rakha, Emad A., Lobie, Peter E., Chan, Stephen Y. T., Ellis, Ian O., Hwang, Le-Ann, Lane, David P., Green, Andrew R., Liu, Dong-Xu

“…Background SHON nuclear expression (SHON-Nuc + ) was previously reported to predict clinical outcomes to tamoxifen therapy in ERα + breast cancer (BC). Herein…”
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Clinicopathological Significance of ATM-Chk2 Expression in Sporadic Breast Cancers: a Comprehensive Analysis in Large Cohorts by Abdel-Fatah, Tarek M.A, Arora, Arvind, Alsubhi, Nouf, Agarwal, Devika, Moseley, Paul M, Perry, Christina, Doherty, Rachel, Chan, Stephen Y.T, Green, Andrew R, Rakha, Emad, Ball, Graham, Ellis, Ian O, Madhusudan, Srinivasan

“…Abstract ATM-Chk2 network is critical for genomic stability, and its deregulation may influence breast cancer pathogenesis. We investigated ATM and Chk2…”
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SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis by Abdel-Fatah, Tarek M A, PhD, Agarwal, Devika, MSc, Liu, Dong-Xu, PhD, Russell, Roslin, PhD, Rueda, Oscar M, PhD, Liu, Karen, MSc, Xu, Bing, PhD, Moseley, Paul M, BSc, Green, Andrew R, PhD, Pockley, Alan G, Prof, Rees, Robert C, Prof, Caldas, Carlos, Prof, Ellis, Ian O, Prof, Ball, Graham R, Prof, Chan, Stephen Y T, Prof

“…Summary Background Proliferation markers and profiles have been recommended for guiding the choice of systemic treatments for breast cancer. However, the best…”
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RECQL4 helicase has oncogenic potential in sporadic breast cancers by Arora, Arvind, Agarwal, Devika, Abdel-Fatah, Tarek MA, Lu, Huiming, Croteau, Deborah L, Moseley, Paul, Aleskandarany, Mohammed A, Green, Andrew R, Ball, Graham, Rakha, Emad A, Chan, Stephen YT, Ellis, Ian O, Wang, Lisa L, Zhao, Yongliang, Balajee, Adayabalam S, Bohr, Vilhelm A, Madhusudan, Srinivasan

“…RECQL4 helicase is a molecular motor that unwinds DNA, a process essential during DNA replication and DNA repair. Germ‐line mutations in RECQL4 cause type II…”
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Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer by Abdel-Fatah, Tarek M A, Ball, Graham R, Thangavelu, Pulari U, Reid, Lynne E, McCart Reed, Amy E, Saunus, Jodi M, Duijf, Pascal H G, Simpson, Peter T, Lakhani, Sunil R, Pongor, Lorinc, Gyorffy, Balázs, Moseley, Paul M, Green, Andrew R, Pockley, Alan G, Caldas, Carlos, Ellis, Ian O, Chan, Stephen Y T

“…There is no proven test that can guide the optimal treatment, either endocrine therapy or chemotherapy, for estrogen receptor-positive breast cancer. To…”
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ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers by Mesquita, Katia A., Alabdullah, Muslim, Griffin, Michaela, Toss, Michael S., Fatah, Tarek M.A. Abdel, Alblihy, Adel, Moseley, Paul, Chan, Stephen Y.T., Rakha, Emad A., Madhusudan, Srinivasan

“…PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic…”
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Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers by Arora, Arvind, Abdel-Fatah, Tarek M A, Agarwal, Devika, Doherty, Rachel, Croteau, Deborah L, Moseley, Paul M, Hameed, Khalid, Green, Andrew, Aleskandarany, Mohammed A, Rakha, Emad A, Patterson, Karl, Ball, Graham, Chan, Stephen Y T, Ellis, Ian O, Bohr, Vilhelm A, Bryant, Helen E, Madhusudan, Srinivasan

“…RECQL5 is a member of the RecQ family of DNA helicases and has key roles in homologous recombination, base excision repair, replication and transcription. The…”
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Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer by Arora, Arvind, Abdel-Fatah, Tarek M A, Agarwal, Devika, Doherty, Rachel, Moseley, Paul M, Aleskandarany, Mohammed A, Green, Andrew R, Ball, Graham, Alshareeda, Alaa T, Rakha, Emad A, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Bloom syndrome helicase (BLM) has key roles in homologous recombination repair, telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene…”
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Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? by Abdel-Fatah, Tarek M A, Perry, Christina, Arora, Arvind, Thompson, Nicola, Doherty, Rachel, Moseley, Paul M, Green, Andrew R, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Estrogen and estrogen metabolite-induced reactive oxygen species generation can promote oxidative DNA base damage. If unrepaired, base damaging lesions could…”
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HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis by Abdel-Fatah, Tarek M A, McArdle, Stephanie E B, Agarwal, Devika, Moseley, Paul M, Green, Andrew R, Ball, Graham R, Pockley, A Graham, Ellis, Ian O, Rees, Robert C, Chan, Stephen Y T

“…The expression of HAGE as a novel prognostic and predictive tool was assessed in 1,079 triple-negative breast cancers (TNBC). HAGE protein expression was…”
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Nottingham Clinico-Pathological Response Index (NPRI) after neoadjuvant chemotherapy (Neo-ACT) accurately predicts clinical outcome in locally advanced breast cancer by Abdel-Fatah, Tarek M, Ball, Graham, Lee, Andrew H S, Pinder, Sarah, MacMilan, R Douglas, Cornford, Eleanor, Moseley, Paul M, Silverman, Rafael, Price, James, Latham, Bruce, Palmer, David, Chan, Arlene, Ellis, Ian O, Chan, Stephen Y T

“…There is a need to identify more sensitive clinicopathologic criteria to assess the response to neoadjuvant chemotherapy (Neo-ACT) and guide subsequent…”
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ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers by Abdel-Fatah, Tarek M A, Ali, Reem, Sadiq, Maaz, Moseley, Paul M, Mesquita, Katia A, Ball, Graham, Green, Andrew R, Rakha, Emad A, Chan, Stephen Y T, Madhusudan, Srinivasan

“…Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated 188 DNA repair genes in the METABRIC cohort ( =…”
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DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers by Abdel-Fatah, Tarek M A, Arora, Arvind, Moseley, Paul M, Perry, Christina, Rakha, Emad A, Green, Andrew R, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Stratification of oestrogen receptor (ER) negative and triple negative breast cancers (TNBCs) is urgently needed. In the current study, a cohort of 880 ER-…”
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The localization of pre mRNA splicing factor PRPF38B is a novel prognostic biomarker that may predict survival benefit of trastuzumab in patients with breast cancer overexpressing HER2 by Abdel-Fatah, Tarek M A, Rees, Robert C, Pockley, A Graham, Moseley, Paul, Ball, Graham R, Chan, Stephen Y T, Ellis, Ian O, Miles, Amanda K

“…Cancer biomarkers that can define disease status and provide a prognostic insight are essential for the effective management of patients with breast cancer…”
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