Search Results - "CHAN, Robin B"

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures by Miranda, André Miguel Lopes, Lasiecka, Zofia M., Xu, Yimeng, Neufeld, Jessi, Shahriar, Sanjid, Simoes, Sabrina, Chan, Robin B., Oliveira, Tiago Gil, Small, Scott A., Di Paolo, Gilbert

“…Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders. A master regulator of…”
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Metabolic activity induces membrane phase separation in endoplasmic reticulum by Shen, Yihui, Zhao, Zhilun, Zhang, Luyuan, Shi, Lingyan, Shahriar, Sanjid, Chan, Robin B., Di Paolo, Gilbert, Min, Wei

“…Membrane phase behavior has been well characterized in model membranes in vitro under thermodynamic equilibrium state. However, the widely observed differences…”
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Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast by Vevea, Jason D., Garcia, Enrique J., Chan, Robin B., Zhou, Bowen, Schultz, Mei, Di Paolo, Gilbert, McCaffery, J. Michael, Pon, Liza A.

“…The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are altered phospholipid levels, slow growth, and defects in the…”
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Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease by Pera, Marta, Larrea, Delfina, Guardia‐Laguarta, Cristina, Montesinos, Jorge, Velasco, Kevin R, Agrawal, Rishi R, Xu, Yimeng, Chan, Robin B, Di Paolo, Gilbert, Mehler, Mark F, Perumal, Geoffrey S, Macaluso, Frank P, Freyberg, Zachary Z, Acin‐Perez, Rebeca, Enriquez, Jose Antonio, Schon, Eric A, Area‐Gomez, Estela

“…In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa…”
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Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation by Quon, Evan, Sere, Yves Y, Chauhan, Neha, Johansen, Jesper, Sullivan, David P, Dittman, Jeremy S, Rice, William J, Chan, Robin B, Di Paolo, Gilbert, Beh, Christopher T, Menon, Anant K

“…Tether proteins attach the endoplasmic reticulum (ER) to other cellular membranes, thereby creating contact sites that are proposed to form platforms for…”
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Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis by Chan, Robin B, Perotte, Adler J, Zhou, Bowen, Liong, Christopher, Shorr, Evan J, Marder, Karen S, Kang, Un J, Waters, Cheryl H, Levy, Oren A, Xu, Yimeng, Shim, Hong Bin, Pe'er, Itsik, Di Paolo, Gilbert, Alcalay, Roy N

“…Parkinson's disease (PD) is a common neurodegenerative disease whose pathological hallmark is the accumulation of intracellular α-synuclein aggregates in Lewy…”
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum by Gulati, Sonia, Ekland, Eric H., Ruggles, Kelly V., Chan, Robin B., Jayabalasingham, Bamini, Zhou, Bowen, Mantel, Pierre-Yves, Lee, Marcus C.S., Spottiswoode, Natasha, Coburn-Flynn, Olivia, Hjelmqvist, Daisy, Worgall, Tilla S., Marti, Matthias, Di Paolo, Gilbert, Fidock, David A.

“…During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids. Consistent…”
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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system by Morel, Etienne, Chamoun, Zeina, Lasiecka, Zofia M., Chan, Robin B., Williamson, Rebecca L., Vetanovetz, Christopher, Dall’Armi, Claudia, Simoes, Sabrina, Point Du Jour, Kimberly S., McCabe, Brian D., Small, Scott A., Di Paolo, Gilbert

“…Defects in endosomal sorting have been implicated in Alzheimer’s disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a…”
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Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits by Oliveira, Tiago Gil, Chan, Robin B, Tian, Huasong, Laredo, Mikael, Shui, Guanghou, Staniszewski, Agnieszka, Zhang, Hong, Wang, Lili, Kim, Tae-Wan, Duff, Karen E, Wenk, Markus R, Arancio, Ottavio, Di Paolo, Gilbert

“…Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions…”
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HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels by Holland, Petter, Knævelsrud, Helene, Søreng, Kristiane, Mathai, Benan J., Lystad, Alf Håkon, Pankiv, Serhiy, Bjørndal, Gunnveig T., Schultz, Sebastian W., Lobert, Viola H., Chan, Robin B., Zhou, Bowen, Liestøl, Knut, Carlsson, Sven R., Melia, Thomas J., Di Paolo, Gilbert, Simonsen, Anne

“…A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome…”
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Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity by Agarwal, Shivani, Kim, Hyunjin, Chan, Robin B., Agarwal, Shivangi, Williamson, Rebecca, Cho, Wonhwa, Di Paolo, Gilbert, Satchell, Karla J. F.

“…Vibrio cholerae , responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host…”
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The phospholipase D1 pathway modulates macroautophagy by Di Paolo, Gilbert, Dall'Armi, Claudia, Hurtado-Lorenzo, Andrés, Tian, Huasong, Morel, Etienne, Nezu, Akiko, Chan, Robin B, Yu, W. Haung, Robinson, Kimberly S, Yeku, Oladapo, Small, Scott A, Duff, Karen, Frohman, Michael A, Wenk, Markus R, Yamamoto, Akitsugu

“…Although macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic components…”
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Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms by Mitchell, Emma, Klein, Shifra L., Argyropoulos, Kimon V., Sharma, Ali, Chan, Robin B., Toth, Judit Gal, Barboza, Luendreo, Bavley, Charlotte, Bortolozzi, Analia, Chen, Qiuying, Liu, Bingfang, Ingenito, Joanne, Mark, Willie, Dudakov, Jarrod, Gross, Steven, Di Paolo, Gilbert, Artigas, Francesc, van den Brink, Marcel, Toth, Miklos

“…Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. Although trait transmission via sperm has been extensively…”
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Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization[S] by Roach, Akua N., Wang, Ziqing, Wu, Ping, Zhang, Feng, Chan, Robin B., Yonekubo, Yoshiya, Di Paolo, Gilbert, Gorfe, Alemayehu A., Du, Guangwei

“…Type I phosphatidylinositol-4-phosphate 5-kinase (PIPKI) is the main enzyme generating the lipid second messenger phosphatidylinositol-4,5-bisphosphate…”
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Implications for lipids during replication of enveloped viruses by Chan, Robin B., Tanner, Lukas, Wenk, Markus R.

“…Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are…”
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Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease by Chan, Robin B., Oliveira, Tiago G., Cortes, Etty P., Honig, Lawrence S., Duff, Karen E., Small, Scott A., Wenk, Markus R., Shui, Guanghou, Di Paolo, Gilbert

“…Lipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer disease (AD). Here, a…”
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Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption by Bertaggia, Enrico, Jensen, Kristian K, Castro-Perez, Jose, Xu, Yimeng, Di Paolo, Gilbert, Chan, Robin B, Wang, Liangsu, Haeusler, Rebecca A

“…Bile acids (BAs) are cholesterol derivatives that regulate lipid metabolism, through their dual abilities to promote lipid absorption and activate BA…”
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Remodeling of the postsynaptic plasma membrane during neural development by Tulodziecka, Karolina, Diaz-Rohrer, Barbara B, Farley, Madeline M, Chan, Robin B, Di Paolo, Gilbert, Levental, Kandice R, Waxham, M Neal, Levental, Ilya

“…Neuronal synapses are the fundamental units of neural signal transduction and must maintain exquisite signal fidelity while also accommodating the plasticity…”
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Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission by CHANG-HETO, Belle, FRERE, Samuel G, CHAN, Robin B, VORONOV, Sergey V, ROUX, Aurélien, DI PAOLO, Gilbert

“…Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P₂] plays a fundamental role in clathrin-mediated endocytosis. However, precisely how PI(4,5)P₂ metabolism is…”
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α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2 by Kett, Lauren R, Stiller, Barbara, Bernath, Megan M, Tasset, Inmaculada, Blesa, Javier, Jackson-Lewis, Vernice, Chan, Robin B, Zhou, Bowen, Di Paolo, Gilbert, Przedborski, Serge, Cuervo, Ana Maria, Dauer, William T

“…Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key feature in the pathogenesis of…”
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