Search Results - "CHAN, Rebecca J"

Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis by Daver, Naval G, Iqbal, Shahed, Renard, Camille, Chan, Rebecca J, Hasegawa, Ken, Hu, Hao, Tse, Preston, Yan, Jiajun, Zoratti, Michael J, Xie, Feng, Ramsingh, Giridharan

“…TP53 mutations, which are present in 5% to 10% of patients with acute myeloid leukemia (AML), are associated with treatment resistance and poor outcomes…”
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Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice by Farrow, Emily G, Yu, Xijie, Summers, Lelia J, Davis, Siobhan I, Fleet, James C, Allen, Matthew R, Robling, Alexander G, Stayrook, Keith R, Jideonwo, Victoria, Magers, Martin J, Garringer, Holly J, Vidal, Ruben, Chan, Rebecca J, Goodwin, Charles B, Hui, Siu L, Peacock, Munro, White, Kenneth E

“…Autosomal dominant hypophosphatemic rickets (ADHR) is unique among the disorders involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W…”
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Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents by Zhou, Bo, He, Yantao, Zhang, Xian, Xu, Jie, Luo, Yong, Wang, Yuehong, Franzblau, Scott G, Yang, Zhenyun, Chan, Rebecca J, Liu, Yan, Zheng, Jianyu, Zhang, Zhong-Yin

“…Protein tyrosine phosphatases are often exploited and subverted by pathogenic bacteria to cause human diseases. The tyrosine phosphatase mPTPB from…”
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Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase by Zeng, Li-Fan, Zhang, Ruo-Yu, Yu, Zhi-Hong, Li, Sijiu, Wu, Li, Gunawan, Andrea M, Lane, Brandon S, Mali, Raghuveer S, Li, Xingjun, Chan, Rebecca J, Kapur, Reuben, Wells, Clark D, Zhang, Zhong-Yin

“…The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase associated with various kinds of leukemia and solid…”
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Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow by Clinkenbeard, Erica L, Hanudel, Mark R, Stayrook, Keith R, Appaiah, Hitesh Nidumanda, Farrow, Emily G, Cass, Taryn A, Summers, Lelia J, Ip, Colin S, Hum, Julia M, Thomas, Joseph C, Ivan, Mircea, Richine, Briana M, Chan, Rebecca J, Clemens, Thomas L, Schipani, Ernestina, Sabbagh, Yves, Xu, Linlin, Srour, Edward F, Alvarez, Marta B, Kacena, Melissa A, Salusky, Isidro B, Ganz, Tomas, Nemeth, Elizabeta, White, Kenneth E

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Systemic and cerebral iron homeostasis in ferritin knock-out mice by Li, Wei, Garringer, Holly J, Goodwin, Charles B, Richine, Briana, Acton, Anthony, VanDuyn, Natalia, Muhoberac, Barry B, Irimia-Dominguez, Jose, Chan, Rebecca J, Peacock, Munro, Nass, Richard, Ghetti, Bernardino, Vidal, Ruben

“…Ferritin, a 24-mer heteropolymer of heavy (H) and light (L) subunits, is the main cellular iron storage protein and plays a pivotal role in iron homeostasis by…”
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Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) by Zhang, Xian, He, Yantao, Liu, Sijiu, Yu, Zhihong, Jiang, Zhong-Xing, Yang, Zhenyun, Dong, Yuanshu, Nabinger, Sarah C, Wu, Li, Gunawan, Andrea M, Wang, Lina, Chan, Rebecca J, Zhang, Zhong-Yin

“…The Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) plays a pivotal role in growth factor and cytokine signaling. Gain-of-function SHP2…”
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p53 Is Renoprotective after Ischemic Kidney Injury by Reducing Inflammation by SUTTON, Timothy A, HATO, Takashi, MAI, Erik, YOSHIMOTO, Momoko, KUEHL, Sarah, ANDERSON, Melissa, MANG, Henry, PLOTKIN, Zoya, CHAN, Rebecca J, DAGHER, Pierre C

“…In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition of p53 is protective in this setting, but chronic inhibition…”
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Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL by Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben

“…We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL, which is dependent on PI3K and Rho GTPase…”
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Wnt Signaling Promotes Neuronal Differentiation from Mesenchymal Stem Cells Through Activation of Tlx3 by Kondo, Takako, Matsuoka, Akihiro J., Shimomura, Atsushi, Koehler, Karl R., Chan, Rebecca J., Miller, Josef M., Srour, Edward F., Hashino, Eri

“…Wnt/β‐catenin signaling promotes neural differentiation by activation of the neuron‐specific transcription factors, Neurogenin1 (Ngn1), NeuroD, and Brn3a, in…”
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Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis by Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Mali, Raghuveer Singh, Martin, Holly, Kobayashi, Michihiro, Vemula, Sasidhar, Canela, Victor H., Waskow, Emily R., Visconte, Valeria, Tiu, Ramon V., Smith, Catherine C., Shah, Neil, Bunting, Kevin D., Boswell, H. Scott, Liu, Yan, Chan, Rebecca J., Kapur, Reuben

“…Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms…”
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Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy by Garringer, Holly J, Irimia, Jose M, Li, Wei, Goodwin, Charles B, Richine, Briana, Acton, Anthony, Chan, Rebecca J, Peacock, Munro, Muhoberac, Barry B, Ghetti, Bernardino, Vidal, Ruben

“…Mutations in the ferritin light chain (FTL) gene cause the neurodegenerative disease neuroferritinopathy or hereditary ferritinopathy (HF). HF is characterized…”
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Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4 by Li, Yanjun, McClintick, Jeanette, Zhong, Li, Edenberg, Howard J., Yoder, Mervin C., Chan, Rebecca J.

“…Embryonic stem (ES) cells homozygous for a Shp-2 mutation (Shp-2Δ46-110) demonstrate leukemia inhibitory factor (LIF) hypersensitivity and increased…”
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Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst by Li, Xing Jun, Goodwin, Charles B, Nabinger, Sarah C., Richine, Briana M., Yang, Zhenyun, Hanenberg, Helmut, Ohnishi, Hiroshi, Matozaki, Takashi, Feng, Gen-Sheng, Chan, Rebecca J.

“…Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of…”
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Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT by Mali, Raghuveer Singh, Ma, Peilin, Zeng, Li-Fan, Martin, Holly, Ramdas, Baskar, He, Yantao, Sims, Emily, Nabinger, Sarah, Ghosh, Joydeep, Sharma, Namit, Munugalavadla, Veerendra, Chatterjee, Anindya, Li, Shuo, Sandusky, George, Craig, Andrew W., Bunting, Kevin D., Feng, Gen-Sheng, Chan, Rebecca J., Zhang, Zhong-Yin, Kapur, Reuben

“…Intracellular mechanism(s) that contribute to promiscuous signaling via oncogenic KIT in systemic mastocytosis and acute myelogenous leukemia are poorly…”
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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor by Chan, Rebecca J., Leedy, Melissa B., Munugalavadla, Veerendra, Voorhorst, Cara S., Li, Yanjun, Yu, Menggang, Kapur, Reuben

“…Juvenile myelomonocytic leukemia (JMML) is a lethal disease of young children characterized by hypersensitivity of hematopoietic progenitors to…”
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Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice by Tarnawsky, Stefan P, Yu, Wen-Mei, Qu, Cheng-Kui, Chan, Rebecca J, Yoder, Mervin C

“…Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. Somatic mutations in Ptpn11 are the most…”
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Negative Regulation of Stat3 by Activating PTPN11 Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia by Zhang, Wenjun, Chan, Rebecca J., Chen, Hanying, Yang, Zhenyun, He, Yantao, Zhang, Xian, Luo, Yong, Yin, Fuqing, Moh, Akira, Miller, Lucy C., Payne, R. Mark, Zhang, Zhong-Yin, Fu, Xin-Yuan, Shou, Weinian

“…Noonan syndrome (NS) is an autosomal dominant congenital disorder characterized by multiple birth defects including heart defects and myeloproliferative…”
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The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor by Ma, Peilin, Mali, Raghuveer Singh, Munugalavadla, Veerendra, Krishnan, Subha, Ramdas, Baskar, Sims, Emily, Martin, Holly, Ghosh, Joydeep, Li, Shuo, Chan, Rebecca J., Krystal, Gerald, Craig, Andrew W., Takemoto, Clifford, Kapur, Reuben

“…Mast cell maturation is poorly understood. We show that enhanced PI3K activation results in accelerated maturation of mast cells by inducing the expression of…”
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Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF by GOODWIN, Charles B, ZHENYUNYANG, FUQIN YIN, MENGGANGYU, CHAN, Rebecca J

“…Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte…”
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