Search Results - "CHAN, Howard"

Thromboembolic Risks with Concurrent Direct Oral Anticoagulants and Antiseizure Medications: A Population-Based Analysis by Ip, Bonaventure Y., Ko, Ho, Wong, Grace LH, Yip, Terry CF, Lau, Louis HS, Lau, Alexander YL, Leng, Xinyi, Leung, Howan, Chan, Howard HW, Chan, Helen YF, Mok, Vincent CT, Soo, Yannie OY, Leung, Thomas W.

“…Background and Objective Drug–drug interactions between direct oral anticoagulants (DOAC) and antiseizure medications via the cytochrome P450 (CYP) or the…”
Get full text

Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment[S] by Nguyen, Elizabeth V., Pereira, Brooke A., Lawrence, Mitchell G., Ma, Xiuquan, Rebello, Richard J., Chan, Howard, Niranjan, Birunthi, Wu, Yunjian, Ellem, Stuart, Guan, Xiaoqing, Wu, Jianmin, Skhinas, Joanna N., Cox, Thomas R., Risbridger, Gail P., Taylor, Renea A., Lister, Natalie L., Daly, Roger J.

“…Mass spectrometry-based (phospho)proteomics identified a prominent hub associated with collagens, receptor tyrosine kinase discoidin domain-containing receptor…”
Get full text

FGFR3 signaling and function in triple negative breast cancer by Chew, Nicole J, Nguyen, Elizabeth V, Su, Shih-Ping, Novy, Karel, Chan, Howard C, Nguyen, Lan K, Luu, Jennii, Simpson, Kaylene J, Lee, Rachel S, Daly, Roger J

“…Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this…”
Get full text

Effect of unfractionated heparin and low molecular weight heparin on the clotting of platelet-reduced whole blood: an in-vitro study utilizing thromboelastography by Chung, Jason, Stevic, Ivan, Gantioqui, Jorell, Atkinson, Helen, Chan, Anthony K.C., Chan, Howard H.W.

“…Treatment of venous thromboembolism with concomitant thrombocytopenia is challenging. The platelet threshold for safe administration of anticoagulants is under…”
Get full text

Potential Risk Factors Contributing to Development of Venous Thromboembolism for Total Knee Replacements Patients Prophylaxed With Rivaroxaban: A Retrospective Case-Control Study by Mian, Owais, Matino, Davide, Roberts, Robin, McDonald, Ellen, Chan, Anthony K. C., Chan, Howard H. W.

“…Rivaroxaban after total knee arthroplasty (TKA) is used to prevent postoperative venous thromboembolism (VTE); however, despite thromboprophylaxis, some…”
Get full text

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association by Patel, Onisha, Griffin, Michael D. W., Panjikar, Santosh, Dai, Weiwen, Ma, Xiuquan, Chan, Howard, Zheng, Celine, Kropp, Ashleigh, Murphy, James M., Daly, Roger J., Lucet, Isabelle S.

“…The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling…”
Get full text

Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants by Nguyen, Elizabeth V., Centenera, Margaret M., Moldovan, Max, Das, Rajdeep, Irani, Swati, Vincent, Andrew D., Chan, Howard, Horvath, Lisa G., Lynn, David J., Daly, Roger J., Butler, Lisa M.

“…Inhibition of the heat shock protein 90 (Hsp90) chaperone is a promising therapeutic strategy to target expression of the androgen receptor (AR) and other…”
Get full text

The effect of financial constraints, investment policy, product market competition and corporate governance on the value of cash holdings by Chan, Howard W. H., Lu, Yufei, Zhang, Hong F.

“…This study empirically investigates the value shareholders place on excess cash holdings and how shareholders’ valuation of cash holdings is associated with…”
Get full text

In-vitro assessment of the effect of dabigatran on thrombosis of adult and neonatal plasma: comparisons using thromboelastography and microscopic visualization of fibrin clot structure by Nossair, Fadi F, Chan, Howard H.W, Gantioqui, Jorell, Atkinson, Helen M, Berry, Leslie R, Chan, Anthony K.C

“…Thromboelastography (TEG) is a global assay used for evaluating features of clot formation in vitro. Dabigatran is a reversible direct inhibitor of thrombin…”
Get full text

Momentum in Australian style portfolios: risk or inefficiency? by Chan, Howard, Docherty, Paul

“…Momentum strategies have been reported to be successful across a range of different markets and asset classes. Three possible explanations for momentum have…”
Get full text

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation by Ma, Xiuquan, Zhang, Luxi, Song, Jiangning, Nguyen, Elizabeth, Lee, Rachel S., Rodgers, Samuel J., Li, Fuyi, Huang, Cheng, Schittenhelm, Ralf B., Chan, Howard, Chheang, Chanly, Wu, Jianmin, Brown, Kristin K., Mitchell, Christina A., Simpson, Kaylene J., Daly, Roger J.

“…Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimates the complexity of…”
Get full text

Do brokers' recommendation changes generate brokerage? Evidence from a central limit order market by Brown, Rob, Chan, Howard W. H., Faff, Robert W., Ho, Yew Kee, Smith, Tom

“…We examine the short‐term response to recommendation changes on the Australian Securities Exchange, a central limit order market. In both central limit order…”
Get full text

INTEGRATE II: randomised phase III controlled trials of regorafenib containing regimens versus standard of care in refractory Advanced Gastro-Oesophageal Cancer (AGOC): a study by the Australasian Gastro-Intestinal Trials Group (AGITG) by Lam, Lyn Ley, Pavlakis, Nick, Shitara, Kohei, Sjoquist, Katrin M, Martin, Andrew J, Yip, Sonia, Kang, Yoon-Koo, Bang, Yung-Jue, Chen, Li-Tzong, Moehler, Markus, Bekaii-Saab, Tanios, Alcindor, Thierry, O'Callaghan, Christopher J, Tebbutt, Niall C, Hague, Wendy, Chan, Howard, Rha, Sun Young, Lee, Keun-Wook, Gebski, Val, Jaworski, Anthony, Zalcberg, John, Price, Timothy, Simes, John, Goldstein, David

“…Advanced gastro-oesophageal cancer (AGOC) carries a poor prognosis. No standard of care treatment options are available after first and second-line therapies…”
Get full text

The AGITG GAP Study: A Phase II Study of Perioperative Gemcitabine and Nab-Paclitaxel for Resectable Pancreas Cancer by Barbour, Andrew P., Samra, Jaswinder S., Haghighi, Koroush S., Donoghoe, Mark W., Burge, Matthew, Harris, Marion T., Chua, Yu Jo, Mitchell, Jenna, O’Rourke, Nick, Chan, Howard, Gebski, Val J., Gananadha, Sivakumar, Croagh, Daniel G., Kench, James G., Goldstein, David

“…Background While combination therapy with nab -paclitaxel/gemcitabine ( nab -gem) is effective in pancreatic ductal adenocarcinoma (PDAC), its efficacy as…”
Get full text

VA-ECMO With Pericardiocentesis and Autologous Blood Transfusion - Stabilisation Strategy in Acute Cardiac Free Wall Rupture by Ho, Cheuk Bong, Wong, Ivan, Chun Chan, Alan Ka, Yan Chan, Howard Ho, Chan, Kam Tim, Kang-Yin Lee, Michael

“…A 68-year old lady present with left ventricular free wall rupture and cardiac arrest post-myocardial infarction. This article illustrates a strategy combining…”
Get full text

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway by CROUCHER, David R, HOCHGRÄFE, Falko, SHEARER, Robert, GALLEGO-ORTEGA, David, SAUNDERS, Darren N, SWARBRICK, Alexander, DALY, Roger J, LUXI ZHANG, LING LIU, LYONS, Ruth J, RICKWOOD, Danny, TACTACAN, Carole M, BROWNE, Brigid C, ALI, Naveid, CHAN, Howard

“…Basal breast cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pathogenicity of this disease. In this study, we…”
Get full text

Selective D-Dimer Testing for Diagnosis of a First Suspected Episode of Deep Venous Thrombosis: A Randomized Trial by LINKINS, Lori-Ann, BATES, Shannon M, LEE, Agnes Y. Y, O'DONNELL, Martin J, CROWTHER, Mark A, CHAN, Howard H, LIM, Wendy, SCHULMAN, Sam, GINSBERG, Jeffrey S, KEARON, Clive, LANG, Eddy, KAHN, Susan R, DOUKETIS, James D, JULIAN, Jim, PARPIA, Sameer, GROSS, Peter, WEITZ, Jeffrey I, SPENCER, Frederick A

“…D-Dimer testing is sensitive but not specific for diagnosing deep venous thrombosis (DVT). Changing the use of testing and the threshold level for a positive…”
Get full text

Predictive factors for prolonged hospitalisation in acute pyelonephritis patients admitted to the emergency medicine ward by Chan, Howard Tat Chun, Leung, Ling Yan, Law, Alex Kwok Keung, Cheng, Chi Hung, Graham, Colin A

“…Background: Acute pyelonephritis is a bacterial infection of the upper urinary tract. Patients can be admitted to a variety of wards for treatment. However, at…”
Get full text

Carotid artery dissections: Thrombosis of the false lumen by Stevic, Ivan, Chan, Howard H.W, Chan, Anthony K.C

“…Abstract Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the…”
Get full text

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes by Fleuren, Emmy D G, Vlenterie, Myrella, van der Graaf, Winette T A, Hillebrandt-Roeffen, Melissa H S, Blackburn, James, Ma, Xiuquan, Chan, Howard, Magias, Mandy C, van Erp, Anke, van Houdt, Laurens, Cebeci, Sabri A S, van de Ven, Amy, Flucke, Uta E, Heyer, Erin E, Thomas, David M, Lord, Christopher J, Marini, Kieren D, Vaghjiani, Vijesh, Mercer, Tim R, Cain, Jason E, Wu, Jianmin, Versleijen-Jonkers, Yvonne M H, Daly, Roger J

“…Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor…”
Get full text