Search Results - "CHAN, Homan"

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED by Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En

“…H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was…”
Get full text

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation by Qi, Wei, Chan, HoMan, Tenga, Lin, Li, Ling, Chuai, Shannon, Zhang, Ruipeng, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Gu, Justin, Ardayfio, Ophelia, Zhang, Ji-Hu, Yan, Xiaoxia, Fang, Jialuo, Mi, Yuan, Zhang, Man, Zhou, Tao, Feng, Grace, Chen, Zijun, Li, Guobin, Yang, Teddy, Zhao, Kehao, Liu, Xianghui, Yu, Zhengtian, Lu, Chris X., Atadja, Peter, Li, En

“…Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by…”
Get full text

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks by Schmitges, Frank W., Prusty, Archana B., Faty, Mahamadou, Stützer, Alexandra, Lingaraju, Gondichatnahalli M., Aiwazian, Jonathan, Sack, Ragna, Hess, Daniel, Li, Ling, Zhou, Shaolian, Bunker, Richard D., Wirth, Urs, Bouwmeester, Tewis, Bauer, Andreas, Ly-Hartig, Nga, Zhao, Kehao, Chan, Homan, Gu, Justin, Gut, Heinz, Fischle, Wolfgang, Müller, Jürg, Thomä, Nicolas H.

“…The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2…”
Get full text

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma by ZHENG HUANG, HAIPING WU, GU, Justin, MAN ZHANG, YANG, Teddy, KEHAO ZHAO, YANYAN YU, JINGQUAN DAI, WEI YI, SHAOLIAN ZHOU, QIAN LI, JING WU, SHANNON CHUAI, JUN LIU, XU WU, CHAN, Homan, LU, Chris, ATADJA, Peter, EN LI, YAN WANG, MIN HU, FIONA XU, FENG YAN, ENGLUND, Nathan, ZHAOFU WANG, HAILONG ZHANG, MING FANG, YOUZHEN WANG

“…Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20%…”
Get full text

6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors by Sarver, Patrick, Acker, Michael, Bagdanoff, Jeffrey T, Chen, Zhouliang, Chen, Ying-Nan, Chan, Homan, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hao, Huaixiang, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Gang, Liu, Shumei, Liu, Chen, McNeill, Eric, Mohseni, Morvarid, Sendzik, Martin, Stams, Travis, Spence, Stan, Tamez, Victoriano, Tichkule, Ritesh, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, Yu, Bing, LaMarche, Matthew J

“…Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell…”
Get full text

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors by Bagdanoff, Jeffrey T, Chen, Zhouliang, Acker, Michael, Chen, Ying-Nan, Chan, Homan, Dore, Michael, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Shumei, Mohseni, Movarid, Ntaganda, Rukundo, Sarver, Patrick, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, LaMarche, Matthew J

“…SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and…”
Get full text

A chemical genetics approach for the functional assessment of novel cancer genes by Zhou, Qianhe, Derti, Adnan, Ruddy, David, Rakiec, Daniel, Kao, Iris, Lira, Michelle, Gibaja, Veronica, Chan, HoMan, Yang, Yi, Min, Junxia, Schlabach, Michael R, Stegmeier, Frank

“…Assessing the functional significance of novel putative oncogenes remains a significant challenge given the limitations of current loss-of-function tools…”
Get full text

Abstract LB-005: Allosteric SHP2 phosphatase inhibition: Multiple mechanisms and chemotypes by LaMarche, Matthew J., Bagdanoff, Jeff, Acker, Mike, Chen, Ying-Nan, Chan, Homan, Dore, Michael, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, Bonte, Laura La, Liu, Shumei, Mohseni, Movarid, Ntaganda, Rukundo, Sarver, Patrick, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Chris, Wang, Hongyun, Wang, Ping, Williams, Sarah, Chen, Zhouliang, Hao, Huaixiang, Liu, Gang, Liu, Chen, McNeill, Eric, Yu, Bing

“…Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator due to its role in the programmed cell death…”
Get full text

Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors by Bagdanoff, Jeffrey T, Chen, Zhouliang, Acker, Michael, Chen, Ying-Nan, Chan, Homan, Dore, Michael, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hentemann, Murphy, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Shumei, Mohseni, Movarid, Ntaganda, Rukundo, Sarver, Patrick, Shultz, Michael D, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, LaMarche, Matthew J

Get full text

Correction to 6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors by Sarver, Patrick, Acker, Michael, Bagdanoff, Jeffrey T, Chen, Zhouliang, Chen, Ying-Nan, Chan, Homan, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hao, Huaixiang, Hentemann, Murphy, Jouk, Andriana, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Gang, Liu, Shumei, Liu, Chen, McNeill, Eric, Mohseni, Morvarid, Shultz, Michael D, Sendzik, Martin, Stams, Travis, Spence, Stan, Tamez, Victoriano, Tichkule, Ritesh, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, Yu, Bing, LaMarche, Matthew J

Get full text

Abstract LB-288: An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED by Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Qi, Fei, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Lingel, Andreas, Li, Guobin, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En

“…Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED and SUZ12 and plays pivotal roles in transcriptional regulation through its…”
Get full text

Abstract PR01: Global chromatin profiling identifies NSD2 mutations in pediatric acute lymphoblastic leukemia by Jaffe, Jacob, Wang, Yan, Chan, HoMan, Zhang, Jinghui, Huether, Roberts, Kryukov, Gregory, Taylor, Jordan, Hu, Min, Englund, Nathan, Yan, Feng, Wang, Zhaofu, Wei, Lei, Ma, Jing, Easton, John, Sellers, William R., Keen, Nicholas, Liu, Jun, Mullighan, Charles, Carr, Steven, Downing, James, Garraway, Levi, Stegmeier, Frank

“…Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of recurrent somatic mutations in chromatin modifying enzymes implies a…”
Get full text