Search Results - "CHAN, DAVID"

Mitochondrial Dynamics and Its Involvement in Disease by Chan, David C

“…The dynamic properties of mitochondria-including their fusion, fission, and degradation-are critical for their optimal function in energy generation. The…”
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Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health by Chan, David C

“…Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and…”
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Metabolic regulation of mitochondrial dynamics by Mishra, Prashant, Chan, David C

“…Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from…”
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Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells by Chen, Hsiuchen, Chan, David C.

“…Cancer and stem cells appear to share a common metabolic profile that is characterized by high utilization of glucose through aerobic glycolysis. In the…”
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Mitochondrial dynamics and inheritance during cell division, development and disease by Mishra, Prashant, Chan, David C.

“…Key Points Mitochondria are organelles with key roles in cellular metabolism. They have unique cellular dynamics to ensure their proper distribution to…”
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Mitochondrial DNA: Impacting Central and Peripheral Nervous Systems by Carelli, Valerio, Chan, David C.

“…Because of their high-energy metabolism, neurons are strictly dependent on mitochondria, which generate cellular ATP through oxidative phosphorylation. The…”
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Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation by Mishra, Prashant, Carelli, Valerio, Manfredi, Giovanni, Chan, David C.

“…Mitochondrial fusion is essential for maintenance of mitochondrial function. The mitofusin GTPases control mitochondrial outer membrane fusion, whereas the…”
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Mitochondria: Dynamic Organelles in Disease, Aging, and Development by Chan, David C.

“…Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling,…”
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Mitochondrial dynamics during spermatogenesis by Varuzhanyan, Grigor, Chan, David C

“…Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially…”
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The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1 by Liu, Raymond, Chan, David C

“…Dynamin-related protein 1 (Drp1) is the GTP-hydrolyzing mechanoenzyme that catalyzes mitochondrial fission in the cell. Residing in the cytosol as dimers and…”
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Mitochondrial fusion and fission in mammals by Chan, David C

“…Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission…”
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Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization by Mishra, Prashant, Varuzhanyan, Grigor, Pham, Anh H., Chan, David C.

“…Skeletal muscle fibers differentiate into specific fiber types with distinct metabolic properties determined by their reliance on oxidative phosphorylation…”
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THE EFFICIENCY OF SLACKING OFF: EVIDENCE FROM THE EMERGENCY DEPARTMENT by Chan, David C.

“…Work schedules play an important role in utilizing labor in organizations. In this study of emergency department physicians in shift work, schedules induce two…”
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Selection with Variation in Diagnostic Skill: Evidence from Radiologists by Chan, David C, Gentzkow, Matthew, Yu, Chuan

“…Abstract Physicians, judges, teachers, and agents in many other settings differ systematically in the decisions they make when faced with similar cases…”
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Teamwork and Moral Hazard: Evidence from the Emergency Department by Chan, David C.

“…I investigate how teamwork may reduce moral hazard by joint monitoring and management. I study two organizational systems differing in the extent to which…”
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Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases by Chen, Hsiuchen, Chan, David C.

“…Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on…”
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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission by Losón, Oliver C, Song, Zhiyin, Chen, Hsiuchen, Chan, David C

“…Several mitochondrial outer membrane proteins-mitochondrial fission protein 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics proteins of 49…”
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Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1 by Rojansky, Rebecca, Cha, Moon-Yong, Chan, David C

“…A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal…”
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Functions and dysfunctions of mitochondrial dynamics by Chan, David C, Detmer, Scott A

“…Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are…”
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Current understanding of fatty acid biosynthesis and the acyl carrier protein by Chan, David I, Vogel, Hans J

“…FA (fatty acid) synthesis represents a central, conserved process by which acyl chains are produced for utilization in a number of end-products such as…”
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