Search Results - "CHAMULEAU, Robert A. F. M"

A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines by Adam, Aziza A A, van der Mark, Vincent A, Donkers, Joanne M, Wildenberg, Manon E, Oude Elferink, Ronald P J, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines…”
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End-stage liver failure: filling the treatment gap at the intensive care unit by Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje

“…End-stage liver failure is a condition of collapsing liver function with mortality rates up to 80. Liver transplantation is the only lifesaving therapy. There…”
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Prediction of poor outcome in patients with acute liver failure-systematic review of prediction models by Wlodzimirow, Kama A, Eslami, Saeid, Chamuleau, Robert A F M, Nieuwoudt, Martin, Abu-Hanna, Ameen

“…Acute liver failure is a rare disease with high mortality and liver transplantation is the only life saving therapy. Accurate prognosis of ALF is crucial for…”
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Liver progenitor cell line HepaRG differentiated in a bioartificial liver effectively supplies liver support to rats with acute liver failure by Nibourg, Geert A A, Chamuleau, Robert A F M, van der Hoeven, Tessa V, Maas, Martinus A W, Ruiter, An F C, Lamers, Wouter H, Oude Elferink, Ronald P J, van Gulik, Thomas M, Hoekstra, Ruurdtje

“…A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic…”
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Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR by Adam, Aziza A. A., Jongejan, Aldo, Moerland, Perry D., van der Mark, Vincent A., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje

“…Human liver cell line HepaRG is a well-known source of human hepatocyte-like cells which, however, displays limited biotransformation and a tendency to…”
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Which are the right cells to be used in a bioartificial liver? by CHAMULEAU, Robert A. F. M, DEURHOLT, Tanja, HOEKSTRA, Ruurdtje

“…Anno 2004 freshly isolated or cryopreserved porcine or human hepatocytes have been most frequently used as bio-component in clinically applied bioartificial…”
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Three-dimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver by Mareels, Guy, Poyck, Paul P C, Eloot, Sunny, Chamuleau, Robert A F M, Verdonck, Pascal R

“…A numerical model to investigate fluid flow and oxygen (O(2)) transport and consumption in the AMC-Bioartificial Liver (AMC-BAL) was developed and applied to…”
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Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats by WLODZIMIROW, K. A, ABU-HANNA, A, SCHULTZ, M. J, MAAS, M. A. W, BOS, L. D. J, STERK, P. J, KNOBEL, H. H, SOERS, R. J. T, CHAMULEAU, Robert A. F. M

“…The aim of this study was to assess the classification accuracy of an e-Nose in detecting acute liver failure (ALF) in rats. Exhaled breath from 14 rats was…”
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Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines by van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje

“…The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation…”
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Clinical application of Bioartificial liver support systems by VAN DE KERKHOVE, Maarten Paul, HOEKSTRA, Ruurdtje, CHAMULEAU, Robert A. F. M, VAN GULIK, Thomas M

“…To review the present status of bioartificial liver (BAL) devices and their obtained clinical results. Acute liver failure (ALF) is a disease with a high…”
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Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver by Poyck, Paul P.C, van Wijk, Albert C.W.A, van der Hoeven, Tessa V, de Waart, Dirk R, Chamuleau, Robert A.F.M, van Gulik, Thomas M, Oude Elferink, Ronald P.J, Hoekstra, Ruurdtje

“…Background/Aims Clinical use of bioartificial livers (BAL) relies heavily on the development of human liver cell lines. The aim of this study was to assess the…”
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Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia by Schaap, Frank G., Nierman, Melchior C., Berbée, Jimmy F.P., Hattori, Hiroaki, Talmud, Philippa J., Vaessen, Stefan F.C., Rensen, Patrick C.N., Chamuleau, Robert A.F.M., Kuivenhoven, Jan Albert, Groen, Albert K.

“…The relevance of apolipoprotein A-V (apoA-V) for human lipid homeostasis is underscored by genetic association studies and the identification of…”
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A systematic review on prognostic indicators of acute on chronic liver failure and their predictive value for mortality by Wlodzimirow, Kama A., Eslami, Saeid, Abu-Hanna, Ameen, Nieuwoudt, Martin, Chamuleau, Robert A. F. M.

“…Background An early and proper diagnosis of acute on chronic liver failure (ACLF), together with the identification of indicators associated with disease…”
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A comparison of RIFLE with and without urine output criteria for acute kidney injury in critically ill patients by Wlodzimirow, Kama A, Abu-Hanna, Ameen, Slabbekoorn, Mathilde, Chamuleau, Robert A F M, Schultz, Marcus J, Bouman, Catherine S C

“…The Risk, Injury, Failure, Loss, and End-Stage Renal Disease (RIFLE) is a consensus-based classification system for diagnosing acute kidney insufficiency…”
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Bridging a patient with acute liver failure to liver transplantation by the AMC-bioartificial liver by van de Kerkhove, Maarten-Paul, Di Florio, Ernesto, Scuderi, Vincenzo, Mancini, Antonio, Belli, Antonello, Bracco, Adele, Scala, Daniela, Scala, Simona, Zeuli, Laura, Di Nicuolo, Giuseppe, Amoroso, Pietro, Calise, Fulvio, Chamuleau, Robert A F M

“…Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the…”
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Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells by van der Mark, Vincent A., Adam, Aziza A.A., Chang, Jung-Chin, Oude Elferink, Ronald P., Chamuleau, Robert A.F.M., Hoekstra, Ruurdtje

“…The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. However, mitochondrial energy metabolism is…”
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Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells by van der Mark, Vincent A, Rudi de Waart, D, Shevchenko, Valery, Elferink, Ronald P J Oude, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG; however, DMSO also…”
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In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions by Deurholt, Tanja, ten Bloemendaal, Lysbeth, Chhatta, Aniska A, van Wijk, Albert C W A, Weijer, Kees, Seppen, Jurgen, Elferink, Ronald P J Oude, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Mature human hepatocytes are not suitable for large-scale in vitro applications that rely on hepatocyte function, due to their limited availability and…”
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Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines by van Wenum, Martien, Adam, Aziza A A, Hakvoort, Theodorus B M, Hendriks, Erik J, Shevchenko, Valery, van Gulik, Thomas M, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell…”
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The HepaRG cell line is suitable for bioartificial liver application by Hoekstra, Ruurdtje, Nibourg, Geert A.A., van der Hoeven, Tessa V., Ackermans, Mariëtte T., Hakvoort, Theodorus B.M., van Gulik, Thomas M., Lamers, Wouter H., Elferink, Ronald P. Oude, Chamuleau, Robert A.F.M.

“…[Display omitted] • Cell line HepaRG was tested in monolayer for its potential in bioartificial livers. • Metabolic and synthetic functionality functions were…”
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