Search Results - "CHAMBON, PIERRE"

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs by Mukherji, Atish, Kobiita, Ahmad, Ye, Tao, Chambon, Pierre

“…Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between…”
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The Nuclear Receptor Superfamily: A Personal Retrospect on the First Two Decades by Chambon, Pierre

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Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours by Mukherji, Atish, Kobiita, Ahmad, Chambon, Pierre

“…The molecular mechanisms underlying the events through which alterations in diurnal activities impinge on peripheral circadian clocks (PCCs), and reciprocally…”
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Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex by Hua, Guoqiang, Ganti, Krishna Priya, Chambon, Pierre

“…Upon binding of a glucocorticoid (GC), the GC receptor (GR) can exert one of three transcriptional regulatory functions. We recently reported that SUMOylation…”
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GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression by Hua, Guoqiang, Paulen, Laetitia, Chambon, Pierre

“…Unique among the nuclear receptor superfamily, the glucocorticoid (GC) receptor (GR) can exert three distinct transcriptional regulatory functions on binding…”
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Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications by Arnal, Jean-Francois, Lenfant, Françoise, Metivier, Raphaël, Flouriot, Gilles, Henrion, Daniel, Adlanmerini, Marine, Fontaine, Coralie, Gourdy, Pierre, Chambon, Pierre, Katzenellenbogen, Benita, Katzenellenbogen, John

“…Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous…”
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Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome by Mukherji, Atish, Kobiita, Ahmad, Damara, Manohar, Misra, Nisha, Meziane, Hamid, Champy, Marie-France, Chambon, Pierre

“…The light-entrained master central circadian clock (CC) located in the suprachiasmatic nucleus (SCN) not only controls the diurnal alternance of the active…”
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Jarid2 and PRC2, partners in regulating gene expression by Li, Gang, Margueron, Raphael, Ku, Manching, Chambon, Pierre, Bernstein, Bradley E, Reinberg, Danny

“…The Polycomb group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the…”
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Automated deidentification of radiology reports combining transformer and "hide in plain sight" rule-based methods by Chambon, Pierre J, Wu, Christopher, Steinkamp, Jackson M, Adleberg, Jason, Cook, Tessa S, Langlotz, Curtis P

“…To develop an automated deidentification pipeline for radiology reports that detect protected health information (PHI) entities and replaces them with…”
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Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance by LIN ZHU, BROWN, William C, QING CAI, KRUST, Andrée, CHAMBON, Pierre, MCGUINNESS, Owen P, STAFFORD, John M

“…Pathway-selective insulin resistance where insulin fails to suppress hepatic glucose production but promotes liver fat storage may underlie glucose and lipid…”
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Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice by MacLean, Glenn, Li, Hui, Metzger, Daniel, Chambon, Pierre, Petkovich, Martin

“…Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes…”
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Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant by Antal, Maria Cristina, Krust, Andrée, Chambon, Pierre, Mark, Manuel

“…Estrogen signaling is mediated by estrogen receptors α (ERα) and β (ERβ). Although a consensus has now been reached concerning many physiological functions of…”
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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors by McCurley, Amy, Pires, Paulo W, Bender, Shawn B, Aronovitz, Mark, Zhao, Michelle J, Metzger, Daniel, Chambon, Pierre, Hill, Michael A, Dorrance, Anne M, Mendelsohn, Michael E, Jaffe, Iris Z

“…The mineralocorticoid receptor, targeted by drugs commonly used to treat hypertension, is generally thought to contribute to hypertension by altering kidney…”
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Topical Vitamin D3 and Low-Calcemic Analogs Induce Thymic Stromal Lymphopoietin in Mouse Keratinocytes and Trigger an Atopic Dermatitis by Li, Mei, Hener, Pierre, Zhang, Zhikun, Kato, Shigeaki, Metzger, Daniel, Chambon, Pierre

“…We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyteselective ablation of retinoid X…”
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Function of retinoid nuclear receptors : Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis by MARK, Manuel, GHYSELINCK, Norbert B, CHAMBON, Pierre

“…Retinoic acid (RA) is involved in vertebrate morphogenesis, growth, cellular differentiation, and tissue homeostasis. The use of in vitro systems initially led…”
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Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions by Adlanmerini, Marine, Solinhac, Romain, Abot, Anne, Fabre, Aurélie, Raymond-Letron, Isabelle, Guihot, Anne-Laure, Boudou, Frédéric, Sautier, Lucile, Vessières, Emilie, Kim, Sung Hoon, Lière, Philippe, Fontaine, Coralie, Krust, Andrée, Chambon, Pierre, Katzenellenbogen, John A, Gourdy, Pierre, Shaul, Philip W, Henrion, Daniel, Arnal, Jean-François, Lenfant, Françoise

“…Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). A fraction of ERα is…”
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Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis by Xie, Ting, Liang, Jiurong, Liu, Ningshan, Huan, Caijuan, Zhang, Yanli, Liu, Weijia, Kumar, Maya, Xiao, Rui, D'Armiento, Jeanine, Metzger, Daniel, Chambon, Pierre, Papaioannou, Virginia E, Stripp, Barry R, Jiang, Dianhua, Noble, Paul W

“…Progressive tissue fibrosis is a major cause of the morbidity and mortality associated with repeated epithelial injuries and accumulation of myofibroblasts…”
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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis by Raverdeau, Mathilde, Gely-Pernot, Aurore, Féret, Betty, Dennefeld, Christine, Benoit, Gérard, Davidson, Irwin, Chambon, Pierre, Mark, Manuel, Ghyselinck, Norbert B

“…Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differentiation and meiotic entry of…”
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Retinoid X receptor gamma signaling accelerates CNS remyelination by ffrench-Constant, Charles, Franklin, Robin J M, Huang, Jeffrey K, Jarjour, Andrew A, Oumesmar, Brahim Nait, Kerninon, Christophe, Williams, Anna, Krezel, Wojciech, Kagechika, Hiroyuki, Bauer, Julien, Zhao, Chao, Evercooren, Anne Baron-Van, Chambon, Pierre

“…The authors report a transcriptional profile of the discrete stages of spontaneous remyelination following toxin-induced focal demyelination in rats. They find…”
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Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice by Oakley, Robert H, Cruz-Topete, Diana, He, Bo, Foley, Julie F, Myers, Page H, Xu, Xiaojiang, Gomez-Sanchez, Celso E, Chambon, Pierre, Willis, Monte S, Cidlowski, John A

“…Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates in patients with cardiometabolic disease. Glucocorticoids are…”
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