Search Results - "CHAMBERLIN, L"

Kölliker–Fuse GABAergic and glutamatergic neurons project to distinct targets by Geerling, Joel C., Yokota, Shigefumi, Rukhadze, Irma, Roe, Dan, Chamberlin, Nancy L.

“…The Kölliker‐Fuse nucleus (KF) is known primarily for its respiratory function as the “pneumotaxic center” or “pontine respiratory group.” Considered part of…”
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Sleep and Anesthesia: The Shared Circuit Hypothesis Has Been Put to Bed by Eikermann, Matthias, Akeju, Oluwaseun, Chamberlin, Nancy L.

“…Acute activation of genetically defined sleep-promoting neurons in the preoptic hypothalamus does not facilitate anesthesia. This finding supports the notion…”
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Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal by Kaur, Satvinder, Pedersen, Nigel P, Yokota, Shigefumi, Hur, Elizabeth E, Fuller, Patrick M, Lazarus, Michael, Chamberlin, Nancy L, Saper, Clifford B

“…The mechanisms of arousal from apneas during sleep in patients suffering from obstructive sleep apnea are not well understood. However, we know that…”
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Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice by Yokota, Shigefumi, Kaur, Satvinder, VanderHorst, Veronique G., Saper, Clifford B., Chamberlin, Nancy L.

“…ABSTRACT In patients with obstructive sleep apnea, airway obstruction during sleep produces hypercapnia, which in turn activates respiratory muscles that pump…”
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Sleep disturbance induces neuroinflammation and impairment of learning and memory by Zhu, Biao, Dong, Yuanlin, Xu, Zhipeng, Gompf, Heinrich S, Ward, Sarah A.P, Xue, Zhanggang, Miao, Changhong, Zhang, Yiying, Chamberlin, Nancy L, Xie, Zhongcong

“…Abstract Hospitalized patients can develop cognitive function decline, the mechanisms of which remain largely to be determined. Sleep disturbance often occurs…”
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Ketamine Activates Breathing and Abolishes the Coupling between Loss of Consciousness and Upper Airway Dilator Muscle Dysfunction by EIKERMANN, Matthias, GROSSE-SUNDRUP, Martina, ZAREMBA, Sebastian, HENRY, Mark E, BITTNER, Edward A, HOFFMANN, Ulrike, CHAMBERLIN, Nancy L

“…Procedural sedation is frequently performed in spontaneously breathing patients, but hypnotics and opioids decrease respiratory drive and place the upper…”
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Physiological mechanisms of upper airway hypotonia during REM sleep by McSharry, David G, Saboisky, Julian P, Deyoung, Pam, Jordan, Amy S, Trinder, John, Smales, Erik, Hess, Lauren, Chamberlin, Nancy L, Malhotra, Atul

“…Rapid eye movement (REM)-induced hypotonia of the major upper airway dilating muscle (genioglossus) potentially contributes to the worsening of obstructive…”
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Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial by Chamberlin, Morgan L, Wilson, Stephanie M G, Gaston, Marcy E, Kuo, Wan-Yuan, Miles, Mary P

“…Lentils have potential to improve metabolic health but there are limited randomized clinical trials evaluating their comprehensive impact on metabolism. The…”
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The influence of aging on pharyngeal collapsibility during sleep by Eikermann, Matthias, Jordan, Amy S, Chamberlin, Nancy L, Gautam, Shiva, Wellman, Andrew, Lo, Yu-Lun, White, David P, Malhotra, Atul

“…Aging increases vulnerability to obstructive sleep apnea (OSA), but the underlying mechanisms remain unclear. Recent data in awake healthy volunteers show a…”
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Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization by Negro, Andrea, Seidel, Jessica L., Houben, Thijs, Yu, Esther S., Rosen, Ike, Arreguin, Andrea J., Yalcin, Nilufer, Shorser-Gentile, Lea, Pearlman, Lea, Sadhegian, Homa, Vetrivelan, Ramalingam, Chamberlin, Nancy L., Ayata, Cenk, Martelletti, Paolo, Moskowitz, Michael A., Eikermann-Haerter, Katharina

“…Background Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is…”
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Anatomical Location of the Mesencephalic Locomotor Region and Its Possible Role in Locomotion, Posture, Cataplexy, and Parkinsonism by Sherman, David, Fuller, Patrick M, Marcus, Jacob, Yu, Jun, Zhang, Ping, Chamberlin, Nancy L, Saper, Clifford B, Lu, Jun

“…The mesencephalic (or midbrain) locomotor region (MLR) was first described in 1966 by Shik and colleagues, who demonstrated that electrical stimulation of this…”
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GENE TARGET: A framework for evaluating Mendelian neurodevelopmental disorders for gene therapy by Chopra, Maya, Modi, Meera E., Dies, Kira A., Chamberlin, Nancy L., Buttermore, Elizabeth D., Brewster, Stephanie Jo, Prock, Lisa, Sahin, Mustafa

“…Interest in gene-based therapies for neurodevelopmental disorders is increasing exponentially, driven by the rise in recognition of underlying genetic…”
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Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing by Chamberlin, Nancy L.

“…Although the medulla oblongata contains the epicenter for respiratory rhythm generation, many other parts of the neuraxis play significant substratal roles in…”
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Polyphenol-Rich Aronia melanocarpa Fruit Beneficially Impact Cholesterol, Glucose, and Serum and Gut Metabolites: A Randomized Clinical Trial by Chamberlin, Morgan L, Peach, Jesse T, Wilson, Stephanie M G, Miller, Zachary T, Bothner, Brian, Walk, Seth T, Yeoman, Carl J, Miles, Mary P

“…Polyphenol-rich Aronia fruits have great potential as a functional food with anti-inflammatory, hypolipidemic, and hypoglycemic biologic activities. However,…”
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Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing by Eikermann, M., Zaremba, S., Malhotra, A., Jordan, A.S., Rosow, C., Chamberlin, N.L.

“…Cholinesterase inhibitor-based reversal agents, given in the absence of neuromuscular block, evoke a partial upper airway obstruction by decreasing skeletal…”
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Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function by EIKERMANN, Matthias, FASSBENDER, Philipp, MALHOTRA, Atul, TAKAHASHI, Masaya, KUBO, Shigeto, JORDAN, Amy S, GAUTAM, Shiva, WHITE, David P, CHAMBERLIN, Nancy L

“…It is standard practice to administer a cholinesterase inhibitor (e.g., neostigmine) at the end of a surgical case to reverse suspected effects of…”
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Genioglossus premotoneurons and the negative pressure reflex in rats by Chamberlin, Nancy L., Eikermann, Matthias, Fassbender, Philipp, White, David P., Malhotra, Atul

“…Reflex increases in genioglossus (GG) muscle activity in response to negative pharyngeal pressure are important for maintenance of upper airway patency in…”
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Maternal feeding practices and beliefs and their relationships to overweight in early childhood by BAUGHCUM, Amy E, POWERS, Scott W, JOHNSON, Suzanne Bennett, CHAMBERLIN, Leigh A, DEEKS, Cindy M, JAIN, Anjali, WHITAKER, Robert C

“…To better explore possible factors that may lead to childhood obesity, we developed and analyzed two new instruments that assess maternal feeding practices and…”
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A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2 by Diaz-Gil, Daniel, Haerter, Friederike, Falcinelli, Shane, Ganapati, Shweta, Hettiarachchi, Gaya K, Simons, Jeroen C P, Zhang, Ben, Grabitz, Stephanie D, Moreno Duarte, Ingrid, Cotten, Joseph F, Eikermann-Haerter, Katharina, Deng, Hao, Chamberlin, Nancy L, Isaacs, Lyle, Briken, Volker, Eikermann, Matthias

“…BACKGROUND:Calabadion 2 is a new drug-encapsulating agent. In this study, the authors aim to assess its utility as an agent to reverse general anesthesia with…”
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Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro by Arrigoni, E., Chamberlin, N.L., Saper, C.B., McCarley, R.W.

“…Adenosine has been proposed as a homeostatic “sleep factor” that promotes the transition from waking to sleep by affecting several sleep–wake regulatory…”
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