Search Results - "CHAMBERLAIN, Jason"

A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study by Botson, John K, Tesser, John R P, Bennett, Ralph, Kenney, Howard M, Peloso, Paul M, Obermeyer, Katie, Song, Yang, LaMoreaux, Brian, Zhao, Lin, Xin, Yan, Chamberlain, Jason, Ramanathan, Srini, Weinblatt, Michael E, Peterson, Jeff

“…Publications suggest immunomodulation co-therapy improves responder rates in uncontrolled/refractory gout patients undergoing pegloticase treatment. The MIRROR…”
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Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B by Daffis, Stephane, Balsitis, Scott, Chamberlain, Jason, Zheng, Jim, Santos, Rex, Rowe, William, Ramakrishnan, Dhivya, Pattabiraman, Divya, Spurlock, Sandra, Chu, Ruth, Kang, Don, Mish, Michael, Ramirez, Ricardo, Li, Li, Li, Bei, Ma, Sarina, Hung, Magdeleine, Voitenleitner, Christian, Yon, Changsuek, Suresh, Manasa, Menne, Stephan, Cote, Paul, Delaney, William E., Mackman, Richard, Fletcher, Simon P.

“…Background and Aims GS‐9688 (selgantolimod) is an oral selective small molecule agonist of toll‐like receptor 8 in clinical development for the treatment of…”
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Pharmacokinetics and Immunogenicity of Pegloticase in Patients With Kidney Transplants Receiving Pegloticase for Uncontrolled Gout: FR-PO232 by Abdellatif, Abdul A., Xin, Yan, Chamberlain, Jason, Zhao, Lin, Cherny, Katya, Marder, Brad A., Scandling, John D., Saag, Kenneth G.

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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B by Mackman, Richard L, Mish, Michael, Chin, Gregory, Perry, Jason K, Appleby, Todd, Aktoudianakis, Vangelis, Metobo, Sammy, Pyun, Peter, Niu, Congrong, Daffis, Stephane, Yu, Helen, Zheng, Jim, Villasenor, Armando G, Zablocki, Jeff, Chamberlain, Jason, Jin, Haolun, Lee, Gary, Suekawa-Pirrone, Kimberley, Santos, Rex, Delaney, William E, Fletcher, Simon P

“…Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B…”
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A Randomized, Placebo‐Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings by Botson, John K., Saag, Kenneth, Peterson, Jeff, Parikh, Naval, Ong, Stephen, La, Dan, LoCicero, Karon, Obermeyer, Katie, Xin, Yan, Chamberlain, Jason, LaMoreaux, Brian, Verma, Supra, Sainati, Stephen, Grewal, Suneet, Majjhoo, Amar, Tesser, John R. P., Weinblatt, Michael E.

“…Objective To assess efficacy, safety, pharmacokinetics, and immunogenicity of pegloticase plus methotrexate (MTX) versus pegloticase plus placebo cotreatment…”
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Pharmacokinetics and Exposure-Response Relationship of Teprotumumab, an Insulin-Like Growth Factor-1 Receptor-Blocking Antibody, in Thyroid Eye Disease by Xin, Yan, Xu, Fengyan, Gao, Yuying, Bhatt, Nivedita, Chamberlain, Jason, Sile, Saba, Hammel, Suzy, Holt, Robert J., Ramanathan, Srini

“…Background and Objective Thyroid eye disease (TED) is characterized by inflammation/expansion of orbital tissues, proptosis, and diplopia. Teprotumumab is the…”
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Pegloticase efficacy and safety in kidney transplant recipients; results of the phase IV, open-label PROTECT clinical trial by Abdellatif, Abdul, Zhao, Lin, Chamberlain, Jason, Cherny, Katya, Xin, Yan, Marder, Brad A, Scandling, John D, Saag, Kenneth

“…Kidney transplant (KT) recipients have a high prevalence and severity of gout. Pegloticase (pegylated recombinant uricase) rapidly metabolizes serum uric acid…”
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Efficient generation of human hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep by Chamberlain, Jason, Yamagami, Takashi, Colletti, Evan, Theise, Neil D., Desai, Jyoti, Frias, Ana, Pixley, John, Zanjani, Esmail D., Porada, Christopher D., Almeida‐Porada, Graça

“…Alternative methods to whole liver transplantation require a suitable cell that can be expanded to obtain sufficient numbers required for successful…”
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SAT-432 Pharmacokinetics (PK) and Exposure-Response Relationship of Teprotumumab, an Insulin-Like Growth Factor-1 Receptor (IGF-1R) Blocking Antibody, in Active Thyroid Eye Disease (TED) by Xin, Yan, Xu, Fengyan, Gao, Yuying, Bhatt, Nivedita, Chamberlain, Jason, Kovalenko, Maria, Sile, Saba, Sun, Rui, Holt, Robert, Ramanathan, Srini

“…Introduction: Teprotumumab treatment resulted in statistically and clinically meaningful improvements across multiple facets of active TED and was generally…”
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Formation of human hepatocytes by human hematopoietic stem cells in sheep by Almeida-Porada, Graça, Porada, Christopher D., Chamberlain, Jason, Torabi, Ali, Zanjani, Esmail D.

“…We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in…”
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Human mesenchymal stem cells form Purkinje fibers in fetal sheep heart by AIREY, Judith A, ALMEIDA-PORADA, Graca, COLLETTI, Evan J, PORADA, Christopher D, CHAMBERLAIN, Jason, MOVSESIAN, Matthew, SUTKO, John L, ZANJANI, Esmail D

“…We have investigated the usefulness of a model of cardiac development in a large mammal, sheep, for studies of engraftment of human stem cells in the heart…”
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Proteomic Analysis Reveals Intrinsic Differences between Phenotypically Identical Mesenchymal Stem Cells by Mazhari, Sam, Desai, Jyoti, Chamberlain, Jason, Porada, Chris, Zanjani, Esmail D., Almeida-Porada, Graca

“…We have previously reported the isolation of Stro-1+, CD45-, GlyA-human MSC from human bone marrow (BM), liver (LV), and brain (BR). Despite their similar…”
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The time course of engraftment of human mesenchymal stem cells in fetal heart demonstrates that Purkinje fiber aggregates derive from a single cell and not multi-cell homing by Colletti, Evan J., Almeida-Porada, Graça, Chamberlain, Jason, Zanjani, Esmail D., Airey, Judith A.

“…To study the early time course of engraftment of human mesenchymal stem cells in fetal sheep heart and determine the relative roles of proliferation and homing…”
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Tissue Availability of Donor Mesenchymal Stem Cells Determines the Degree of Plasticity Following Transplantation in a Non-Injury Model by Chamberlain, Jason, Porada, Christopher D., Frias, Ana, Yamagami, Takashi, Zanjani, Esmail D., Almeida-Porada, Graca

“…The ability of bone marrow-derived Hematopoietic and Mesenchymal Stem Cells (MSC) to generate hepatocytes in a large non-injury sheep model of human stem cell…”
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Isolation, characterization and in vivo differentiative potential of human mesenchymal stem cells by Chamberlain, Jason

“…Recent studies have demonstrated the tremendous differentiative potential of bone marrow (BM) mesenchymal stem cells (MSC), implicating them in repair and…”
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Isolation, characterization and in vivo differentiative potential of human mesenchymal stem cells by Chamberlain, Jason

“…Recent studies have demonstrated the tremendous differentiative potential of bone marrow (BM) mesenchymal stem cells (MSC), implicating them in repair and…”
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