Search Results - "CHAMBAZ, Jean"

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia by Moulin, Philippe, Wickham, Louise, Bruckert, Eric, Lecerf, Jean-Michel, Krempf, Michel, Varret, Mathilde, Chambaz, Jean, Allard, Delphine, Derré, Aurélie, Rabès, Jean-Pierre, Villéger, Ludovic, Junien, Claudine, Erlich, Danièle, Beucler, Isabel, Cruaud, Corinne, Benjannet, Suzanne, Farnier, Michel, Ouguerram, Khadija, Devillers, Martine, Boileau, Catherine, Luc, Gerald, Weissenbach, Jean, Abifadel, Marianne, Prat, Annick, Chanu, Bernard, Seidah, Nabil G

“…Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an increase in low-density lipoprotein…”
Get full text

The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics by Bouchoux, Julien, Beilstein, Frauke, Pauquai, Thomas, Guerrera, I. Chiara, Chateau, Danielle, Ly, Nathalie, Alqub, Malik, Klein, Christophe, Chambaz, Jean, Rousset, Monique, Lacorte, Jean-Marc, Morel, Etienne, Demignot, Sylvie

“…Background information. Intestinal absorption of alimentary lipids is a complex process ensured by enterocytes and leading to TRL [TAG (triacylglycerol)‐rich…”
Get full text

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction by Froguel, Philippe, Clément, Karine, Vaisse, Christian, Lahlou, Najiba, Cabrol, Sylvie, Pelloux, Veronique, Cassuto, Dominique, Gourmelen, Micheline, Dina, Christian, Chambaz, Jean, Lacorte, Jean-Marc, Basdevant, Arnaud, Bougnères, Pierre, Lebouc, Yves, Guy-Grand, Bernard

“…The adipocyte-specific hormone leptin, the product of the obese (ob) gene,regulates adipose-tissue mass through hypothalamic effects on satiety and energy…”
Get full text

Sensing of Dietary Lipids by Enterocytes: A New Role for SR-BI/CLA-1 by Béaslas, Olivier, Cueille, Carine, Delers, François, Chateau, Danielle, Chambaz, Jean, Rousset, Monique, Carrière, Véronique

“…Background: The intestine is responsible for absorbing dietary lipids and delivering them to the organism as triglyceride-rich lipoproteins (TRL). It is…”
Get full text

The Cellular Prion Protein PrPc Is Involved in the Proliferation of Epithelial Cells and in the Distribution of Junction-Associated Proteins by Morel, Etienne, Fouquet, Stéphane, Strup-Perrot, Carine, Thievend, Cathy Pichol, Petit, Constance, Loew, Damarys, Faussat, Anne-Marie, Yvernault, Lucile, Pinçon-Raymond, Martine, Chambaz, Jean, Rousset, Monique, Thenet, Sophie, Clair, Caroline

“…Background The physiological function of the ubiquitous cellular prion protein, PrPc, is still under debate. It was essentially studied in nervous system, but…”
Get full text

Resistance of colon cancer cells to long‐term 5‐fluorouracil exposure is correlated to the relative level of Bcl‐2 and Bcl‐XL in addition to Bax and p53 status by Violette, Sabine, Poulain, Laurent, Dussaulx, Elisabeth, Pepin, Dominique, Faussat, Anne‐Marie, Chambaz, Jean, Lacorte, Jean‐Marc, Staedel, Cathy, Lesuffleur, Thécla

“…Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5‐fluorouracil‐induced apoptosis of…”
Get full text

Bovine Prion Is Endocytosed by Human Enterocytes via the 37 kDa/67 kDa Laminin Receptor by Morel, Etienne, Andrieu, Thibault, Casagrande, Fabrice, Gauczynski, Sabine, Weiss, Stefan, Grassi, Jacques, Rousset, Monique, Dormont, Dominique, Chambaz, Jean

“…Some forms of transmissible spongiform encephalopathies result from oral infection. We have thus analyzed the early mechanisms that could account for an uptake…”
Get full text

Early Loss of E-cadherin from Cell-Cell Contacts Is Involved in the Onset of Anoikis in Enterocytes by Stéphane Fouquet, Verónica-Haydée Lugo-Martínez, Anne-Marie Faussat, Flore Renaud, Philippe Cardot, Jean Chambaz, Martine Pinçon-Raymond, Sophie Thenet

“…Anoikis, i.e. apoptosis induced by detachment from the extracellular matrix, is thought to be involved in the shedding of enterocytes at the tip of intestinal…”
Get full text

The cellular prion protein PrP(c) is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins by Morel, Etienne, Fouquet, Stéphane, Strup-Perrot, Carine, Pichol Thievend, Cathy, Thievend, Cathy Pichol, Petit, Constance, Loew, Damarys, Faussat, Anne-Marie, Yvernault, Lucile, Pinçon-Raymond, Martine, Chambaz, Jean, Rousset, Monique, Thenet, Sophie, Clair, Caroline

“…The physiological function of the ubiquitous cellular prion protein, PrP(c), is still under debate. It was essentially studied in nervous system, but poorly…”
Get full text

Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet by Hernández Vallejo, Sandra Jimena, Alqub, Malik, Luquet, Serge, Cruciani-Guglielmacci, Céline, Delerive, Philippe, Lobaccaro, Jean-Marc, Kalopissis, Athina-Despina, Chambaz, Jean, Rousset, Monique, Lacorte, Jean-Marc

“…Western diet is characterized by a hypercaloric and hyperlipidic intake, enriched in saturated fats, that is associated with the increased occurrence of…”
Get more information

Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions by Lugo-Martínez, Verónica-Haydée, Petit, Constance S, Fouquet, Stéphane, Le Beyec, Johanne, Chambaz, Jean, Pinçon-Raymond, Martine, Cardot, Philippe, Thenet, Sophie

“…Enterocytes of the intestinal epithelium are continually regenerated. They arise from precursor cells in crypts, migrate along villi, and finally die, 3-4 days…”
Get more information

Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas by Violette, Sabine, Festor, Estelle, Pandrea‐Vasile, Ivona, Mitchell, Valérie, Adida, Colette, Dussaulx, Elisabeth, Lacorte, Jean‐Marc, Chambaz, Jean, Lacasa, Michel, Lesuffleur, Thécla

“…A better understanding of the mechanisms by which colon tumor cells are able to survive exposure to drugs would be valuable for the development of new…”
Get full text

Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes by Vidal, Romain, Hernandez-Vallejo, Sandra, Pauquai, Thomas, Texier, Odile, Rousset, Monique, Chambaz, Jean, Demignot, Sylvie, Lacorte, Jean-Marc

“…Decrease of plasma lipid levels by polyphenols was linked to impairment of hepatic lipoprotein secretion. However, the intestine is the first epithelium that…”
Get full text

Lipid micelles stimulate the secretion of triglyceride-enriched apolipoprotein B48-containing lipoproteins by Caco-2 cells by Chateau, Danielle, Pauquai, Thomas, Delers, François, Rousset, Monique, Chambaz, Jean, Demignot, Sylvie

“…Intestinal triglyceride‐rich lipoproteins (TRL) are synthesized from dietary lipids. This study was designed to evaluate the effects of lipid micelles,…”
Get full text

inter-laboratory study to evaluate the effects of medium composition on the differentiation and barrier function of Caco-2 cell lines by Zucco, F, Batto, A.F, Bises, G, Chambaz, J, Chiusolo, A, Consalvo, R, Cross, H, Dal Negro, G, Angelis, I. de, Fabre, G

“…Differentiated human intestinal Caco-2 cells are frequently used in toxicology and pharmacology as in vitro models for studies on intestinal barrier functions…”
Get full text

Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes by Schreider, Cyrille, Peignon, Gregory, Thenet, Sophie, Chambaz, Jean, Pinçon-Raymond, Martine

“…Enterocyte differentiation is a dynamic process during which reinforcement of cell-cell adhesion favours migration along the crypt-to-villus axis. Functional…”
Get full text

The Cellular Prion Protein PrPc Is Expressed in Human Enterocytes in Cell-Cell Junctional Domains by Morel, Etienne, Fouquet, Stephane, Chateau, Danielle, Yvernault, Lucile, Frobert, Yveline, Pinçon-Raymond, Martine, Chambaz, Jean, Pillot, Thierry, Rousset, Monique

“…The physiological function of PrPc, the cellular isoform of prion protein, still remains unclear, although it has been established, in vitro or by using nerve…”
Get full text

Lipid-dependent bidirectional traffic of apolipoprotein B in polarized enterocytes by Morel, Etienne, Demignot, Sylvie, Chateau, Danielle, Chambaz, Jean, Rousset, Monique, Delers, François

“…Enterocytes are highly polarized cells that transfer nutrients across the intestinal epithelium from the apical to the basolateral pole. Apolipoprotein B…”
Get full text

Human apolipoprotein A-II associates with triglyceride-rich lipoproteins in plasma and impairs their catabolism by Dugué-Pujol, Sonia, Rousset, Xavier, Pastier, Danièle, Quang, Nhuan Tran, Pautre, Virginie, Chambaz, Jean, Chabert, Michèle, Kalopissis, Athina-Despina

“…Postprandial hypertriglyceridemia and low plasma HDL levels, which are principal features of the metabolic syndrome, are displayed by transgenic mice…”
Get full text

HNF-4-dependent Induction of Apolipoprotein A-IV Gene Transcription by an Apical Supply of Lipid Micelles in Intestinal Cells by Carrière, Véronique, Vidal, Romain, Lazou, Kristell, Lacasa, Michel, Delers, François, Ribeiro, Agnès, Rousset, Monique, Chambaz, Jean, Lacorte, Jean Marc

“…Apolipoprotein (apo) A-IV, a component of triglyceride-rich lipoproteins secreted by the small intestine, has been shown to play an important role in the…”
Get full text