Search Results - "CHAKRAVARTI, Nitin"

Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector by Colamartino, Aurelien B L, Lemieux, William, Bifsha, Panojot, Nicoletti, Simon, Chakravarti, Nitin, Sanz, Joaquín, Roméro, Hugo, Selleri, Silvia, Béland, Kathie, Guiot, Mélanie, Tremblay-Laganière, Camille, Dicaire, Renée, Barreiro, Luis, Lee, Dean A, Verhoeyen, Els, Haddad, Elie

“…NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors…”
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XPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways by Chakravarti, Nitin, Boles, Amy, Burzinski, Rachel, Sindaco, Paola, Isabelle, Colleen, McConnell, Kathleen, Mishra, Anjali, Porcu, Pierluigi

“…Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies…”
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Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target by Chen, Guo, Chakravarti, Nitin, Aardalen, Kimberly, Lazar, Alexander J, Tetzlaff, Michael T, Wubbenhorst, Bradley, Kim, Sang-Bae, Kopetz, Scott, Ledoux, Alicia A, Gopal, Y N Vashisht, Pereira, Cristiano Goncalves, Deng, Wanleng, Lee, Ju-Seog, Nathanson, Katherine L, Aldape, Kenneth D, Prieto, Victor G, Stuart, Darrin, Davies, Michael A

“…An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may…”
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The role of interleukin-15 in the development and treatment of hematological malignancies by Sindaco, Paola, Pandey, Hritisha, Isabelle, Colleen, Chakravarti, Nitin, Brammer, Jonathan Edward, Porcu, Pierluigi, Mishra, Anjali

“…Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can…”
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Cytokines in the Pathogenesis of Large Granular Lymphocytic Leukemia by Isabelle, Colleen, Boles, Amy, Chakravarti, Nitin, Porcu, Pierluigi, Brammer, Jonathan, Mishra, Anjali

“…Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults characterized by the clonal expansion of cytotoxic T/natural…”
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NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis by Shoshan, Einav, Braeuer, Russell R, Kamiya, Takafumi, Mobley, Aaron K, Huang, Li, Vasquez, Mayra E, Velazquez-Torres, Guermarie, Chakravarti, Nitin, Ivan, Cristina, Prieto, Victor, Villares, Gabriel J, Bar-Eli, Menashe

“…Nuclear factor of activated T cell (NFAT1, NFATC2) is a transcription factor that binds and positively regulates IL2 expression during T-cell activation. NFAT1…”
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MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth by Nemlich, Yael, Greenberg, Eyal, Ortenberg, Rona, Besser, Michal J, Barshack, Iris, Jacob-Hirsch, Jasmine, Jacoby, Elad, Eyal, Eran, Rivkin, Ludmila, Prieto, Victor G, Chakravarti, Nitin, Duncan, Lyn M, Kallenberg, David M, Galun, Eitan, Bennett, Dorothy C, Amariglio, Ninette, Bar-Eli, Menashe, Schachter, Jacob, Rechavi, Gideon, Markel, Gal

“…Some solid tumors have reduced posttranscriptional RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes, but the functional significance of this…”
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Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity by Naeimi Kararoudi, Meisam, Tullius, Brian P., Chakravarti, Nitin, Pomeroy, Emily J., Moriarity, Branden S., Beland, Kathie, Colamartino, Aurelien B.L., Haddad, Elie, Chu, Yaya, Cairo, Mitchell S., Lee, Dean A.

“…Cancer immunotherapy using genetically modified immune cells such as those expressing chimeric antigen receptors has shown dramatic outcomes in patients with…”
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Targeting constitutive and interleukin‐6‐inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane) by Chakravarti, Nitin, Myers, Jeffrey N., Aggarwal, Bharat B.

“…Numerous reports suggest that interleukin‐6 (IL‐6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell‐signaling protein,…”
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Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells by Chakravarti, Nitin, Kadara, Humam, Yoon, Do-Jun, Shay, Jerry W, Myers, Jeffrey N, Lotan, Dafna, Sonenberg, Nahum, Lotan, Reuben

“…Curcumin has shown some promise in the prevention of oral carcinogenesis by mechanism(s) that are still not completely resolved. Messenger RNA translation is…”
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The Nuclear Transcription Factor κB/bcl-2 Pathway Correlates with Pathologic Complete Response to Doxorubicin-Based Neoadjuvant Chemotherapy in Human Breast Cancer by BUCHHOLZ, Thomas A, GARG, Amit K, SAHIN, Aysegul A, CHAKRAVARTI, Nitin, AGGARWAL, Bharat B, ESTEVA, Francisco J, KUERER, Henry M, SINGLETARY, S. Eva, HORTOBAGYI, Gabriel N, PUSZTAI, Lajos, CRISTOFANILLI, Massimo

“…Purpose: Molecular factors involved in apoptosis may affect breast cancer response to chemotherapy. Herein, we studied the nuclear factor κB (NF-κB)/bcl-2…”
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Decreased Expression of Retinoid Receptors in Melanoma: Entailment in Tumorigenesis and Prognosis by CHAKRAVARTI, Nitin, LOTAN, Reuben, DIWAN, Abdul H, WARNEKE, Carla L, JOHNSON, Marcella M, PRIETO, Victor G

“…Purpose: Retinoids inhibit proliferation and induce differentiation in melanoma cells. Retinoic acid receptors (RAR) and retinoid X receptors (RXR) mediate the…”
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Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma by Mundy-Bosse, Bethany, Denlinger, Nathan, McLaughlin, Eric, Chakravarti, Nitin, Hwang, Susan, Chen, Li, Mao, Hsiaoyin Charlene, Kline, David, Youssef, Youssef, Kohnken, Rebecca, Lee, Dean Anthony, Lozanski, Gerard, Freud, Aharon G., Porcu, Pierluigi, William, Basem, Caligiuri, Michael A., Mishra, Anjali

“…•Paradoxically higher NK-cell activity in CTCL patients is associated with increased expression of phosphorylated STAT5.•These highly effective NK cells are…”
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Implications of Methylation Patterns of Cancer Genes in Salivary Gland Tumors by WILLIAMS, Michelle D, CHAKRAVARTI, Nitin, KIES, Merrill S, MARUYA, Shin-Lchiro, MYERS, Jeffrey N, HAVILAND, Joie C, WEBER, Randal S, LOTAN, Reuben, EL-NAGGAR, Adel K

“…Purpose: We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis…”
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Retinoic acid receptor‐alpha as a prognostic indicator in oral squamous cell carcinoma by Chakravarti, Nitin, Mathur, Meera, Bahadur, Sudhir, Shukla, Nootan Kumar, Ralhan, Ranju

“…Retinoids reverse potentially malignant lesions and inhibit the development of second primary tumors in oral cancer patients by binding to nuclear retinoid…”
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Inhibition of XPO1 with Selinexor (KPT-330) triggers apoptosis in cutaneous T-cell lymphoma (CTCL) by activating the p53-p21 and p27 pathways by Chakravarti, Nitin, Boles, Amy, Sindaco, Paola, Isabelle, Colleen, McConnell, Kathleen, Burzinski, Rachel, Mishra, Anjali, Porcu, Pierluigi

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Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells by Schafer, Jolie R., Salzillo, Travis C., Chakravarti, Nitin, Kararoudi, Meisam Naeimi, Trikha, Prashant, Foltz, Jennifer A., Wang, Ruoning, Li, Shulin, Lee, Dean A.

“…The mechanism by which natural killer (NK) cell education results in licensed NK cells with heightened effector function against missing self-targets is not…”
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Pathobiology and Targeting of CD38 in Cutaneous T-Cell Lymphoma by Isabelle, Colleen, Boles, Amy, McConnell, Kathleen, Keller, Robyn, Cheslow, Lara, Xu, Jonathan, Waldman, Scott, Chakravarti, Nitin, Porcu, Pierluigi, Nikbakht, Neda, Mishra, Anjali

“…Introduction: Cutaneous T-cell lymphoma (CTCL) is a malignancy of mature CD4+ T-cells that primarily affects the skin. Despite a wide variety of topical and…”
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Therapeutic Potential and Role of CD38 in Cutaneous T-Cell Lymphoma Pathogenesis by Isabelle, Colleen, McConnell, Kathleen, Boles, Amy E, Brammer, Jonathan E, Berge, Robyn, Portocarrero, Carla, Chakravarti, Nitin, Porcu, Pierluigi, Nikbakht, Neda, Mishra, Anjali

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Improved Bone Marrow Homing of NK Cells through PM21 Particle Stimulated Enhancement of Fucosylation of E-Selectin Ligand by Oyer, Jeremiah, Chakravarti, Nitin, Igarashi, Robert, Altamore, Deborah, Lee, Dean Anthony, Copik, Alicja Joanna

“…Introduction Therapy of marrow borne disease such as leukemias or myelomas require the eradication of tumor cells that are resident in the bone marrow. Cell…”
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