Search Results - "CHAIKEN, I"

An overview of affinity chromatography by Wilchek, M, Chaiken, I

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Antibody 17b Binding at the Coreceptor Site Weakens the Kinetics of the Interaction of Envelope Glycoprotein gp120 with CD4 by Zhang, Wentao, Godillot, Alexis P, Wyatt, Richard, Sodroski, Joseph, Chaiken, Irwin

“…HIV-1 utilizes CD4 and the chemokine coreceptor for viral entry. The coreceptor CCR5 binding site on gp120 partially overlaps with the binding epitope of 17b,…”
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Controlled formation of model homo- and heterodimer coiled coil polypeptides by Graddis, Thomas J, Myszka, David G, Chaiken, Irwin M

“…Sequence-simplified coiled coil polypeptides were synthesized and their folding properties characterized in order to define the role of charged border residues…”
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Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design by Chaiken, Irwin M., Williams, William V.

“…Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the…”
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Interpreting Complex Binding Kinetics from Optical Biosensors: A Comparison of Analysis by Linearization, the Integrated Rate Equation, and Numerical Integration by Morton, T.A., Myszka, D.G., Chaiken, I.M.

“…The binding kinetics recorded for many interactions using BIAcore and IAsys optical biosensors do not fit a simple bimolecular interaction model (A + B ⇄ AB)…”
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Design and Characterization of an Intramolecular Antiparallel Coiled Coil Peptide by Myszka, David G, Chaiken, Irwin M

“…A 56-residue polypeptide was designed to fold into a stable intramolecular antiparallel coiled coil, referred to as a coiled coil stem loop. The antiparallel…”
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Nature of the Charged-Group Effect on the Stability of the C-Peptide Helix by Shoemaker, Kevin R., Kim, Peter S., Brems, David N., Marqusee, Susan, York, Eunice J., Chaiken, Irwin M., Stewart, John M., Baldwin, Robert L.

“…The residues responsible for the pH-dependent stability of the helix formed by the isolated C-peptide (residues 1-13 of ribonuclease A) have been identified by…”
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Cyclic peptide interleukin 5 antagonists mimic CD turn recognition epitope for receptor α by Ruchala, Piotr, Varadi, Gyorgyi, Ishino, Tetsuya, Scibek, Jeffery, Bhattacharya, Madhushree, Urbina, Cecilia, Ryk, Donald Van, Uings, Iain, Chaiken, Irwin

“…The cyclic peptide AF17121 (Ac‐VDECWRIIASHTWFCAEE) that inhibits interleukin 5 (IL‐5) function and IL‐5 receptor α‐chain (IL‐5Rα) binding has been derived from…”
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Mode of Action for Linear Peptide Inhibitors of HIV-1 gp120 Interactions by Biorn, Alyssa C, Cocklin, Simon, Madani, Navid, Si, Zhihai, Ivanovic, Tijana, Samanen, James, Van Ryk, Donald I, Pantophlet, Ralph, Burton, Dennis R, Freire, Ernesto, Sodroski, Joseph, Chaiken, Irwin M

“…The linear peptide 12p1 (RINNIPWSEAMM) was previously isolated from a phage display library and was found to inhibit interaction of HIV-1 gp120 with both CD4…”
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Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor by Myszka, David G., Morton, Thomas A., Doyle, Michael L., Chaiken, Irwin M.

“…Using BIAcore™ technology, we determined the rate constants for a protein antigen-antibody interaction that was mass transport limited on the optical…”
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Mutagenesis in the C-Terminal Region of Human Interleukin 5 Reveals a Central Patch for Receptor α Chain Recognition by Morton, Thomas, Li, Jun, Cook, Richard, Chaiken, Irwin

“…Cassette mutagenesis was used to identify side chains in human interleukin 5 (hIL-5) that mediate binding to hIL-5 receptor α chain (hIL-5Rα). A series of…”
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Multisite Mutagenesis of Interleukin 5 Differentiates Sites for Receptor Recognition and Receptor Activation by Plugariu, Carmela G, Wu, Sheng-Jiun, Zhang, Wentao, Chaiken, Irwin

“…Multisite mutagenesis of single-chain and monomeric forms of human interleukin 5 (IL-5) was performed to investigate mechanistic features of receptor…”
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Phage randomization in a charybdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequences by Li, C., Dowd, C.S., Zhang, W., Chaiken, I.M.

“…: Binding of HIV‐1 gp120 to T‐cell receptor CD4 initiates conformational changes in the viral envelope that trigger viral entry into host cells. Phage epitope…”
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Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm by Leavitt, Stephanie A, SchOn, Arne, Klein, Jeffrey C, Manjappara, Uma, Chaiken, Irwin M, Freire, Ernesto

“…During the course of infection, a subset of HIV-1 proteins interacts with multiple cellular partners, sometimes in a hierarchical or sequential way. These…”
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β-Turn Phe in HIV-1 Env Binding Site of CD4 and CD4 Mimetic Miniprotein Enhances Env Binding Affinity but Is Not Required for Activation of Co-Receptor/17b Site by Dowd, Cynthia S, Leavitt, Stephanie, Babcock, Gregory, Godillot, Alexis P, Van Ryk, Don, Canziani, Gabriela A, Sodroski, Joseph, Freire, Ernesto, Chaiken, Irwin M

“…HIV-1 enters a host cell after an initial interaction between viral envelope glycoprotein gp120 and cell surface receptor CD4, followed by a second interaction…”
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Structural requirements of peptide hormone binding for peptide-potentiated self-association of bovine neurophysin II by Fassina, G, Chaiken, I M

“…Site-specific, truncated, and sequence-simplified analogs of the hormone [Arg8]vasopressin were investigated for the relationship between their abilities to…”
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Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1 by Sheng, N, Fairbanks, M B, Heinrikson, R L, Canziani, G, Chaiken, I M, Mosser, D M, Zhang, H, Colman, R W

“…High molecular weight kininogen (HK) and its cleaved form (HKa) have been shown to bind to neutrophils. Based on studies using monoclonal antibodies (mAbs), we…”
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Molecular properties of the oxytocin/bovine neurophysin biosynthetic precursor. Studies using a semisynthetic precursor by Kanmera, T, Chaiken, I M

“…An oxytocin/bovine neurophysin I biosynthetic precursor, [N epsilon-diacetimidyl-30,71, des-His106]pro-OT/BNPI, was synthesized from a synthetic oxytocinyl…”
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The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site by Prévost, J, Tolbert, W., Medjahed, H., Sherburn, R., Madani, N., Zoubchenok, D., Gendron-Lepage, G., Gaffney, A., Grenier, M., Kirk, S., Vergara, N., Han, C., Mann, B., Chénine, A., Ahmed, A., Chaiken, I., Kirchhoff, F., Hahn, B., Haim, H., Abrams, C., Smith, A., Sodroski, J., Pazgier, M., Finzi, A.

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites by Kwong, Peter D, Doyle, Michael L, Casper, David J, Cicala, Claudia, Leavitt, Stephanie A, Majeed, Shahzad, Steenbeke, Tavis D, Venturi, Miro, Chaiken, Irwin, Fung, Michael, Katinger, Hermann, Parren, Paul W. I. H, Robinson, James, Van Ryk, Donald, Wang, Liping, Burton, Dennis R, Freire, Ernesto, Wyatt, Richard, Sodroski, Joseph, Hendrickson, Wayne A, Arthos, James

“…The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent on its avoidance of antibody-mediated neutralization. The virus…”
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