Search Results - "CHABOT, Sophie"

Characterization and Validation of a Chronic Model of Cyclophosphamide-Induced Interstitial Cystitis/Bladder Pain Syndrome in Rats by Augé, Céline, Gamé, Xavier, Vergnolle, Nathalie, Lluel, Philippe, Chabot, Sophie

“…Interstitial cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease characterized by visceral pain and voiding symptoms. IC/BPS is still an…”
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Potassium channels in pulmonary arterial hypertension by Boucherat, Olivier, Chabot, Sophie, Antigny, Fabrice, Perros, Frédéric, Provencher, Steeve, Bonnet, Sébastien

“…Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with various origins. All forms of PAH share a common pulmonary arteriopathy…”
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Targeted electro-delivery of oligonucleotides for RNA interference: siRNA and antimiR by Chabot, Sophie, Teissié, Justin, Golzio, Muriel

“…For more than a decade, the understanding of RNA interference (RNAi) has been a growing field of interest. Micro-RNAs (miRNAs) are small regulatory RNAs that…”
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HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension by Boucherat, Olivier, Chabot, Sophie, Paulin, Roxane, Trinh, Isabelle, Bourgeois, Alice, Potus, François, Lampron, Marie-Claude, Lambert, Caroline, Breuils-Bonnet, Sandra, Nadeau, Valérie, Paradis, Renée, Goncharova, Elena A., Provencher, Steeve, Bonnet, Sébastien

“…Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary…”
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Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients by d’Aldebert, Emilie, Quaranta, Muriel, Sébert, Morgane, Bonnet, Delphine, Kirzin, Sylvain, Portier, Guillaume, Duffas, Jean-Pierre, Chabot, Sophie, Lluel, Philippe, Allart, Sophie, Ferrand, Audrey, Alric, Laurent, Racaud-Sultan, Claire, Mas, Emmanuel, Deraison, Céline, Vergnolle, Nathalie

“…Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial defects drive, at least in part, some of the pathology. We reconstituted…”
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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease‐activated receptor 1‐ and protease‐activated receptor 4‐dependent mechanism by Sébert, Morgane, Denadai‐Souza, Alexandre, Quaranta, Muriel, Racaud‐Sultan, Claire, Chabot, Sophie, Lluel, Philippe, Monjotin, Nicolas, Alric, Laurent, Portier, Guillaume, Kirzin, Sylvain, Bonnet, Delphine, Ferrand, Audrey, Vergnolle, Nathalie

“…Background and Purpose Thrombin is massively released upon tissue damage associated with bleeding or chronic inflammation. The effects of this thrombin on…”
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FAK alternative splice mRNA variants expression pattern in colorectal cancer by Devaud, Christel, Tilkin‐Mariamé, Anne‐Françoise, Vignolle‐Vidoni, Alix, Souleres, Philippine, Denadai‐Souza, Alexandre, Rolland, Corinne, Duthoit, Christine, Blanpied, Catherine, Chabot, Sophie, Bouillé, Pascale, Lluel, Philippe, Vergnolle, Nathalie, Racaud‐Sultan, Claire, Ferrand, Audrey

“…The Focal adhesion kinase (FAK) is a ubiquitous cytoplasmic tyrosine‐kinase promoting tumor progression and metastasis processes by acting in cancer cells and…”
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TLRs Regulate the Gatekeeping Functions of the Intestinal Follicle-Associated Epithelium by Chabot, Sophie, Wagner, Jessica S, Farrant, Stephanie, Neutra, Marian R

“…Initiation of adaptive mucosal immunity occurs in organized mucosal lymphoid tissues such as Peyer's patches of the small intestine. Mucosal lymphoid follicles…”
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Pre-clinical investigation of the synergy effect of interleukin-12 gene-electro-transfer during partially irreversible electropermeabilization against melanoma by Pasquet, Lise, Bellard, Elisabeth, Chabot, Sophie, Markelc, Bostjan, Rols, Marie-Pierre, Teissie, Justin, Golzio, Muriel

“…Melanoma is a very aggressive skin tumor that can be cured when diagnosed and treated in its early stages. However, at the time of identification, the tumor is…”
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Impact of Cernitin™ on induced chronic prostatitis in animal model for understanding management of lower urinary tract symptoms by Chabot, Sophie, Dizeyi, Nishtman, Ramnemark, Lena, Lluel, Philippe, Abrahamsson, Per-Anders, Grabe, Magnus

“…•CernitinTM inhibit enzyme COX-2 and reduce the production of prostaglands which are known to cause pain during inflammation.•Simultaneously,…”
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Effects of Flagellin on the Functions of Follicle-Associated Epithelium by Chabot, Sophie M., Shawi, May, Eaves-Pyles, Tonyia, Neutra, Marian R.

“…Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid…”
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A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor by Chabot, Sophie, Jabrane-Ferrat, Nabila, Bigot, Karine, Tabiasco, Julie, Provost, Alexandra, Golzio, Muriel, Noman, Muhammad Zaeem, Giustiniani, Jérôme, Bellard, Elisabeth, Brayer, Stéphanie, Aguerre-Girr, Maryse, Meggetto, Fabienne, Giuriato, Sylvie, Malecaze, François, Galiacy, Stéphane, Jaïs, Jean-Philippe, Chose, Olivier, Kadouche, Jean, Chouaib, Salem, Teissié, Justin, Abitbol, Marc, Bensussan, Armand, Le Bouteiller, Philippe

“…Angiogenesis plays an essential role in several diseases of the eye and in the growth of solid tumors, but existing antiangiogenic therapies have limited…”
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Nucleic acids electro-transfer: from bench to bedside by Chabot, Sophie, Rosazza, Christelle, Golzio, Muriel, Zumbusch, Andreas, Teissié, Justin, Rols, Marie-Pierre

“…There are a number of stigmas attached to the development of antitumor drugs such as their safe and efficient delivery into target cells or tissues. The one…”
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TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces by Chabot, Sophie M, Chernin, Tyler S, Shawi, May, Wagner, Jessica, Farrant, Stephanie, Burt, David S, Cyr, Sonya, Neutra, Marian R

“…Abstract Proteosome-based vaccines have TLR2-based adjuvant activity and show promise for mucosal immunization. We examined the effects of proteosomes on…”
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Delivery of RNAi-Based Oligonucleotides by Electropermeabilization by Chabot, Sophie, Pelofy, Sandrine, Teissié, Justin, Golzio, Muriel

“…For more than a decade, understanding of RNA interference (RNAi) has been a growing field of interest. The potent gene silencing ability that small…”
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Inhibitory Effects of Surfactant Protein A on Surfactant Phospholipid Hydrolysis by Secreted Phospholipases A2 by Chabot, Sophie, Koumanov, Kamen, Lambeau, Gerard, Gelb, Michael H, Balloy, Viviane, Chignard, Michel, Whitsett, Jeffrey A, Touqui, Lhousseine

“…Hydrolysis of surfactant phospholipids by secreted phospholipases A(2) (sPLA(2)) contributes to surfactant dysfunction in acute respiratory distress syndrome…”
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LNA-based Oligonucleotide Electrotransfer for miRNA Inhibition by Chabot, Sophie, Orio, Julie, Castanier, Romain, Bellard, Elisabeth, Nielsen, Søren J, Golzio, Muriel, Teissié, Justin

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Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension by Boucherat, Olivier, Peterlini, Thibaut, Bourgeois, Alice, Nadeau, Valérie, Breuils-Bonnet, Sandra, Boilet-Molez, Stéphanie, Potus, François, Meloche, Jolyane, Chabot, Sophie, Lambert, Caroline, Tremblay, Eve, Chae, Young Chan, Altieri, Dario C, Sutendra, Gopinath, Michelakis, Evangelos D, Paulin, Roxane, Provencher, Steeve, Bonnet, Sébastien

“…Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with a poor prognosis and limited therapeutic options. Although the mechanisms…”
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Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension by Meloche, Jolyane, Potus, François, Vaillancourt, Mylène, Bourgeois, Alice, Johnson, Ian, Deschamps, Laure, Chabot, Sophie, Ruffenach, Grégoire, Henry, Sarah, Breuils-Bonnet, Sandra, Tremblay, Ève, Nadeau, Valérie, Lambert, Caroline, Paradis, Renée, Provencher, Steeve, Bonnet, Sébastien

“…RATIONALE:Pulmonary arterial hypertension (PAH) is a vasculopathy characterized by enhanced pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and…”
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Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension by Ruffenach, Grégoire, Chabot, Sophie, Tanguay, Virginie F, Courboulin, Audrey, Boucherat, Olivier, Potus, Francois, Meloche, Jolyane, Pflieger, Aude, Breuils-Bonnet, Sandra, Nadeau, Valérie, Paradis, Renée, Tremblay, Eve, Girerd, Barbara, Hautefort, Aurélie, Montani, David, Fadel, Elie, Dorfmuller, Peter, Humbert, Marc, Perros, Frédéric, Paulin, Roxane, Provencher, Steeve, Bonnet, Sébastien

“…Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). This is sustained in time…”
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