Search Results - "CEULEMANS, Berten"

Successful use of fenfluramine as an add-on treatment for Dravet syndrome by Ceulemans, Berten, Boel, Marc, Leyssens, Katrien, Van Rossem, Carolin, Neels, Pieter, Jorens, Philippe G., Lagae, Lieven

“…Summary Purpose:  Despite the development of new antiepileptic drugs, Dravet syndrome frequently remains therapy resistant and is a catastrophic epilepsy…”
Get full text

Developmental unilateral facial palsy in a newborn: six cases and literature review by Decraene, Laura, Boudewyns, An, Venstermans, Caroline, Ceulemans, Berten

“…Unilateral facial palsy in a newborn is rarely caused by a developmental defect. It occurs either isolated or in the context of a syndrome. This article…”
Get full text

Therapeutic drug monitoring of fenfluramine in clinical practice: Pharmacokinetic variability and impact of concomitant antiseizure medications by Schoonjans, An‐Sofie, Roosens, Laurence, Dewals, Wendy, Paelinck, Bernard P., Ceulemans, Berten

“…Objective This study was undertaken to determine the plasma concentration and pharmacokinetic variability of fenfluramine (FFA) and its main active metabolite…”
Get full text

KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy by Weckhuysen, Sarah, Mandelstam, Simone, Suls, Arvid, Audenaert, Dominique, Deconinck, Tine, Claes, Lieve R.F., Deprez, Liesbet, Smets, Katrien, Hristova, Dimitrina, Yordanova, Iglika, Jordanova, Albena, Ceulemans, Berten, Jansen, An, Hasaerts, Danièle, Roelens, Filip, Lagae, Lieven, Yendle, Simone, Stanley, Thorsten, Heron, Sarah E., Mulley, John C., Berkovic, Samuel F., Scheffer, Ingrid E., Peter de Jonghe

“…Objective: KCNQ2 and KCNQ3 mutations are known to be responsible for benign familial neonatal seizures (BFNS). A few reports on patients with a KCNQ2 mutation…”
Get full text

Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies by Carvill, Gemma L., Engel, Krysta L., Ramamurthy, Aishwarya, Cochran, J. Nicholas, Roovers, Jolien, Stamberger, Hannah, Lim, Nicholas, Schneider, Amy L., Hollingsworth, Georgie, Holder, Dylan H., Regan, Brigid M., Lawlor, James, Lagae, Lieven, Ceulemans, Berten, Bebin, E. Martina, Nguyen, John, Striano, Pasquale, Zara, Federico, Helbig, Ingo, Møller, Rikke S., von Spiczak, Sarah, Muhle, Hiltrud, Caglayan, Hande, Sterbova, Katalin, Craiu, Dana, Hoffman, Dorota, Lehesjoki, Anna-Elina, Selmer, Kaja, Depienne, Christel, Lemke, Johannes, Marini, Carla, Guerrini, Renzo, Neubauer, Bernd, Talvik, Tiina, Leguern, Eric, de Jonghe, Peter, Weckhuysen, Sarah, Barsh, Gregory S., Weckhuysen, Sarah, Meisler, Miriam, Berkovic, Samuel F., De Jonghe, Peter, Scheffer, Ingrid E., Myers, Richard M., Cooper, Gregory M., Mefford, Heather C.

“…Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies characterized by refractory seizures and developmental impairment…”
Get full text

Treatment of Focal-Onset Seizures in Children: Should This Be More Etiology-Driven? by Aeby, Alec, Ceulemans, Berten, Lagae, Lieven

“…To accelerate the process of licensing antiseizure medication (ASM) in children, extrapolation of efficacy data for focal-onset seizures from adults to…”
Get full text

Low-dose fenfluramine in the treatment of neurologic disorders: experience in Dravet syndrome by Schoonjans, An-Sofie, Lagae, Lieven, Ceulemans, Berten

“…In this paper, we review the experience with fenfluramine in epileptic and other paroxysmal disorders. Since the best available data are from the treatment of…”
Get full text

Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial by Sullivan, Joseph, Lagae, Lieven, Cross, J Helen, Devinsky, Orrin, Guerrini, Renzo, Knupp, Kelly G, Laux, Linda, Nikanorova, Marina, Polster, Tilman, Talwar, Dinesh, Ceulemans, Berten, Nabbout, Rima, Farfel, Gail M, Galer, Bradley S, Gammaitoni, Arnold R, Lock, Michael, Agarwal, Anupam, Scheffer, Ingrid E

“…To assess the safety and efficacy of fenfluramine in the treatment of convulsive seizures in patients with Dravet syndrome. This multicenter, randomized,…”
Get full text

Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine by Zhang, Yifan, Kecskés, Angéla, Copmans, Daniëlle, Langlois, Mélanie, Crawford, Alexander D, Ceulemans, Berten, Lagae, Lieven, de Witte, Peter A M, Esguerra, Camila V

“…Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene…”
Get full text

Lessons learned from 40 novel PIGA patients and a review of the literature by Bayat, Allan, Knaus, Alexej, Pendziwiat, Manuela, Afenjar, Alexandra, Barakat, Tahsin Stefan, Bosch, Friedrich, Callewaert, Bert, Calvas, Patrick, Ceulemans, Berten, Chassaing, Nicolas, Depienne, Christel, Endziniene, Milda, Ferreira, Carlos R., Moura de Souza, Carolina Fischinger, Freihuber, Cécile, Ganesan, Shiva, Gataullina, Svetlana, Guerrini, Renzo, Guerrot, Anne‐Marie, Hansen, Lars, Jezela‐Stanek, Aleksandra, Karsenty, Caroline, Kievit, Anneke, Kooy, Frank R., Korff, Christian M., Kragh Hansen, Johanne, Larsen, Martin, Layet, Valérie, Lesca, Gaetan, McBride, Kim L., Meuwissen, Marije, Mignot, Cyril, Montomoli, Martino, Moore, Hannah, Naudion, Sophie, Nava, Caroline, Nougues, Marie‐Christine, Parrini, Elena, Pastore, Matthew, Schelhaas, Jurgen H., Skinner, Steven, Szczałuba, Krzysztoł, Thomas, Ashley, Thomassen, Mads, Tranebjærg, Lisbeth, Slegtenhorst, Marjon, Wolfe, Lynne A., Lal, Dennis, Gardella, Elena, Bomme Ousager, Lilian, Brünger, Tobias, Helbig, Ingo, Krawitz, Peter, Møller, Rikke S.

“…Objective To define the phenotypic spectrum of phosphatidylinositol glycan class A protein (PIGA)‐related congenital disorder of glycosylation (PIGA‐CDG) and…”
Get full text

Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders by Mochel, Fanny, Rastetter, Agnès, Ceulemans, Berten, Platzer, Konrad, Yang, Sandra, Shinde, Deepali N, Helbig, Katherine L, Lopergolo, Diego, Mari, Francesca, Renieri, Alessandra, Benetti, Elisa, Canitano, Roberto, Waisfisz, Quinten, Plomp, Astrid S, Huisman, Sylvia A, Wilson, Golder N, Cathey, Sara S, Louie, Raymond J, Gaudio, Daniela Del, Waggoner, Darrel, Kacker, Shawn, Nugent, Kimberly M, Roeder, Elizabeth R, Bruel, Ange-Line, Thevenon, Julien, Ehmke, Nadja, Horn, Denise, Holtgrewe, Manuel, Kaiser, Frank J, Kamphausen, Susanne B, Abou Jamra, Rami, Weckhuysen, Sarah, Dalle, Carine, Depienne, Christel

“…KCNN2 encodes the small conductance calcium-activated potassium channel 2 (SK2). Rodent models with spontaneous Kcnn2 mutations show abnormal gait and…”
Get full text

Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1 by Suls, Arvid, Mullen, Saul A., Weber, Yvonne G., Verhaert, Kristien, Ceulemans, Berten, Guerrini, Renzo, Wuttke, Thomas V., Salvo-Vargas, Alberto, Deprez, Liesbet, Claes, Lieve R. F., Jordanova, Albena, Berkovic, Samuel F., Lerche, Holger, De Jonghe, Peter, Scheffer, Ingrid E.

“…Absence epilepsies of childhood are heterogeneous with most cases following complex inheritance. Those cases with onset before 4 years of age represent a…”
Get full text

A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome by Ligsay, Andrew, Van Dijck, Anke, Nguyen, Danh V, Lozano, Reymundo, Chen, Yanjun, Bickel, Erika S, Hessl, David, Schneider, Andrea, Angkustsiri, Kathleen, Tassone, Flora, Ceulemans, Berten, Kooy, R Frank, Hagerman, Randi J

“…Gamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABA receptor…”
Get full text

De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy by Claes, Lieve, Del-Favero, Jurgen, Ceulemans, Berten, Lagae, Lieven, Van Broeckhoven, Christine, De Jonghe, Peter

“…Severe myoclonic epilepsy of infancy (SMEI) is a rare disorder that occurs in isolated patients. The disease is characterized by generalized tonic, clonic, and…”
Get full text

Pseudomonas aeruginosa in children with cerebral palsy: a prospective study by Romaen, Katrien, Van Ussel, Isabelle, Van Rossem, Carolin, Kenis, Sandra, Ceulemans, Berten, Van Hoorenbeeck, Kim, Verhulst, Stijn

“…Introduction Children with cerebral palsy (CP) often present with chronic respiratory symptoms. Pseudomonas aeruginosa (PA), is a known pathogen associated…”
Get full text

Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy by Ceulemans, Berten P.G.M, Claes, Lieve R.F, Lagae, Lieven G

“…Mutations in the α-subunit of the first neuronal sodium channel gene SCN1A have been described in isolated patients with severe myoclonic epilepsy in infancy…”
Get full text

Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial by Weyns, Anne-Sophie, Verlaet, Annelies A.J., Breynaert, Annelies, Naessens, Tania, Fransen, Erik, Verhelst, Helene, Van West, Dirk, Van Ingelghem, Ingrid, Jonckheere, An I., Beysen, Diane, Kenis, Sandra, Moens, Els, van Roest, Aalt P.J., Savelkoul, Huub F.J., De Bruyne, Tess, Pieters, Luc, Ceulemans, Berten, Hermans, Nina

“…[Display omitted] •Assessing the value of French Maritime Pine Bark Extract (PBE) in ADHD therapy as compared to methylphenidate (MPH) and placebo in a 10-week…”
Get full text

Childhood chronic inflammatory demyelinating polyneuroradiculopathy – Three cases and a review of the literature by Riekhoff, Antoinetta G.M, Jadoul, Chris, Mercelis, Rudy, Cras, Patrick, Ceulemans, Berten P.G.M

“…Abstract Background Chronic inflammatory demyelinating polyneuroradiculopathy (CIDP) is an autoimmune disease of the peripheral nervous system, causing…”
Get full text

Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly by Stouffs, Katrien, Verloo, Patrick, Brock, Stefanie, Régal, Luc, Beysen, Diane, Ceulemans, Berten, Jansen, Anna C, Meuwissen, Marije E C

“…NEDD4L encodes an ubiquitin ligase which is expressed in the cortex and ventricular zone of the fetal brain. Missense variants in NEDD4L have been reported in…”
Get full text

Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 2: Oxidative Stress and Immunological Modulation by Weyns, Anne-Sophie, Verlaet, Annelies A.J., Van Herreweghe, Maxim, Breynaert, Annelies, Fransen, Erik, De Meester, Ingrid, Logie, Emilie, Vanden Berghe, Wim, Verhelst, Helene, Van West, Dirk, Van Ingelghem, Ingrid, Jonckheere, An I., Beysen, Diane, Kenis, Sandra, Moens, Els, van Roest, Aalt P.J., Savelkoul, Huub F.J., De Bruyne, Tess, Pieters, Luc, Ceulemans, Berten, Hermans, Nina

“…[Display omitted] •French Maritime Pine Bark Extract (PBE) in Attention-Deficit Hyperactivity Disorder (ADHD) compared to methylphenidate (MPH) and…”
Get full text