Search Results - "CECCONI, Francesco"

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death by Cecconi, Francesco, Levine, Beth

“…Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell…”
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Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications by Nazio, Francesca, Bordi, Matteo, Cianfanelli, Valentina, Locatelli, Franco, Cecconi, Francesco

“…Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions strictly depend on cancer ontogenesis, progression, and type. For…”
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Caspase-3 in the central nervous system: beyond apoptosis by D’Amelio, Marcello, Sheng, Morgan, Cecconi, Francesco

“…Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its…”
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Autophagy and the Cell Cycle: A Complex Landscape by Mathiassen, Søs Grønbæk, De Zio, Daniela, Cecconi, Francesco

“…Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in double-membrane vesicles and delivered to the lysosome for…”
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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 by Nazio, Francesca, Strappazzon, Flavie, Antonioli, Manuela, Bielli, Pamela, Cianfanelli, Valentina, Bordi, Matteo, Gretzmeier, Christine, Dengjel, Joern, Piacentini, Mauro, Fimia, Gian Maria, Cecconi, Francesco

“…Autophagy is important in the basal or stress-induced clearance of bulk cytosol, damaged organelles, pathogens and selected proteins by specific vesicles, the…”
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Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver by Martinez-Lopez, Nuria, Garcia-Macia, Marina, Sahu, Srabani, Athonvarangkul, Diana, Liebling, Emily, Merlo, Paola, Cecconi, Francesco, Schwartz, Gary J., Singh, Rajat

“…The integrative physiology of inter-organ communication in lipophagy regulation is not well understood. Lipophagy and the cytosolic lipases ATGL and HSL…”
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Mitochondrial dismissal in mammals, from protein degradation to mitophagy by Campello, Silvia, Strappazzon, Flavie, Cecconi, Francesco

“…Mitochondria are double-membraned highly dynamic organelles; the shape, location and function of which are determined by a constant balance between opposing…”
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Autophagy in malignant transformation and cancer progression by Galluzzi, Lorenzo, Pietrocola, Federico, Bravo-San Pedro, José Manuel, Amaravadi, Ravi K, Baehrecke, Eric H, Cecconi, Francesco, Codogno, Patrice, Debnath, Jayanta, Gewirtz, David A, Karantza, Vassiliki, Kimmelman, Alec, Kumar, Sharad, Levine, Beth, Maiuri, Maria Chiara, Martin, Seamus J, Penninger, Josef, Piacentini, Mauro, Rubinsztein, David C, Simon, Hans-Uwe, Simonsen, Anne, Thorburn, Andrew M, Velasco, Guillermo, Ryan, Kevin M, Kroemer, Guido

“…Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against…”
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HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα by Di Rita, Anthea, Peschiaroli, Angelo, D′Acunzo, Pasquale, Strobbe, Daniela, Hu, Zehan, Gruber, Jens, Nygaard, Mads, Lambrughi, Matteo, Melino, Gerry, Papaleo, Elena, Dengjel, Jörn, El Alaoui, Said, Campanella, Michelangelo, Dötsch, Volker, Rogov, Vladimir V., Strappazzon, Flavie, Cecconi, Francesco

“…The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour…”
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Autophagic and apoptotic response to stress signals in mammalian cells by Ferraro, Elisabetta, Cecconi, Francesco

“…Autophagy is a highly conserved catabolic programme for degrading proteins and organelles. This process has been shown to act as a pro-survival or pro-death…”
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Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans by Schiavi, Alfonso, Maglioni, Silvia, Palikaras, Konstantinos, Shaik, Anjumara, Strappazzon, Flavie, Brinkmann, Vanessa, Torgovnick, Alessandro, Castelein, Natascha, De Henau, Sasha, Braeckman, Bart P., Cecconi, Francesco, Tavernarakis, Nektarios, Ventura, Natascia

“…Frataxin is a nuclear-encoded mitochondrial protein involved in the biogenesis of Fe-S-cluster-containing proteins and consequently in the functionality of the…”
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Ambra1 at a glance by Cianfanelli, Valentina, De Zio, Daniela, Di Bartolomeo, Sabrina, Nazio, Francesca, Strappazzon, Flavie, Cecconi, Francesco

“…The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and…”
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Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells by Catalano, Myriam, D'Alessandro, Giuseppina, Lepore, Francesca, Corazzari, Marco, Caldarola, Sara, Valacca, Cristina, Faienza, Fiorella, Esposito, Vincenzo, Limatola, Cristina, Cecconi, Francesco, Di Bartolomeo, Sabrina

“…Cell migration and invasion are highly regulated processes involved in both physiological and pathological conditions. Here we show that autophagy modulation…”
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Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation by Nazio, Francesca, Carinci, Marianna, Valacca, Cristina, Bielli, Pamela, Strappazzon, Flavie, Antonioli, Manuela, Ciccosanti, Fabiola, Rodolfo, Carlo, Campello, Silvia, Fimia, Gian Maria, Sette, Claudio, Bonaldo, Paolo, Cecconi, Francesco

“…Autophagy is an intracellular degradation pathway whose levels are tightly controlled to secure cell homeostasis. Unc-51-like kinase 1 (ULK1) is a conserved…”
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A gene toolbox for monitoring autophagy transcription by Bordi, Matteo, De Cegli, Rossella, Testa, Beatrice, Nixon, Ralph A., Ballabio, Andrea, Cecconi, Francesco

“…Autophagy is a highly dynamic and multi-step process, regulated by many functional protein units. Here, we have built up a comprehensive and up-to-date…”
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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease by Cecconi, Francesco, D'Amelio, Marcello, Cavallucci, Virve, Middei, Silvia, Marchetti, Cristina, Pacioni, Simone, Ferri, Alberto, Diamantini, Adamo, De Zio, Daniela, Carrara, Paolo, Battistini, Luca, Moreno, Sandra, Bacci, Alberto, Ammassari-Teule, Martine, Marie, Hélène

“…In a mouse model of Alzheimer's disease, the authors find that early loss of AMPA receptors at synapses at onset of cognitive dysfunction is a result of…”
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A cross-sectional and prospective cohort study of the role of schools in the SARS-CoV-2 second wave in Italy by Gandini, Sara, Rainisio, Maurizio, Iannuzzo, Maria Luisa, Bellerba, Federica, Cecconi, Francesco, Scorrano, Luca

“…During COVID-19 pandemic, school closure has been mandated in analogy to its effect against influenza, but it is unclear whether schools are early COVID-19…”
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Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival by Russo, Rossella, Varano, Giuseppe Pasquale, Adornetto, Annagrazia, Nazio, Francesca, Tettamanti, Gianluca, Girardello, Rossana, Cianfanelli, Valentina, Cavaliere, Federica, Morrone, Luigi Antonio, Corasaniti, Maria Tiziana, Cecconi, Francesco, Bagetta, Giacinto, Nucci, Carlo

“…Autophagy, the cellular process responsible for degradation and recycling of cytoplasmic components through the autophagosomal–lysosomal pathway, is…”
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AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation by Cianfanelli, Valentina, Fuoco, Claudia, Lorente, Mar, Salazar, Maria, Quondamatteo, Fabio, Gherardini, Pier Federico, De Zio, Daniela, Nazio, Francesca, Antonioli, Manuela, D’Orazio, Melania, Skobo, Tatjana, Bordi, Matteo, Rohde, Mikkel, Dalla Valle, Luisa, Helmer-Citterich, Manuela, Gretzmeier, Christine, Dengjel, Joern, Fimia, Gian Maria, Piacentini, Mauro, Di Bartolomeo, Sabrina, Velasco, Guillermo, Cecconi, Francesco

“…Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways…”
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Do You Remember Mitochondria? by Messina, Flavia, Cecconi, Francesco, Rodolfo, Carlo

“…Dementia is one among the consequences of aging, and amnesia is often one of the most common symptoms. The lack of memory, as a consequence of both "healthy"…”
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