Search Results - "CAYLA, Mathieu"

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei by Cayla, Mathieu, McDonald, Lindsay, MacGregor, Paula, Matthews, Keith

“…The sleeping sickness parasite, , uses quorum sensing (QS) to balance proliferation and transmission potential in the mammal bloodstream. A signal transduction…”
Get full text

Differentiation granules, a dynamic regulator of T. brucei development by Cayla, Mathieu, Spanos, Christos, McWilliam, Kirsty, Waskett, Eliza, Rappsilber, Juri, Matthews, Keith R.

“…Adaptation to a change of environment is an essential process for survival, in particular for parasitic organisms exposed to a wide range of hosts. Such…”
Get full text

Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro by Rojas, Federico, Cayla, Mathieu, Matthews, Keith R

“…The ability to reproduce the developmental events of trypanosomes that occur in their mammalian host in vitro offers significant potential to assist in…”
Get full text

African trypanosomes by Cayla, Mathieu, Rojas, Federico, Silvester, Eleanor, Venter, Frank, Matthews, Keith R

“…African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa…”
Get full text

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome—Disease-Relevant or Benign? by MARINOZZI, Maria Chiara, VERGOZ, Laura, SMITH, Richard J, NORIS, Marina, HALBWACHS-MECARELLI, Lise, DONADELLI, Roberta, FREMEAUX-BACCHI, Veronique, ROUMENINA, Lubka T, RYBKINE, Tania, NGO, Stephanie, BETTONI, Serena, PASHOV, Anastas, CAYLA, Mathieu, TABARIN, Fanny, JABLONSKI, Mathieu, HUE, Christophe

“…Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated with overactivation of the alternative pathway of complement. Four…”
Get full text

Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes by McDonald, Lindsay, Cayla, Mathieu, Ivens, Alasdair, Mony, Binny M, MacGregor, Paula, Silvester, Eleanor, McWilliam, Kirsty, Matthews, Keith R

“…Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in the mammalian bloodstream to prepare for transmission…”
Get full text

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome by Roumenina, Lubka T., Jablonski, Mathieu, Hue, Christophe, Blouin, Jacques, Dimitrov, Jordan D., Dragon-Durey, Marie-Agnes, Cayla, Mathieu, Fridman, Wolf H., Macher, Marie-Alice, Ribes, David, Moulonguet, Luc, Rostaing, Lionel, Satchell, Simon C., Mathieson, Peter W., Sautes-Fridman, Catherine, Loirat, Chantal, Regnier, Catherine H., Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique

“…Complement is a major innate immune defense against pathogens, tightly regulated to prevent host tissue damage. Atypical hemolytic uremic syndrome (aHUS) is…”
Get full text

Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability by Cayla, Mathieu, Rachidi, Najma, Leclercq, Olivier, Schmidt-Arras, Dirk, Rosenqvist, Heidi, Wiese, Martin, Späth, Gerald F

“…Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage…”
Get full text

A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation by Cayla, Mathieu, Matthews, Keith R, Ivens, Alasdair C

“…Low-complexity regions (LCRs) on proteins have attracted increasing attention recently due to their role in the assembly of membraneless organelles or granules…”
Get full text

Gel-Based Methods for the Investigation of Signal Transduction Pathways in Trypanosoma brucei by Szöőr, Balázs, Cayla, Mathieu

“…In the cell, reversible phosphorylation, controlled by protein phosphatases and protein kinases, initiates and regulates various signaling-dependent processes…”
Get more information

Distinguishing functions of trypanosomatid protein kinases by Cayla, Mathieu, Nievas, Y. Romina, Matthews, Keith R., Mottram, Jeremy C.

“…Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt…”
Get full text

A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation by Cayla, Mathieu, Matthews, Keith R., Ivens, Alasdair C.

“…Background: Low-complexity regions (LCRs) on proteins have attracted increasing attention recently due to their role in the assembly of membraneless organelles…”
Get full text

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses by Dacher, Mariko, Morales, Miguel A., Pescher, Pascale, Leclercq, Olivier, Rachidi, Najma, Prina, Eric, Cayla, Mathieu, Descoteaux, Albert, Späth, Gerald F.

“…Summary Leishmania parasites cause important human morbidity and mortality. Essential Leishmania genes escape genetic assessment by loss‐of‐function analyses…”
Get full text

Probing druggability and biological function of essential proteins in L eishmania combining facilitated null mutant and plasmid shuffle analyses by Dacher, Mariko, Morales, Miguel A., Pescher, Pascale, Leclercq, Olivier, Rachidi, Najma, Prina, Eric, Cayla, Mathieu, Descoteaux, Albert, Späth, Gerald F.

“…L eishmania parasites cause important human morbidity and mortality. Essential L eishmania genes escape genetic assessment by loss‐of‐function analyses due to…”
Get full text

Transgenic Analysis of the Leishmania MAP Kinase MPK10 Reveals an Auto-inhibitory Mechanism Crucial for Stage-Regulated Activity and Parasite Viability: e1004347 by Cayla, Mathieu, Rachidi, Najma, Leclercq, Olivier, Schmidt-Arras, Dirk, Rosenqvist, Heidi, Wiese, Martin, Späth, Gerald F

“…Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage…”
Get full text

Large spectrum of Factor B aHUS mutations functional consequences on the C3 convertase – From gain to lack of functional consequence by Roumenina, Lubka T, Vergoz, Laura, Rybkine, Tania, Donadelli, Roberta, Cayla, Mathieu, Smith, Richard, Noris, Marina, Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique

Get full text

Further evidence for a paradoxical role of the alternative pathway C3 convertase in atypical haemolytic Uremic Syndrome by Roumenina, Lubka, Cayla, Mathieu, Hue, Christophe, Bigot, Sylvain, Satchell, Simon, Mathieson, Peter, Loirat, Chantal, Sautes-Fridman, Catherine, Dragon-Durey, Marie-Agnes, Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique

Get full text