Search Results - "CAWTHORNE, MICHAEL A"

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids by Zaibi, Mohamed S., Stocker, Claire J., O’Dowd, Jacqueline, Davies, Alison, Bellahcene, Mohamed, Cawthorne, Michael A., Brown, Alastair J.H., Smith, David M., Arch, Jonathan R.S.

“…GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating Gαi. Here, we agree…”
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Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet by Stolarczyk, Emilie, Vong, Chi Teng, Perucha, Esperanza, Jackson, Ian, Cawthorne, Michael A., Wargent, Edward T., Powell, Nick, Canavan, James B., Lord, Graham M., Howard, Jane K.

“…Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient in the immune cell…”
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A novel method to assess collagen architecture in skin by Osman, Osman S, Selway, Joanne L, Harikumar, Parvathy E, Stocker, Claire J, Wargent, Edward T, Cawthorne, Michael A, Jassim, Sabah, Langlands, Kenneth

“…Texture within biological specimens may reveal critical insights, while being very difficult to quantify. This is a particular problem in histological…”
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5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats by Martin-Gronert, Malgorzata S, Stocker, Claire J, Wargent, Edward T, Cripps, Roselle L, Garfield, Alastair S, Jovanovic, Zorica, D'Agostino, Giuseppe, Yeo, Giles S H, Cawthorne, Michael A, Arch, Jonathan R S, Heisler, Lora K, Ozanne, Susan E

“…Although obesity is a global epidemic, the physiological mechanisms involved are not well understood. Recent advances reveal that susceptibility to obesity can…”
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Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes by Christiansen, Elisabeth, Hansen, Steffen V. F, Urban, Christian, Hudson, Brian D, Wargent, Edward T, Grundmann, Manuel, Jenkins, Laura, Zaibi, Mohamed, Stocker, Claire J, Ullrich, Susanne, Kostenis, Evi, Kassack, Matthias U, Milligan, Graeme, Cawthorne, Michael A, Ulven, Trond

“…Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new…”
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Fetal origins of insulin resistance and obesity by Stocker, Claire J., Arch, Jonathan R. S., Cawthorne, Michael A.

“…A number of epidemiological studies worldwide have demonstrated a relationship between poor early growth and an increased susceptibility to insulin resistance,…”
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Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion by EMILSSON, V, LIU, Y.-L, CAWTHORNE, M. A, MORTON, N. M, DAVENPORT, M

“…Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and…”
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Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes by Wargent, Edward T, Zaibi, Mohamed S, O'Dowd, Jacqueline F, Cawthorne, Michael A, Wang, Steven J, Arch, Jonathan R S, Stocker, Claire J

“…The literature is unclear on whether the adipokine chemerin has pro- or anti-inflammatory properties or plays any role in the aetiology of type 2 diabetes or…”
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Dual acting and pan-PPAR activators as potential anti-diabetic therapies by Heald, Monique, Cawthorne, Michael A

“…The thiazolidinedione PPAR-γ activator drugs rosiglitazone and pioglitazone suppress insulin resistance in type 2 diabetic patients. They lock lipids into…”
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Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3 by Ngala, Robert A, Zaibi, Mohamed S, Langlands, Kenneth, Stocker, Claire J, Arch, Jonathan R S, Cawthorne, Michael A

“…Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3(-/-) mice are protected from diet-induced insulin resistance and…”
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Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases by Christiansen, Elisabeth, Watterson, Kenneth R., Stocker, Claire J., Sokol, Elena, Jenkins, Laura, Simon, Katharina, Grundmann, Manuel, Petersen, Rasmus K., Wargent, Edward T., Hudson, Brian D., Kostenis, Evi, Ejsing, Christer S., Cawthorne, Michael A., Milligan, Graeme, Ulven, Trond

“…Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mechanisms of action are…”
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Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ ob mice by Haynes, Andrea C, Chapman, Helen, Taylor, Colleen, Moore, Gary B.T, Cawthorne, Michael A, Tadayyon, Mohammad, Clapham, John C, Arch, Jonathan R.S

“…A single dose of the orexin-1 (OX 1) receptor antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1,5] naphthyridin-4-yl urea hydrochloride (SB-334867-A) reduces…”
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Inhibition of Insulin Secretion by Betagranin, an N-terminal Chromogranin A Fragment by Schmid, Gerhard M., Meda, Paolo, Caille, Dorothée, Wargent, Ed, O'Dowd, Jacqueline, Hochstrasser, Denis F., Cawthorne, Michael A., Sanchez, Jean-Charles

“…Betagranin, an N-terminal fragment of chromogranin A, results from a proteolytic processing, and is co-secreted with insulin. While other chromogranin…”
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Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content by Bellahcene, Mohamed, O'Dowd, Jacqueline F., Wargent, Ed T., Zaibi, Mohamed S., Hislop, David C., Ngala, Robert A., Smith, David M., Cawthorne, Michael A., Stocker, Claire J., Arch, Jonathan R. S.

“…SCFA are produced in the gut by bacterial fermentation of undigested carbohydrates. Activation of the Gαi-protein-coupled receptor GPR41 by SCFA in β-cells and…”
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Effect of Rosiglitazone on the Differential Expression of Diabetes-associated Proteins in Pancreatic Islets of C57Bl/6 lep/lep Mice by Sanchez, Jean-Charles, Converset, Véronique, Nolan, Anna, Schmid, Gerhard, Wang, Steven, Heller, Manfred, Sennitt, Matthew V, Hochstrasser, Denis F, Cawthorne, Michael A

“…The insulin sensitizer drug, rosiglitazone, has been shown to have a protective effect on pancreatic islet cell structure and function in animal models of type…”
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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function by Yavari, Arash, Stocker, Claire J., Ghaffari, Sahar, Wargent, Edward T., Steeples, Violetta, Czibik, Gabor, Pinter, Katalin, Bellahcene, Mohamed, Woods, Angela, Martínez de Morentin, Pablo B., Cansell, Céline, Lam, Brian Y.H., Chuster, André, Petkevicius, Kasparas, Nguyen-Tu, Marie-Sophie, Martinez-Sanchez, Aida, Pullen, Timothy J., Oliver, Peter L., Stockenhuber, Alexander, Nguyen, Chinh, Lazdam, Merzaka, O’Dowd, Jacqueline F., Harikumar, Parvathy, Tóth, Mónika, Beall, Craig, Kyriakou, Theodosios, Parnis, Julia, Sarma, Dhruv, Katritsis, George, Wortmann, Diana D.J., Harper, Andrew R., Brown, Laurence A., Willows, Robin, Gandra, Silvia, Poncio, Victor, de Oliveira Figueiredo, Márcio J., Qi, Nathan R., Peirson, Stuart N., McCrimmon, Rory J., Gereben, Balázs, Tretter, László, Fekete, Csaba, Redwood, Charles, Yeo, Giles S.H., Heisler, Lora K., Rutter, Guy A., Smith, Mark A., Withers, Dominic J., Carling, David, Sternick, Eduardo B., Arch, Jonathan R.S., Cawthorne, Michael A., Watkins, Hugh, Ashrafian, Houman

“…Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge…”
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Chemerin, a Novel Adipokine in the Regulation of Angiogenesis by Bozaoglu, Kiymet, Curran, Joanne E., Stocker, Claire J., Zaibi, Mohamed S., Segal, David, Konstantopoulos, Nicky, Morrison, Shona, Carless, Melanie, Dyer, Thomas D., Cole, Shelley A., Goring, Harald H. H., Moses, Eric K., Walder, Ken, Cawthorne, Michael A., Blangero, John, Jowett, Jeremy B. M.

“…Context: Chemerin is a new adipokine associated with obesity and the metabolic syndrome. Gene expression levels of chemerin were elevated in the adipose depots…”
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Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice by Sanchez, Jean-Charles, Converset, Véronique, Nolan, Anna, Schmid, Gerhard, Wang, Steven, Heller, Manfred, Sennitt, Matthew V., Hochstrasser, Denis F., Cawthorne, Michael A.

“…Peroxisome proliferator‐activated receptors (PPARs) participate in the molecular mechanism of pathologies with altered lipid homeostasis such as type 2…”
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Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model by Harzallah, Arij, Hammami, Mohamed, Kępczyńska, Malgorzata A., Hislop, David C., Arch, Jonathan R. S., Cawthorne, Michael A., Zaibi, Mohamed S.

“…Objective: The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on…”
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Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation by Wargent, Ed, Sennitt, Matthew V, Stocker, Claire, Mayes, Andrew E, Brown, Louise, O'Dowd, Jacqueline, Wang, Steven, Einerhand, Alexandra W C, Mohede, Inge, Arch, Jonathan R S, Cawthorne, Michael A

“…Studies in rodents and some studies in humans have shown that conjugated linoleic acid (CLA), especially its trans-10, cis-12 isomer, reduces body fat content…”
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