Search Results - "CAWSTON, TIM E."

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases by Hui, Wang, Litherland, Gary J, Elias, Martina S, Kitson, Gareth I, Cawston, Tim E, Rowan, Andrew D, Young, David A

“…To investigate the effect of leptin on cartilage destruction. Collagen release was assessed in bovine cartilage explant cultures, while collagenolytic and…”
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Activity of matrix metalloproteinase‐9 against native collagen types I and III by Bigg, Heather F., Rowan, Andrew D., Barker, Michael D., Cawston, Tim E.

“…Interstitial collagen types I, II and III are highly resistant to proteolytic attack, due to their triple helical structure, but can be cleaved by matrix…”
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The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation by Bigg, Heather F., Wait, Robin, Rowan, Andrew D., Cawston, Tim E.

“…YKL-40 is expressed in arthritic cartilage and produced in large amounts by cultured chondrocytes, but its exact role is unclear, and the identities of its…”
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Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation by Barter, Matt J, Hui, Wang, Lakey, Rachel L, Catterall, John B, Cawston, Tim E, Young, David A

“…To investigate if statins prevent cartilage degradation and the production of collagenases and gelatinases in bovine nasal and human articular cartilage after…”
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Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent by Litherland, Gary J., Dixon, Craig, Lakey, Rachel L., Robson, Timothy, Jones, Debra, Young, David A., Cawston, Tim E., Rowan, Andrew D.

“…The phosphatidylinositol 3-kinase (PI3K) signaling pathway has emerged as a major regulator of cellular functions and has been implicated in several…”
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Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage by Hui, Wang, Young, David A, Rowan, Andrew D, Xu, Xin, Cawston, Tim E, Proctor, Carole J

“…To use a computational approach to investigate the cellular and extracellular matrix changes that occur with age in the knee joints of mice. Knee joints from…”
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Proteinases involved in matrix turnover during cartilage and bone breakdown by Cawston, Tim E., Young, David A.

“…The joint is a discrete unit that consists of cartilage, bone, tendon and ligaments. These tissues are all composed of an extracellular matrix made of…”
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Understanding the role of tissue degrading enzymes and their inhibitors in development and disease by Cawston, Tim E., Wilson, Amy J.

“…Cartilage and the underlying bone are destroyed in severe cases of arthritis preventing joints from functioning normally. Cartilage and bone collagen can be…”
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HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes by Barter, Matt J., Pybus, Leon, Litherland, Gary J., Rowan, Andrew D., Clark, Ian M., Edwards, Dylan R., Cawston, Tim E., Young, David A.

“…Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for…”
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Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate by Cawston, Tim E

“…This protocol describes how to purify and radiolabel collagen for use as a substrate to assay collagenolytic members of the matrix metalloproteinases (MMPs)…”
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Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway by Hui, Wang, Litherland, Gary J., Jefferson, Matthew, Barter, Matt J., Elias, Martina S., Cawston, Tim E., Rowan, Andrew D., Young, David A.

“…Objectives. To determine the effects and mechanism of action of lithium chloride (LiCl) on cartilage destruction induced by the pro-inflammatory cytokines…”
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Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis by Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A

“…Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the…”
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Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases by Lakey, Rachel L., Cawston, Tim E.

“…Objective. To investigate the effect of SSZ on the release of GAG and collagen fragments from bovine nasal cartilage and MMP and ADAMTS (a disintegrin and…”
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Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper by Kloppenburg, Margreet, Stamm, Tanja, Watt, Iain, Kainberger, Franz, Cawston, Tim E, Birrell, Fraser N, Petersson, Ingemar F, Saxne, Tore, Kvien, Tore K, Slatkowsky-Christensen, Barbara, Dougados, Maxime, Gossec, Laure, Breedveld, Ferdinand C, Smolen, Josef S

“…Background: Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients’ lives, but knowledge and research…”
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In vitro model of cartilage degradation by Hui, Wang, Cawston, Tim E

“…This 14-day model of cartilage breakdown involves stimulation of bovine nasal cartilage with a combination of interleukin-1 and oncostatin M. Media is…”
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Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model by Rowan, Andrew D., Hui, Wang, Cawston, Tim E., Richards, Carl D.

“…Oncostatin M (OSM) is an interleukin (IL)-6 family cytokine that we have previously shown can synergize with a number of proinflammatory cytokines to promote…”
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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis by Milner, Jennifer M., Patel, Amit, Davidson, Rose K., Swingler, Tracey E., Desilets, Antoine, Young, David A., Kelso, Elizabeth B., Donell, Simon T., Cawston, Tim E., Clark, Ian M., Ferrell, William R., Plevin, Robin, Lockhart, John C., Leduc, Richard, Rowan, Andrew D.

“…Objective Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane…”
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A novel paradigm for dendritic cells as effectors of cartilage destruction by Lakey, Rachel L., Morgan, Tanya G., Rowan, Andrew D., Isaacs, John D., Cawston, Tim E., Hilkens, Catharien M. U.

“…Objective. Dendritic cells (DCs) are enriched in RA synovium and have been implicated in the pathogenesis of RA primarily through their ability to present…”
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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL by Hui, Wang, Cawston, Tim E, Richards, Carl D, Rowan, Andrew D

“…Oncostatin M is a pro-inflammatory cytokine previously shown to promote marked cartilage destruction both in vitro and in vivo when in combination with IL-1 or…”
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Assay of matrix metalloproteinases against matrix substrates by Cawston, Tim E, Lakey, Rachel L, Rowan, Andrew D

“…The assays described allow the activity of members of the matrix metalloproteinase (MMP) family that degrade collagen, gelatin and casein substrates to be…”
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