Search Results - "CAVANAGH, David R"

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY by Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Sharman, Joanna L, Campo, Brice, Cavanagh, David R, Alexander, Stephen P H, Davenport, Anthony P, Spedding, Michael, Davies, Jamie A

“…Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between…”
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α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes by Stevenson, Liz, Laursen, Erik, Cowan, Graeme J, Bandoh, Betty, Barfod, Lea, Cavanagh, David R, Andersen, Gregers R, Hviid, Lars

“…Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P…”
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Breadth and Magnitude of Antibody Responses to Multiple Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Clinical Malaria by Osier, Faith H.A, Fegan, Gregory, Polley, Spencer D, Murungi, Linda, Verra, Federica, Tetteh, Kevin K.A, Lowe, Brett, Mwangi, Tabitha, Bull, Peter C, Thomas, Alan W, Cavanagh, David R, McBride, Jana S, Lanar, David E, Mackinnon, Margaret J, Conway, David J, Marsh, Kevin

“…Individuals living in areas where malaria is endemic are repeatedly exposed to many different malaria parasite antigens. Studies on naturally acquired…”
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Plasmodium falciparum 19-Kilodalton Merozoite Surface Protein 1 (MSP1)-Specific Antibodies That Interfere with Parasite Growth In Vitro Can Inhibit MSP1 Processing, Merozoite Invasion, and Intracellular Parasite Development by MOSS, David K, REMARQUE, Edmond J, FABER, Bart W, CAVANAGH, David R, ARNOT, David E, THOMAS, Alan W, HOLDER, Anthony A

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A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila by Cowan, Graeme J M, Bockau, Ulrike, Eleni-Muus, Janna, Aldag, Ingo, Samuel, Kay, Creasey, Alison M, Hartmann, Marcus W W, Cavanagh, David R

“…Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components. We have…”
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Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery–Dreifuss muscular dystrophy by Meinke, Peter, Schneiderat, Peter, Srsen, Vlastimil, Korfali, Nadia, Lê Thành, Phú, Cowan, Graeme J.M, Cavanagh, David R, Wehnert, Manfred, Schirmer, Eric C, Walter, Maggie C

“…Highlights • X-linked female presenting with EDMD1 not explained by uneven X-inactivation. • First EDMD blood phenotype with highly lobulated lymphocytes in…”
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Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso by Cherif, Mariama K, Ouédraogo, Oumarou, Sanou, Guillaume S, Diarra, Amidou, Ouédraogo, Alphonse, Tiono, Alfred, Cavanagh, David R, Michael, Theisen, Konaté, Amadou T, Watson, Nora L, Sanza, Megan, Dube, Tina J T, Sirima, Sodiomon B, Nebié, Issa

“…High parasite-specific antibody levels are generally associated with low susceptibility to Plasmodium falciparum malaria. This has been supported by several…”
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A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response by Cowan, Graeme J M, Creasey, Alison M, Dhanasarnsombut, Kelwalin, Thomas, Alan W, Remarque, Edmond J, Cavanagh, David R

“…Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A…”
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Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys by Cavanagh, David R, Kocken, Clemens H M, White, John H, Cowan, Graeme J M, Samuel, Kay, Dubbeld, Martin A, Voorberg-van der Wel, Annemarie, Thomas, Alan W, McBride, Jana S, Arnot, David E

“…The Block 2 region of the merozoite surface protein-1 (MSP-1) of Plasmodium falciparum has been identified as a target of protective immunity by a combination…”
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Antibodies to the N-Terminal Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Associated with Protection against Clinical Malaria by CAVANAGH, David R, DODOO, Daniel, HVIID, Lars, KURTZHALS, Jørgen A. L, THEANDER, Thor G, AKANMORI, Bartholomew D, POLLEY, Spencer, CONWAY, David J, KORAM, Kojo, MCBRIDE, Jana S

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Diversity Covering AMA1-MSP119 Fusion Proteins as Malaria Vaccines by Faber, Bart W, Younis, Sumera, Remarque, Edmond J, Rodriguez Garcia, Roberto, Riasat, Vanessa, Walraven, Vanessa, van der Werff, Nicole, van der Eijk, Marjolein, Cavanagh, David R, Holder, Anthony A, Thomas, Alan W, Kocken, Clemens H M

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Comparative Testing of Six Antigen-Based Malaria Vaccine Candidates Directed Toward Merozoite-Stage Plasmodium falciparum by Arnot, David E, Cavanagh, David R, Remarque, Edmond J, Creasey, Alison M, Sowa, Mercy P K, Morgan, William D, Holder, Anthony A, Longacre, Shirley, Thomas, Alan W

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Differential Antibody Responses to Plasmodium falciparum Merozoite Proteins in Malawian Children with Severe Malaria by Dobaño, Carlota, Rogerson, Stephen J., Mackinnon, Margaret J., Cavanagh, David R., Taylor, Terrie E., Molyneux, Malcolm E., McBride, Jana S.

“…Cerebral malaria (CM) and severe malarial anemia (SMA) are 2 major causes of death in African children infected with Plasmodium falciparum. We investigated…”
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Immunological Consequences of Antihelminthic Treatment in Preschool Children Exposed to Urogenital Schistosome Infection by Rujeni, Nadine, Nausch, Norman, Midzi, Nicholas, Cowan, Graeme J., Burchmore, Richard, Cavanagh, David R., Taylor, David W., Mduluza, Takafira, Mutapi, Francisca

“…Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool…”
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Seroepidemiology of Plasmodium species infections in Zimbabwean population by Amanfo, Seth A, Mduluza, Takafira, Midzi, Nicholas, Cavanagh, David R, Mutapi, Francisca

“…Individuals living in malaria-endemic regions may be exposed to more than one Plasmodium species; there is paucity of data on the distribution of the different…”
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Repeat Sequences in Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria by POLLEY, Spencer D, TETTEH, Kevin K. A, CAVANAGH, David R, PEARCE, Richard J, LLOYD, Jennifer M, BOJANG, Kalifa A, OKENU, Daniel M. N, GREENWOOD, Brian M, MCBRIDE, Jana S, CONWAY, David J

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Extensive Antigenic Polymorphism within the Repeat Sequence of the Plasmodium falciparum Merozoite Surface Protein 1 Block 2 Is Incorporated in a Minimal Polyvalent Immunogen by TETTEH, Kevin K. A, CAVANAGH, David R, CORRAN, Patrick, MUSONDA, Rosemary, MCBRIDE, Jana S, CONWAY, David J

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Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas by Adu, Bright, Cherif, Mariama K, Bosomprah, Samuel, Diarra, Amidou, Arthur, Fareed K N, Dickson, Emmanuel K, Corradin, Giampietro, Cavanagh, David R, Theisen, Michael, Sirima, Sodiomon B, Nebie, Issa, Dodoo, Daniel

“…Differences in parasite transmission intensity influence the process of acquisition of host immunity to Plasmodium falciparum malaria and ultimately, the rate…”
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Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum by CAVANAGH, David R, DOBANO, Carlota, ELHASSAN, Ibrahim M, MARSH, Kevin, ELHASSAN, Ahmed, HVIID, Lars, KHALIL, E. At Tahir G, THEANDER, Thor G, ARNOT, David E, MCBRIDE, Jana S

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Antibody Responses to Plasmodium falciparum Merozoite Surface Protein–1 and Efficacy of Amodiaquine in Gabonese Children with P. falciparum Malaria by Mawili-Mboumba, Denise P, Borrmann, Steffen, Cavanagh, David R, McBride, Jana S, Matsiegui, Pierre-Blaise, Missinou, Michel A, Kremsner, Peter G, Ntoumi, Francine

“…The relationship between the efficacy of amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria and preexisting antibodies against…”
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