Search Results - "CATTLEY, R. C"

Disruption of Androgen-Regulated Male Reproductive Development by Di(n-Butyl) Phthalate during Late Gestation in Rats Is Different from Flutamide by Mylchreest, Eve, Sar, Madhabananda, Cattley, Russell C., Foster, Paul M.D.

“…Gestational and lactational exposure to di(n-butyl) phthalate (DBP) at ≥250 mg/kg/day disrupts male rat reproductive development and function. Although this…”
Get full text

Male Reproductive Tract Malformations in Rats Following Gestational and Lactational Exposure to Di(n-butyl) Phthalate: An Antiandrogenic Mechanism? by Mylchreest, Eve, Cattley, Russell C., Foster, Paul M.D.

“…Di(n-butyl) phthalate (DBP), a widely used plasticizer suspected of having estrogenic properties, was investigated for its effects on the prenatal and early…”
Get full text

Effects of di- n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment by Foster, P.M.D, Cattley, R.C, Mylchreest, E

“…The National Toxicology Program (NTP) conducted a continuous breeding study in SD rats with di- n-butyl phthalate (DBP) given via the diet at dose levels of up…”
Get full text

Role of PPARα in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643 by PETERS, J. M, CATTLEY, R. C, GONZALEZ, F. J

“…Chronic administration of peroxisome proliferators to mice and rats results in hepatomegaly and ultimately carcinogenesis. The mechanism underlying the…”
Get full text

Pubertal development and reproductive functions of Crl:CD BR Sprague-Dawley rats exposed to bisphenol A during prenatal and postnatal development by KWON, S, STEDMAN, D. B, ELSWICK, B. A, CATTLEY, R. C, WELSCH, F

“…Bisphenol A (BPA) is used on a large scale in the manufacture of polycarbonate plastics. BPA has been shown to bind weakly to both estrogen receptor (ER)alpha…”
Get full text

IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice by Faggioni, Raffaella, Cattley, Russell C, Guo, Jane, Flores, Silvia, Brown, Heather, Qi, Meiying, Yin, Songmei, Hill, David, Scully, Sheila, Chen, Ching, Brankow, David, Lewis, Jeffrey, Baikalov, Claudia, Yamane, Harvey, Meng, Tina, Martin, Frank, Hu, Sylvia, Boone, Tom, Senaldi, Giorgio

“…IL-18-binding protein (IL-18BP) is a natural IL-18 inhibitor. Human IL-18BP isoform a was produced as fusion construct with human IgG1 Fc and assessed for…”
Get full text

Role of peroxisome proliferator-activated receptor α in altered cell cycle regulation in mouse liver by PETERS, J. M, AOYAMA, T, CATTLEY, R. C, NOBUMITSU, U, HASHIMOTO, T, GONZALEZ, F. J

“…The mechanisms underlying peroxisome proliferator-induced hepatocarcinogenesis are unclear but are mediated by the peroxisome proliferator-activated receptor…”
Get full text

Autopsy by Cattley, R. C.

Get full text

Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans? by Cattley, Russell C., DeLuca, John, Elcombe, Cliff, Fenner-Crisp, Penelope, Lake, Brian G., Marsman, Daniel S., Pastoor, Timothy A., Popp, James A., Robinson, Denise E., Schwetz, Bernard, Tugwood, Jonathan, Wahli, Walter

“…The purpose of the workshop “Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?” was to provide a review of the current state of…”
Get full text

Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha by Fan, LQ, Cattley, RC, Corton, JC

“…The 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) family of proteins regulates the levels of the active 17 beta-hydroxy forms of sex steroids. The…”
Get full text

Interactive effects of dietary adaptation period length and titration diet type on apparent ileal phosphorus digestibility and phosphorus retention in growing broilers by Perryman, K R, Cattley, R C, Masey O'Neill, H V, Bedford, M R, Dozier, 3rd, W A

“…Two experiments were conducted to examine the effects of different corn titration diets and dietary adaptation period length (DAPL) on intestinal histology,…”
Get full text

Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on Fischer-344 rats and CD-1 mice by MEDINSKY, M. A, WOLF, D. C, CATTLEY, R. C, WONG, B, JANSZEN, D. B, FARRIS, G. M, WRIGHT, G. A, BOND, J. A

“…The 1990 Clean Air Act Amendments require that oxygenates be added to automotive fuels to reduce emissions of carbon monoxide and hydrocarbons. One potential…”
Get full text

Experimental Transmission of Corynebacterium pseudotuberculosis Biovar equi in Horses by House Flies by Barba, M., Stewart, A.J., Passler, T., Wooldridge, A.A., Santen, E., Chamorro, M.F., Cattley, R.C., Hathcock, T., Hogsette, J.A., Hu, X.P.

“…Background The route of Corynebacterium pseudotuberculosis infection in horses remains undetermined, but transmission by insects is suspected. Objectives To…”
Get full text

Manganese-induced developmental neurotoxicity in the CD rat: is oxidative damage a mechanism of action? by Brenneman, K A, Cattley, R C, Ali, S F, Dorman, D C

“…Inhalation of high concentrations of manganese (Mn) is associated with an extrapyramidal motor disorder in humans. Oxidative damage, mediated by increased…”
Get more information

Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor by Gonzalez, F. J., Peters, J. M., Cattley, R. C.

“…Peroxisome proliferators are a diverse group of chemicals that include several therapeutically used drugs (e.g., hypolipidemic agents), plasticizers and…”
Get full text

Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators by Rose, Michelle L., Rivera, Chantal A., Bradford, Blair U., Graves, Lee M., Cattley, Russell C., Schoonhoven, Robert, Swenberg, James A., Thurman, Ronald G.

“…Increased cell proliferation most likely plays a key role in peroxisome proliferator-induced liver cancer. Recently, Kupffer cells were shown to be responsible…”
Get full text

Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643 by Rose, Michelle L., Cattley, Russell C., Dunn, Corrie, Wong, Victoria, Li, Xiang, Thurman, Ronald G.

“…Previous studies demonstrated that dietary glycine prevents elevated rates of cell proliferation following treatment with the peroxisome proliferator and liver…”
Get full text

Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators by RUSYN, Ivan, YAMASHINA, Shunhei, SEGAL, Brahm H, SCHOONHOVEN, Robert, HOLLAND, Steven M, CATTLEY, Russell C, SWENBERG, James A, THURMAN, Ronald G

“…It was shown that 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (Wy-14,643), a potent peroxisome proliferator, caused rapid oxidant-dependent…”
Get full text

Alterations in Endocrine Responses in Male Sprague-Dawley Rats following Oral Administration of Methyl tert-Butyl Ether by Williams, Tracy M., Cattley, Russell C., Borghoff, Susan J.

“…Methyl tert-butyl ether (MTBE) is an oxygenated fuel additive used to decrease carbon monoxide emissions during combustion. MTBE is a nongenotoxic chemical…”
Get full text

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators Di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats by MARSMAN, D. S, CATTLEY, R. C, CONWAY, J. G, POPP, J. A

“…The mechanism of hepatocarcinogenesis caused by peroxisome proliferators (PP) is poorly understood, making it difficult to predict the carcinogenicity of PP to…”
Get full text