Search Results - "CATLEY, Matthew"

P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke by Eltom, Suffwan, Stevenson, Christopher S, Rastrick, Joseph, Dale, Nicole, Raemdonck, Kristof, Wong, Sissie, Catley, Matthew C, Belvisi, Maria G, Birrell, Mark A

“…Chronic Obstructive Pulmonary Disease (COPD) is a cigarette smoke (CS)-driven inflammatory airway disease with an increasing global prevalence. Currently there…”
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Monoclonal antibodies for the treatment of asthma by Catley, Matthew C, Coote, Julie, Bari, Mohamed, Tomlinson, Kate L

“…Asthma is a chronic inflammatory disease of the airways which can have a detrimental effect on quality of life and in extreme cases cause death. Although the…”
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Patient stratification and the unmet need in asthma by Swedin, Linda, Saarne, Tiiu, Rehnberg, Maria, Glader, Pernilla, Niedzielska, Magdalena, Johansson, Gustav, Hazon, Petra, Catley, Matthew C

“…Asthma is often described as an inflammatory disease of the lungs and in most patients symptomatic treatment with bronchodilators or inhaled corticosteroids is…”
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Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration by Smith, Bryan, Kiessling, Andrea, Lledo-Garcia, Rocio, Dixon, Kate L, Christodoulou, Louis, Catley, Matthew C, Atherfold, Paul, D'Hooghe, Lena E, Finney, Helene, Greenslade, Kevin, Hailu, Hanna, Kevorkian, Lara, Lightwood, Daniel, Meier, Christoph, Munro, Rebecca, Qureshi, Omar, Sarkar, Kaushik, Shaw, Sophie P, Tewari, Roohi, Turner, Alison, Tyson, Kerry, West, Shauna, Shaw, Stevan, Brennan, Frank R

“…Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce…”
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Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages by Birrell, Mark A., Wong, Sissie, Catley, Matthew C., Belvisi, Maria G.

“…Many of the healthcare consequences of cigarette smoking could be due to its ability to compromise the immune system, and in respiratory diseases like chronic…”
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OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans by Burrows, Katie E., Dumont, Celine, Thompson, Clare L., Catley, Matthew C., Dixon, Kate L., Marshall, Diane

“…The costimulatory receptor OX40 is expressed on activated T cells and regulates T‐cell responses. Here, we show the efficacy and mechanism of action of an OX40…”
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Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum by Ravi, Arjun K, Khurana, Shruti, Lemon, Jonathan, Plumb, Jonathan, Booth, George, Healy, Louise, Catley, Matthew, Vestbo, Jørgen, Singh, Dave

“…COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs…”
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COPD monocytes demonstrate impaired migratory ability by Ravi, Arjun K, Plumb, Jonathan, Gaskell, Rosemary, Mason, Sarah, Broome, Caroline S, Booth, George, Catley, Matthew, Vestbo, Jørgen, Singh, Dave

“…Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor…”
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Cigarette smoke induced airway inflammation is independent of NF-κB signalling by Rastrick, Joseph M D, Stevenson, Christopher S, Eltom, Suffwan, Grace, Megan, Davies, Meirion, Kilty, Iain, Evans, Steven M, Pasparakis, Manolis, Catley, Matthew C, Lawrence, Toby, Adcock, Ian M, Belvisi, Maria G, Birrell, Mark A

“…COPD is an inflammatory lung disease largely associated with exposure to cigarette smoke (CS). The mechanism by which CS leads to the pathogenesis of COPD is…”
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Novel Role for the Liver X Nuclear Receptor in the Suppression of Lung Inflammatory Responses by Birrell, Mark A., Catley, Matthew C., Hardaker, Elizabeth, Wong, Sissie, Willson, Timothy M., McCluskie, Kerryn, Leonard, Thomas, Farrow, Stuart N., Collins, Jon L., Haj-Yahia, Saleem, Belvisi, Maria G.

“…The liver X receptors (LXRα/β) are part of the nuclear receptor family and are believed to regulate cholesterol and lipid homeostasis. It has also been…”
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Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE 2 inhibits the release of GM‐CSF by Clarke, Deborah L, Belvisi, Maria G, Catley, Matthew C, Yacoub, Magdi H, Newton, Robert, Giembycz, Mark A

“…The prostanoid receptor(s) on human airways smooth muscle (HASM) cells that mediates the inhibitory effect of PGE 2 on interleukin (IL)‐1 β ‐induced…”
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Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling by Rastrick, Joseph M. D., Stevenson, Christopher S., Eltom, Suffwan, Grace, Megan, Davies, Meirion, Kilty, Iain, Evans, Steven M., Pasparakis, Manolis, Catley, Matthew C., Lawrence, Toby, Adcock, Ian M., Belvisi, Maria G., Birrell, Mark A.

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Dissociated steroids by Catley, Matthew

“…Glucocorticoids (GCs) are some of the most important drugs in clinical use today. They are mainly used to suppress disease-related inflammation and are widely…”
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The Role of IκB Kinase 2, but Not Activation of NF-κB, in the Release of CXCR3 Ligands from IFN-γ-Stimulated Human Bronchial Epithelial Cells by Tudhope, Susan J., Catley, Matthew C., Fenwick, Peter S., Russell, Richard E. K., Rumsey, William L., Newton, Robert, Barnes, Peter J., Donnelly, Louise E.

“…The severity of chronic obstructive pulmonary disease correlates with increased numbers of cytotoxic CD8+ T lymphocytes in the lung parenchyma. CD8+ T…”
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Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease by Catley, Matthew C, Birrell, Mark A, Hardaker, Elizabeth L, de Alba, Jorge, Farrow, Stuart, Haj-Yahia, Saleem, Belvisi, Maria G

“…Estrogen receptor (ER) beta agonists have been demonstrated to possess anti-inflammatory properties in inflammatory disease models. The objective of this study…”
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Liver X Receptor Agonists Increase Airway Reactivity in a Model of Asthma via Increasing Airway Smooth Muscle Growth by Birrell, Mark A, De Alba, Jorge, Catley, Matthew C, Hardaker, Elizabeth, Wong, Sissie, Collins, Michael, Clarke, Deborah L, Farrow, Stuart N, Willson, Timothy M, Collins, Jon L, Belvisi, Maria G

“…The liver X receptors (LXRalpha/beta) are orphan nuclear receptors that are expressed in a large number of cell types and have been shown to have…”
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Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release by Chivers, Joanna E., Cambridge, Lisa M., Catley, Matthew C., Mak, Judith C., Donnelly, Louise E., Barnes, Peter J., Newton, Robert

“…In A549 pulmonary cells, the dexamethasone‐ and budesonide‐dependent repression of interleukin‐1β‐induced prostaglandin E2 release was mimicked by the steroid…”
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Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug by Debacker, Alexandre J., Voutila, Jon, Catley, Matthew, Blakey, David, Habib, Nagy

“…Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the asialoglycoprotein receptor has…”
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Validation of IKKβ as therapeutic target in airway inflammatory disease by adenoviral‐mediated delivery of dominant‐negative IKKβ to pulmonary epithelial cells by Catley, Matthew C, Chivers, Joanna E, Holden, Neil S, Barnes, Peter J, Newton, Robert

“…1 Asthma is an inflammatory disease of the lungs and the transcription factor NF‐κB regulates the production of numerous inflammatory mediators that may have a…”
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Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways by Birrell, Mark A, Wong, Sissie, McCluskie, Kerryn, Catley, Matthew C, Hardaker, Elizabeth L, Haj-Yahia, Saleem, Belvisi, Maria G

“…The exact role of p38 mitogen-activated protein kinase (MAPK) in the expression of inflammatory cytokines is not clear; it may regulate transcriptionally,…”
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