Search Results - "CATALDO, ANNE M"

Alzheimer's-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition by Jiang, Ying, Mullaney, Kerry A, Peterhoff, Corrinne M, Che, Shaoli, Schmidt, Stephen D, Boyer-Boiteau, Anne, Ginsberg, Stephen D, Cataldo, Anne M, Mathews, Paul M, Nixon, Ralph A

“…An additional copy of the β-amyloid precursor protein (APP) gene causes early-onset Alzheimer's disease (AD) in trisomy 21 (DS). Endosome dysfunction develops…”
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Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression by Ginsberg, Stephen D, Alldred, Melissa J, Counts, Scott E, Cataldo, Anne M, Neve, Rachael L, Jiang, Ying, Wuu, Joanne, Chao, Moses V, Mufson, Elliott J, Nixon, Ralph A, Che, Shaoli

“…Background Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of…”
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Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease by Yang, Dun-Sheng, Kumar, Asok, Stavrides, Philip, Peterson, Jesse, Peterhoff, Corrine M, Pawlik, Monika, Levy, Efrat, Cataldo, Anne M, Nixon, Ralph A

“…Mechanisms of neuronal loss in Alzheimer's disease (AD) are poorly understood. Here we show that apoptosis is a major form of neuronal cell death in PS/APP…”
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Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression by Rao, Mala V, Mohan, Panaiyur S, Peterhoff, Corrinne M, Yang, Dun-Sheng, Schmidt, Stephen D, Stavrides, Philip H, Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A, Cataldo, Anne M, Haroutunian, Vahram, Nixon, Ralph A

“…Increased activity of calpains is implicated in synaptic dysfunction and neurodegeneration in Alzheimer's disease (AD). The molecular mechanisms responsible…”
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Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model by Choi, Jennifer H.K, Berger, Jason D, Mazzella, Matthew J, Morales-Corraliza, Jose, Cataldo, Anne M, Nixon, Ralph A, Ginsberg, Stephen D, Levy, Efrat, Mathews, Paul M

“…Individuals with Down syndrome develop β-amyloid deposition characteristic of early-onset Alzheimer's disease (AD) in mid-life, presumably because of an extra…”
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Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology by CATALDO, ANNE M, PETERHOFF, CORRINNE M, SCHMIDT, STEPHEN D, TERIO, NICOLE B, DUFF, KAREN, BEARD, MARGARET, MATHEWS, PAUL M, NIXON, RALPH A

“…The neuronal lysosomal system is a major degradative pathway, induced by cell stress and closely linked to Alzheimer disease (AD) and other neurodegenerative…”
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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons by Lie, Pearl P.Y., Yang, Dun-Sheng, Stavrides, Philip, Goulbourne, Chris N., Zheng, Ping, Mohan, Panaiyur S., Cataldo, Anne M., Nixon, Ralph A.

“…Lysosomal trafficking and maturation in neurons remain poorly understood and are unstudied in vivo despite high disease relevance. We generated neuron-specific…”
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Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease by Nixon, Ralph A, Cataldo, Anne M

“…The identification of cathepsins in amyloid-beta plaques revealed broad dysfunction of the lysosomal system in Alzheimer's disease (AD). Coinciding with the…”
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Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder by Cataldo, Anne M, McPhie, Donna L, Lange, Nicholas T, Punzell, Steven, Elmiligy, Sarah, Ye, Nancy Z, Froimowitz, Michael P, Hassinger, Linda C, Menesale, Emily B, Sargent, Laura W, Logan, David J, Carpenter, Anne E, Cohen, Bruce M

“…Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased mitochondrial activity as a factor in the manifestation of Bipolar…”
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Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system by Cataldo, Anne M, Barnett, Jody L, Berman, Stephen A, Li, Jinhe, Quarless, Shelley, Bursztajn, Sherry, Lippa, Carol, Nixon, Ralph A

“…In Alzheimer's disease brains, more than 90% of pyramidal neurons in lamina V and 70% in lamina III displayed 2- to 5-fold elevated levels of cathepsin D (Cat…”
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Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain : A Cautionary Report by Chartoff, Elena H., Damez-Werno, Diane, Sonntag, Kai C., Hassinger, Linda, Kaufmann, Daniel E., Peterson, Jesse, McPhie, Donna, Cataldo, Anne M., Cohen, Bruce M.

“…Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive…”
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Macroautophagy: A Novel β-Amyloid Peptide-Generating Pathway Activated in Alzheimer's Disease by Yu, W. Haung, Cuervo, Ana Maria, Kumar, Asok, Peterhoff, Corrinne M., Schmidt, Stephen D., Lee, Ju-Hyun, Mohan, Panaiyur S., Mercken, Marc, Farmery, Mark R., Tjernberg, Lars O., Jiang, Ying, Duff, Karen, Uchiyama, Yasuo, Näslund, Jan, Mathews, Paul M., Cataldo, Anne M., Nixon, Ralph A.

“…Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In…”
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Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology: Accelerated Endocytosis Promotes Late Endocytic Defects by Cataldo, Anne M, Mathews, Paul M, Boiteau, Anne Boyer, Hassinger, Linda C, Peterhoff, Corrinne M, Jiang, Ying, Mullaney, Kerry, Neve, Rachael L, Gruenberg, Jean, Nixon, Ralph A

“…Endocytic dysfunction is an early pathological change in Alzheimer's disease (AD) and Down's syndrome (DS). Using primary fibroblasts from DS individuals, we…”
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Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome by Cataldo, Anne M., Petanceska, Suzana, Terio, Nicole B., Peterhoff, Corrinne M., Durham, Robert, Mercken, Marc, Mehta, Pankaj D., Buxbaum, Joseph, Haroutunian, Vahram, Nixon, Ralph A.

“…Early endosomes are a major site of amyloid precursor protein (APP) processing and a convergence point for molecules of pathologic relevance to Alzheimer’s…”
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App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome by Cataldo, Anne M, Petanceska, Suzana, Peterhoff, Corrinne M, Terio, Nicole B, Epstein, Charles J, Villar, Angela, Carlson, Elaine J, Staufenbiel, Matthias, Nixon, Ralph A

“…Altered neuronal endocytosis is the earliest known pathology in sporadic Alzheimer's disease (AD) and Down syndrome (DS) brain and has been linked to increased…”
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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis : A review by NIXON, Ralph A, CATALDO, Anne M, MATHEWS, Paul M

“…A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the neuronal lysosomal system and major cellular pathways converging on…”
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Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis by Laifenfeld, Daphna, Patzek, Lucas J, McPhie, Donna L, Chen, Yuzhi, Levites, Yona, Cataldo, Anne M, Neve, Rachael L

“…Alzheimer's disease (AD) involves activation of apoptotic pathways that may be regulated through signaling cascades initiated by the amyloid precursor protein…”
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In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model by Chen, Yuanxin, Dyakin, Victor V, Branch, Craig A, Ardekani, Babak, Yang, Dunsheng, Guilfoyle, David N, Peterson, Jesse, Peterhoff, Corrinne, Ginsberg, Stephen D, Cataldo, Anne M, Nixon, Ralph A

“…Abstract In vivo quantitative magnetic resonance imaging (MRI) was employed to detect brain pathology and map its distribution within control, disomic mice…”
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Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer's Disease: Neuropathologic Evidence for a Mechanism of Increased beta -Amyloidogenesis by Cataldo, Anne M, Barnett, Jody L, Pieroni, Cristiana, Nixon, Ralph A

“…The early endosome is the first vacuolar compartment along the endocytic pathway. It is the site of internalization and initial processing of amyloid precursor…”
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The endosomal-lysosomal system of neurons: new roles by Nixon, Ralph A., Cataldo, Anne M.

“…The repertoire of the lysosomal system extends beyond its function in degrading biologic macromolecules for energy and recycling purposes. Controlled shifts in…”
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