Search Results - "CASTRO, Marian"

2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives by Areias, Filipe, Correia, Carla, Rocha, Ashly, Teixeira, Sofia, Castro, Marián, Brea, Jose, Hu, Huabin, Carlsson, Jens, Loza, Maria I, Proença, M Fernanda, Carvalho, M Alice

“…A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A , A , A , and A…”
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Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties by Mastromarino, Margherita, Niso, Mauro, Abate, Carmen, Proschak, Ewgenij, Dubiel, Mariam, Stark, Holger, Castro, Marián, Lacivita, Enza, Leopoldo, Marcello

“…Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we…”
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Sustained cyclic AMP production by parathyroid hormone receptor endocytosis by Ferrandon, Sébastien, Feinstein, Timothy N, Castro, Marian, Wang, Bin, Bouley, Richard, Potts, John T, Gardella, Thomas J, Vilardaga, Jean-Pierre

“…Cell signaling mediated by the G protein–coupled parathyroid hormone receptor type 1 (PTHR) is fundamental to bone and kidney physiology. It has been unclear…”
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Structure‐Based Virtual Screening for Dopamine D 2 Receptor Ligands as Potential Antipsychotics by Kaczor, Agnieszka A., Silva, Andrea G., Loza, María I., Kolb, Peter, Castro, Marián, Poso, Antti

“…Abstract Structure‐based virtual screening using a D 2 receptor homology model was performed to identify dopamine D 2 receptor ligands as potential…”
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Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons by Otero, Maria G, Bell, Shaughn, Laperle, Alexander H, Lawless, George, Myers, Zachary, Castro, Marian A, Villalba, Jaquelyn M, Svendsen, Clive N

“…While cells in the human body function in an environment where the blood supply constantly delivers nutrients and removes waste, cells in conventional tissue…”
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1-(2'-Bromobenzyl)-6,7-dihydroxy- N -methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D 2 Dopamine Receptors by Silva, Andrea G, Vila, Laura, Marques, Patrice, Moreno, Laura, Loza, Mabel, Sanz, María-Jesús, Cortes, Diego, Castro, Marián, Cabedo, Nuria

“…Certain D -like dopamine receptor (DR) agonists are useful therapeutically as antiparkinsonian drugs, whereas D -like DR antagonists or partial agonists are…”
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N -(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1 H - benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic by Kaczor, Agnieszka A, Targowska-Duda, Katarzyna M, Silva, Andrea G, Kondej, Magda, Biała, Grażyna, Castro, Marián

“…-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1 -benzimidazol -1-yl)propyl]piperidine-4-carboxamide (D2AAK4) is a multitarget ligand of aminergic G…”
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A subchronic history of binge-drinking elicits mild, age- and sex-selective, affective, and cognitive anomalies in C57BL/6J mice by Jimenez Chavez, C. Leonardo, Van Doren, Eliyana, Scheldrup, Gavin, Rivera, Emely, Torres-Gonzalez, Jose, Herbert, Jessica N., Denning, Christopher J. E., Khorsandi, Sarah, Garcia, Andrew, Castro, Marian, Szumlinski, Karen K.

“…Introduction Alcohol abuse is a risk factor for affective and cognitive disorders, with evidence indicating that adolescent-onset excessive drinking can result…”
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Application of BRET for studying G protein-coupled receptors by Kaczor, Agnieszka A, Makarska-Bialokoz, Magdalena, Selent, Jana, de la Fuente, Rocío A, Martí-Solano, Maria, Castro, Marián

“…G protein-coupled receptors (GPCRs) constitute one of the largest classes of cell surface receptors. GPCR biology has been a subject of widespread interest…”
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Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles by Selent, Jana, Marti-Solano, Maria, Rodríguez, Javier, Atanes, Patricio, Brea, José, Castro, Marian, Sanz, Ferran, Loza, M. Isabel, Pastor, Manuel

“…The clinical efficacy of antipsychotic drugs has been associated with a certain binding profile for a set of G protein-coupled receptors (GPCR)s. In this work,…”
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Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers by Brea, José, Castro, Marián, Giraldo, Jesús, López-Giménez, Juan F, Padín, Juan Fernando, Quintián, Fátima, Cadavid, Maria Isabel, Vilaró, Maria Teresa, Mengod, Guadalupe, Berg, Kelly A, Clarke, William P, Vilardaga, Jean-Pierre, Milligan, Graeme, Loza, Maria Isabel

“…The serotonin (5-hydroxytryptamine; 5-HT) 2A receptor is a cell surface class A G protein-coupled receptor that regulates a multitude of physiological…”
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A Rubric to Assess and Improve Technical Writing in Undergraduate Engineering Courses by Cantera, Maria Asun, Arevalo, María-José, García-Marina, Vanessa, Alves-Castro, Marian

“…Although there is consensus in the literature that writing skills are important in STEM (Science, Technology, Engineering, and Mathematics) studies, they are…”
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Analysis of University STEM Students’ Mathematical, Linguistic, Rhetorical–Organizational Assignment Errors by Arévalo, María-José, Cantera, María Asun, García-Marina, Vanessa, Alves-Castro, Marian

“…Although Error Analysis (EA) has been broadly used in Foreign Language and Mother Tongue learning contexts, it has not been applied in the field of engineering…”
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Ovariectomy-induced chronic abdominal hypernociception in rats: Relation with brain oxidative stress by Bárbara B. Garrido-Suárez, Gabino Garrido-Garrido, Marian Castro Labrada, Addis Bellma Menéndez, Roberto Menéndez Soto del Valle, René Delgado-Hernández

“…Context: Ovarian hormone deficiency observed in menopausal women increases the production of reactive oxygen species, which could be implicated in central…”
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder by Lacivita, Enza, Niso, Mauro, Mastromarino, Margherita, Garcia Silva, Andrea, Resch, Cibell, Zeug, Andre, Loza, María I, Castro, Marián, Ponimaskin, Evgeni, Leopoldo, Marcello

“…Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders characterized by core symptoms such as impaired social interaction and…”
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Discovery and in vitro Evaluation of Novel Serotonin 5‐HT 2A Receptor Ligands Identified Through Virtual Screening by Zięba, Agata, Bartuzi, Damian, Stępnicki, Piotr, Matosiuk, Dariusz, Wróbel, Tomasz M., Laitinen, Tuomo, Castro, Marián, Kaczor, Agnieszka A.

“…Abstract The 5‐HT 2A receptor is a molecular target of high pharmacological importance. Ligands of this protein, particularly atypical antipsychotics, are…”
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Anti-hyperalgesic effect of Mangifera indica L. extract on the sciatic chronic constriction injury model in rats by Bárbara B. Garrido-Suárez, Marian Castro Labrada, Nelson Merino, Odalys Valdés, René Delgado-Hernández

“…Context: The aqueous extract of Mangifera indica L. stem bark (MSBE) shows antioxidant, anti-inflammatory and analgesic properties. Aims: To test the MSBE in…”
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Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I by Garrido-Suárez, Bárbara B, Garrido, Gabino, Castro-Labrada, Marian, Pardo-Ruíz, Zenia, Bellma Menéndez, Addis, Spencer, Evelyn, Godoy-Figueiredo, Jozi, Ferreira, Sergio H, Delgado-Hernández, René

“…The present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible…”
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Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia by Stępnicki, Piotr, Wośko, Sylwia, Bartyzel, Agata, Zięba, Agata, Bartuzi, Damian, Szałaj, Klaudia, Wróbel, Tomasz M., Fornal, Emilia, Carlsson, Jens, Kędzierska, Ewa, Poleszak, Ewa, Castro, Marián, Kaczor, Agnieszka A.

“…The dopamine D2 receptor, which belongs to the family of G protein-coupled receptors (GPCR), is an important and well-validated drug target in the field of…”
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A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation by Buceta, Montserrat, Domínguez, Eduardo, Castro, Marián, Brea, José, Alvarez, David, Barcala, Javier, Valdés, Luis, Alvarez-Calderón, Pedro, Domínguez, Fernando, Vidal, Bernat, Díaz, Jose Luis, Miralpeix, Montse, Beleta, Jorge, Cadavid, María Isabel, Loza, María Isabel

“…Asthma is a chronic inflammatory disease of the airways that involves many cell types, amongst which mast cells are known to be important. Adenosine, a potent…”
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