Search Results - "CASTREN, Eero"

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB by Moliner, Rafael, Girych, Mykhailo, Brunello, Cecilia A., Kovaleva, Vera, Biojone, Caroline, Enkavi, Giray, Antenucci, Lina, Kot, Erik F., Goncharuk, Sergey A., Kaurinkoski, Katja, Kuutti, Mirjami, Fred, Senem M., Elsilä, Lauri V., Sakson, Sven, Cannarozzo, Cecilia, Diniz, Cassiano R. A. F., Seiffert, Nina, Rubiolo, Anna, Haapaniemi, Hele, Meshi, Elsa, Nagaeva, Elina, Öhman, Tiina, Róg, Tomasz, Kankuri, Esko, Vilar, Marçal, Varjosalo, Markku, Korpi, Esa R., Permi, Perttu, Mineev, Konstantin S., Saarma, Mart, Vattulainen, Ilpo, Casarotto, Plinio C., Castrén, Eero

“…Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We…”
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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors by Casarotto, Plinio C., Girych, Mykhailo, Fred, Senem M., Kovaleva, Vera, Moliner, Rafael, Enkavi, Giray, Biojone, Caroline, Cannarozzo, Cecilia, Sahu, Madhusmita Pryiadrashini, Kaurinkoski, Katja, Brunello, Cecilia A., Steinzeig, Anna, Winkel, Frederike, Patil, Sudarshan, Vestring, Stefan, Serchov, Tsvetan, Diniz, Cassiano R.A.F., Laukkanen, Liina, Cardon, Iseline, Antila, Hanna, Rog, Tomasz, Piepponen, Timo Petteri, Bramham, Clive R., Normann, Claus, Lauri, Sari E., Saarma, Mart, Vattulainen, Ilpo, Castrén, Eero

“…It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane…”
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Dysregulation of TrkB receptors and BDNF function by amyloid-β peptide is mediated by calpain by Jerónimo-Santos, André, Henriques Vaz, Sandra Cristina, Parreira, Sara, Lerias, Sofia, Caetano, António P., Buée-Scherrer, Valérie, Castrén, Eero, Valente, Cláudia, Blum, David, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José

“…© The Author 2014. Published by Oxford University Press. All rights reserved. Brain-derived neurotrophic factor (BDNF) and its high-affinity full-length (FL)…”
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Brain-derived neurotrophic factor in mood disorders and antidepressant treatments by Castrén, Eero, Kojima, Masami

“…Abstract Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels…”
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Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X‐box promoter motifs by Tammimies, Kristiina, Bieder, Andrea, Lauter, Gilbert, Sugiaman‐Trapman, Debora, Torchet, Rachel, Hokkanen, Marie‐Estelle, Burghoorn, Jan, Castren, Eero, Kere, Juha, Tapia‐Páez, Isabel, Swoboda, Peter

“…ABSTRACT DYX1C1, DCDC2, and KIAA0319 are three of the most replicated dyslexia candidate genes (DCGs). Recently, these DCGs were implicated in functions at the…”
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Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy by Heinrich, Christophe, Lähteinen, Sari, Suzuki, Fumio, Anne-Marie, Laharie, Huber, Susanne, Häussler, Ute, Haas, Carola, Larmet, Yves, Castren, Eero, Depaulis, Antoine

“…Abstract Mesio-temporal lobe epilepsy (MTLE), the most common drug-resistant epilepsy syndrome, is characterized by the recurrence of spontaneous focal…”
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Brain plasticity and neuroinflammatory protein biomarkers with circulating MicroRNAs as predictors of acute brain injury outcome – A prospective cohort study by Sajanti, Antti, Li, Yan, Hellström, Santtu, Cao, Ying, Girard, Romuald, Umemori, Juzoh, Frantzén, Janek, Koskimäki, Fredrika, Lyne, Seán B., Falter, Johannes, Rantamäki, Tomi, Takala, Riikka, Posti, Jussi P., Roine, Susanna, Kolehmainen, Sulo, Srinath, Abhinav, Jänkälä, Miro, Puolitaival, Jukka, Rahi, Melissa, Rinne, Jaakko, Castrén, Eero, Koskimäki, Janne

“…Brain recovery mechanisms after injuries like aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI) involve brain…”
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Depolarizing γ‐aminobutyric acid contributes to glutamatergic network rewiring in epilepsy by Kourdougli, Nazim, Pellegrino, Christophe, Renko, Juho‐Matti, Khirug, Stanislav, Chazal, Geneviève, Kukko‐Lukjanov, Tiina‐Kaisa, Lauri, Sari E., Gaiarsa, Jean‐Luc, Zhou, Liang, Peret, Angélique, Castrén, Eero, Tuominen, Raimo K., Crépel, Valérie, Rivera, Claudio

“…Objective Rewiring of excitatory glutamatergic neuronal circuits is a major abnormality in epilepsy. Besides the rewiring of excitatory circuits, an abnormal…”
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Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action by Castrén, Eero, Monteggia, Lisa M.

“…Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been associated with depression and antidepressant drug action. A variety of…”
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Neuronal network plasticity and recovery from depression by Castrén, Eero

“…The brain processes sensory information in neuronal networks that are shaped by experience, particularly during early life, to optimally represent the internal…”
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Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons by Massinen, Satu, Hokkanen, Marie-Estelle, Matsson, Hans, Tammimies, Kristiina, Tapia-Páez, Isabel, Dahlström-Heuser, Vanina, Kuja-Panula, Juha, Burghoorn, Jan, Jeppsson, Kristian E, Swoboda, Peter, Peyrard-Janvid, Myriam, Toftgård, Rune, Castrén, Eero, Kere, Juha

“…DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to…”
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Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling by Song, Minseok, Giza, Joanna, Proenca, Catia C., Jing, Deqiang, Elliott, Mark, Dincheva, Iva, Shmelkov, Sergey V., Kim, Jihye, Schreiner, Ryan, Huang, Shu-Hong, Castrén, Eero, Prekeris, Rytis, Hempstead, Barbara L., Chao, Moses V., Dictenberg, Jason B., Rafii, Shahin, Chen, Zhe-Yu, Rodriguez-Boulan, Enrique, Lee, Francis S.

“…Recent studies in humans and in genetic mouse models have identified Slit- and NTRK-like family (Slitrks) as candidate genes for neuropsychiatric disorders…”
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Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine by Pryazhnikov, Evgeny, Mugantseva, Ekaterina, Casarotto, Plinio, Kolikova, Julia, Fred, Senem Merve, Toptunov, Dmytro, Afzalov, Ramil, Hotulainen, Pirta, Voikar, Vootele, Terry-Lorenzo, Ryan, Engel, Sharon, Kirov, Sergei, Castren, Eero, Khiroug, Leonard

“…Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid…”
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Neurochemistry of the antidepressant effect – a misunderstanding? by Castrén, Eero

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GDNF is not required for catecholaminergic neuron survival in vivo by Kopra, Jaakko, Vilenius, Carolina, Grealish, Shane, Härma, Mari-Anne, Varendi, Kärt, Lindholm, Jesse, Castrén, Eero, Võikar, Vootele, Björklund, Anders, Piepponen, T Petteri, Saarma, Mart, Andressoo, Jaan-Olle

“…Glial cell line-derived neurotrophic factor (GDNF) is in clinical trials for treating Parkinson's disease. However, endogenous GDNF function in brain…”
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Is mood chemistry? by CASTREN, Eero

“…The chemical hypothesis of depression suggests that mood disorders are caused by a chemical imbalance in the brain, which can be corrected by antidepressant…”
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Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression by Kraus, Christoph, Castrén, Eero, Kasper, Siegfried, Lanzenberger, Rupert

“…•We show links between serotonin and neuroplasticity in depression and antidepressant treatment.•Serotonin reuptake inhibitors mediate development-like…”
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Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries-A Prospective Cohort Study by Hellström, Santtu, Sajanti, Antti, Srinath, Abhinav, Bennett, Carolyn, Girard, Romuald, Cao, Ying, Frantzén, Janek, Koskimäki, Fredrika, Falter, Johannes, Lyne, Seán B, Rantamäki, Tomi, Takala, Riikka, Posti, Jussi P, Roine, Susanna, Puolitaival, Jukka, Jänkälä, Miro, Kolehmainen, Sulo, Rahi, Melissa, Rinne, Jaakko, Castrén, Eero, Koskimäki, Janne

“…Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of…”
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The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity by Castren, Eero, Rantamaki, Tomi

“…Recent evidence suggests that neuronal plasticity plays an important role in the recovery from depression. Antidepressant drugs and electroconvulsive shock…”
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Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro by Martin, Mauricio G, Perga, Simona, Trovò, Laura, Rasola, Andrea, Holm, Pontus, Rantamäki, Tomi, Harkany, Tibor, Castrén, Eero, Chiara, Federica, Dotti, Carlos G

“…Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development. In the…”
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