Search Results - "CASTILHO, Beatriz A."

Keeping the eIF2 alpha kinase Gcn2 in check by Castilho, Beatriz A., Shanmugam, Renuka, Silva, Richard C., Ramesh, Rashmi, Himme, Benjamin M., Sattlegger, Evelyn

“…The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest due to its involvement in a large array of crucial biological…”
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Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms by Tonelli, Renata R, Augusto, Leonardo da Silva, Castilho, Beatriz A, Schenkman, Sergio

“…Chagas' disease is a potentially life-threatening illness caused by the unicellular protozoan parasite Trypanosoma cruzi. It is transmitted to humans by…”
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Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR by Roffé, Martín, Beraldo, Flávio Henrique, Bester, Romina, Nunziante, Max, Bach, Christian, Mancini, Gabriel, Gilch, Sabine, Vorberg, Ina, Castilho, Beatriz A., Martins, Vilma Regina, Hajj, Glaucia Noeli Maroso, Weissmann, Charles

“…Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrP C ) into an infectious isoform…”
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A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi by da Silva Augusto, Leonardo, Moretti, Nilmar Silvio, Ramos, Thiago Cesar Prata, de Jesus, Teresa Cristina Leandro, Zhang, Min, Castilho, Beatriz A, Schenkman, Sergio

“…Translation initiation has been described as a key step for the control of growth and differentiation of several protozoan parasites in response to…”
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The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control by Pereira, Catia M, Filev, Renato, Dubiela, Francisco P, Brandão, Bruna B, Queiroz, Claudio M, Ludwig, Raissa G, Hipolide, Debora, Longo, Beatriz M, Mello, Luiz E, Mori, Marcelo A, Castilho, Beatriz A

“…IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT…”
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Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells by Chung, Janete, Rocha, Antonio A, Tonelli, Renata R, Castilho, Beatriz A, Schenkman, Sergio

“…The protein known as eIF5A (eukaryotic initiation factor 5A) has an elusive role in translation. It has a unique and essential hypusine modification at a…”
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Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins by Akram, Zain, Ahmed, Ishtiaq, Mack, Heike, Kaur, Ramandeep, Silva, Richard C, Castilho, Beatriz A, Friant, Sylvie, Sattlegger, Evelyn, Munn, Alan L

“…The budding yeast has an actin cytoskeleton that comprises a set of protein components analogous to those found in the actin cytoskeletons of higher…”
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Topical Dexamethasone Administration Impairs Protein Synthesis and Neuronal Regeneration in the Olfactory Epithelium by Crisafulli, Umberto, Xavier, André M, Dos Santos, Fabiana B, Cambiaghi, Tavane D, Chang, Seo Y, Porcionatto, Marimélia, Castilho, Beatriz A, Malnic, Bettina, Glezer, Isaias

“…Chronic inflammatory process in the nasal mucosa is correlated with poor smell perception. Over-activation of immune cells in the olfactory epithelium (OE) is…”
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The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast by Silva, Richard C, Dautel, Martina, Di Genova, Bruno M, Amberg, David C, Castilho, Beatriz A, Sattlegger, Evelyn

“…The Saccharomyces cerevisiae protein Yih1, when overexpressed, inhibits the eIF2 alpha kinase Gcn2 by competing for Gcn1 binding. However, deletion of YIH1 has…”
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GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice by Orsini, Heloisa, Araujo, Leandro P, Maricato, Juliana T, Guereschi, Marcia G, Mariano, Mario, Castilho, Beatriz A, Basso, Alexandre S

“…Abstract Experimental autoimmune encephalomyelitis (EAE) has been widely employed as a model to study multiple sclerosis (MS) and indeed has allowed some…”
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Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects by Guerra, Beatriz A., Brandão, Bruna B., Pinto, Silas S., Salgueiro, Willian G., De-Souza, Evandro A., Reis, Felipe C.G., Batista, Thiago M., Cavalcante-Silva, Vanessa, D'Almeida, Vânia, Castilho, Beatriz A., Carneiro, Everardo M., Antebi, Adam, Festuccia, William T., Mori, Marcelo A.

“…Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we…”
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A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α by Silva, Richard C, Castilho, Beatriz A, Sattlegger, Evelyn

“…Many studies require the detection and relative quantitation of proteins from cell culture samples using immunoblotting. Limiting factors are the cost of…”
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NIP7 protein is required for accurate pre-rRNA processing in human cells by Morello, Luis G, Hesling, Cédric, Coltri, Patrícia P, Castilho, Beatriz A, Rimokh, Ruth, Zanchin, Nilson I.T

“…Eukaryotic ribosome biogenesis requires the function of a large number of trans-acting factors which interact transiently with the nascent pre-rRNA and…”
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Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response by Silva, Richard C, Sattlegger, Evelyn, Castilho, Beatriz A

“…Genetic and pharmacological interventions in yeast and mammalian cells have suggested a cross-talk between the actin cytoskeleton and protein synthesis…”
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Novel Membrane-Bound eIF2α Kinase in the Flagellar Pocket of Trypanosoma brucei by Moraes, Maria Carolina S., Jesus, Teresa C. L., Hashimoto, Nilce N., Dey, Madhusudan, Schwartz, Kevin J., Alves, Viviane S., Avila, Carla C., Bangs, James D., Dever, Thomas E., Schenkman, Sergio, Castilho, Beatriz A.

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation by Pereira, Cátia M, Sattlegger, Evelyn, Jiang, Hao-Yuan, Longo, Beatriz M, Jaqueta, Carolina B, Hinnebusch, Alan G, Wek, Ronald C, Mello, Luiz E A M, Castilho, Beatriz A

“…Translational control directed by the eukaryotic translation initiation factor 2 α-subunit (eIF2α) kinase GCN2 is important for coordinating gene expression…”
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Salicylates Trigger Protein Synthesis Inhibition in a Protein Kinase R-like Endoplasmic Reticulum Kinase-dependent Manner by Silva, Aristóbolo M., Wang, Die, Komar, Anton A., Castilho, Beatriz A., Williams, Bryan R.G.

“…The non-steroidal anti-inflammatory drug aspirin and its metabolite, sodium salicylate, have profound effects on cellular protein synthesis and cell…”
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Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus by Carnevalli, Larissa S, Pereira, Catia M, Jaqueta, Carolina B, Alves, Viviane S, Paiva, Vanessa N, Vattem, Krishna M, Wek, Ronald C, Mello, Luiz Eugênio A M, Castilho, Beatriz A

“…In response to different cellular stresses, a family of protein kinases phosphorylates eIF2alpha (alpha subunit of eukaryotic initiation factor-2),…”
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IMPACT Is a Developmentally Regulated Protein in Neurons That Opposes the Eukaryotic Initiation Factor 2α Kinase GCN2 in the modulation of Neurite Outgrowth by Roffé, Martín, Hajj, Glaucia N.M., Azevedo, Hátylas F., Alves, Viviane S., Castilho, Beatriz A.

“…The product of the mouse Imprinted and Ancient gene, IMPACT, is preferentially expressed in neurons. We have previously shown that IMPACT overexpression…”
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Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 by Cambiaghi, Tavane D., Pereira, Catia M., Shanmugam, Renuka, Bolech, Michael, Wek, Ronald C., Sattlegger, Evelyn, Castilho, Beatriz A.

“…•GCN1 is required for mammalian and yeast GCN2 function in a variety of conditions.•Mammalian IMPACT competes with GCN2 for GCN1 binding.•IMPACT and its yeast…”
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