Search Results - "CASTIGLIA, Sara"
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A Novel Xeno-Free Method to Isolate Human Endometrial Mesenchymal Stromal Cells (E-MSCs) in Good Manufacturing Practice (GMP) Conditions
Published in International journal of molecular sciences (09-02-2022)“…The cyclic regeneration of human endometrium is guaranteed by the proliferative capacity of endometrial mesenchymal stromal cells (E-MSCs). Due to this, the…”
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Cytokines induced killer cells produced in good manufacturing practices conditions: identification of the most advantageous and safest expansion method in terms of viability, cellular growth and identity
Published in Journal of translational medicine (29-08-2018)“…Cytokine-induced killer (CIK) cells are a very promising cell population raising growing interest in the field of cellular antitumor therapy. The aim of our…”
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Inter-laboratory method validation of CD34+ flow-cytometry assay: the experience of Turin Metropolitan Transplant Centre
Published in EJIFCC (01-10-2023)“…The Turin Metropolitan Transplant Centre (CIC 305) includes four flow-cytometry laboratories assessing quality control on hematopoietic stem cells (HSC) with…”
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Cytokine-Induced Killer (CIK) Cells, In Vitro Expanded under Good Manufacturing Process (GMP) Conditions, Remain Stable over Time after Cryopreservation
Published in Pharmaceuticals (Basel, Switzerland) (12-05-2020)“…Cytokine-induced killer (CIK) cells are advanced therapy medicinal products, so their production and freezing process has to be validated before their clinical…”
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Validation of the media fill method for Cytokine-Induced killer cells manufacturing process
Published in Translational medicine communications (11-08-2023)“…Abstract Background Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good…”
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Correction to: Cytokines induced killer cells produced in good manufacturing practices conditions: identification of the most advantageous and safest expansion method in terms of viability, cellular growth and identity
Published in Journal of translational medicine (10-10-2018)“…Following publication of the original article [1], the authors reported that all of the authors' names were processed incorrectly so that their given and…”
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Multipotent Mesenchymal Stromal Stem Cell Expansion by Plating Whole Bone Marrow at a Low Cellular Density: A More Advantageous Method for Clinical Use
Published in Stem Cells International (01-01-2012)“…Mesenchymal stem cells (MSCs) are a promising source for cell therapy due to their pluripotency and immunomodulant proprieties. As the identification of…”
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Validation of analytical methods in GMP: the disposable Fast Read 102® device, an alternative practical approach for cell counting
Published in Journal of translational medicine (31-05-2012)“…The quality and safety of advanced therapy products must be maintained throughout their production and quality control cycle to ensure their final use in…”
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Inactivated Platelet Lysate Supports the Proliferation and Immunomodulant Characteristics of Mesenchymal Stromal Cells in GMP Culture Conditions
Published in Biomedicines (17-07-2020)“…Mesenchymal stromal cells (MSCs) isolated from bone marrow (BM-MSCs) are considered advanced therapy medicinal products (ATMPs) and need to be produced…”
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Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury
Published in Thrombosis and haemostasis (01-11-2009)“…Heparin and low molecular weight heparins may reduce brain damage evoked by ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of…”
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RETRACTED: Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
Published in British journal of pharmacology (01-08-2010)“…Background and purpose: Nutrient overload leads to obesity and insulin resistance. Pioglitazone, a selective peroxisome proliferator‐activated receptor (PPAR)γ…”
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Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats
Published in Diabetes (New York, N.Y.) (01-01-2009)“…Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats A Role for Glycogen Synthase Kinase-3β Massimo Collino 1 , Manuela…”
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Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta
Published in Experimental hematology (01-02-2016)“…Mesenchymal stromal cells (MSCs) are a promising tool in cell therapies because of their multipotent, bystander, and immunomodulatory properties. Although bone…”
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Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
Published in British journal of pharmacology (01-08-2010)“…Background and purpose: Nutrient overload leads to obesity and insulin resistance. Pioglitazone, a selective peroxisome proliferator‐activated receptor…”
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Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat
Published in Shock (Augusta, Ga.) (01-08-2010)“…Peroxisome proliferator-activated receptor-beta/delta (PPAR-beta/delta) is a transcription factor that belongs to the PPAR nuclear hormone receptor family…”
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Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats : A Role for Glycogen Synthase Kinase-3β
Published in Diabetes (New York, N.Y.) (2009)“…OBJECTIVE--There is evidence that insulin reduces brain injury evoked by ischemia/reperfusion (I/R). However, the molecular mechanisms underlying the…”
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In Vitro Mesenchymal Progenitor Cell Expansion is a Predictor of Transplant-related Mortality and acute GvHD III-IV After Bone Marrow Transplantation in Univariate Analysis: A Large Single-Center Experience
Published in Journal of pediatric hematology/oncology (01-01-2019)“…Mesenchymal stromal cells (MSCs) are multipotent stem cells able to differentiate into mesenchymal origin tissue and support the growth of hematopoietic stem…”
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Inactivated human platelet lysate with psoralen: a new perspective for mesenchymal stromal cell production in Good Manufacturing Practice conditions
Published in Cytotherapy (Oxford, England) (01-06-2014)“…Abstract Background aims Mesenchymal stromal cells (MSC) are ideal candidates for regenerative and immunomodulatory therapies. The use of xenogeneic…”
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Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction
Published in Laboratory investigation (01-10-2008)“…The generation of endogenous hydrogen sulfide may either limit or contribute to the degree of tissue injury caused by ischemia/reperfusion. A total of 74 male…”
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Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
Published in Free radical biology & medicine (15-01-2011)“…Diabetes is an important risk factor for ischemic acute kidney injury, whose pharmacological treatment remains an unmet medical need. The peroxisome…”
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