Search Results - "CASTELL, José V"

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved by Martínez-Sena, Teresa, Moro, Erika, Moreno-Torres, Marta, Quintás, Guillermo, Hengstler, Jan, Castell, José V.

“…Toxicity studies, among them hepatotoxicity, are key throughout preclinical stages of drug development to minimise undesired toxic effects that might…”
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The assessment of the potential hepatotoxicity of new drugs by in vitro metabolomics by Quintás, Guillermo, Castell, José V, Moreno-Torres, Marta

“…Drug hepatotoxicity assessment is a relevant issue both in the course of drug development as well as in the post marketing phase. The use of human relevant…”
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Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways by Petrov, Petar D., Soluyanova, Polina, Sánchez-Campos, Sonia, Castell, José V., Jover, Ramiro

“…Treatment of β-lactamase positive bacterial infections with a combination of amoxicillin (AMOX) and clavulanic acid (CLAV) causes idiosyncratic drug-induced…”
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A microRNA signature for valproate-induced steatosis in human hepatocytes and its application to predict fatty liver in paediatric epileptic patients on valproate therapy by Soluyanova, Polina, del Pozo, Marta, Moro-Castaño, Erika, Marco-Hernández, Ana V., Castell, José V., Jover, Ramiro

“…Valproate (VPA) has been the first-line, most frequently prescribed antiepileptic drug in children over the past 50 years. VPA causes, idiosyncratic…”
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The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment by Moreno-Torres, Marta, Quintás, Guillermo, Castell, José V.

“…Drug-induced liver injury (DILI) is one of the most frequent adverse clinical reactions and a relevant cause of morbidity and mortality. Hepatotoxicity is…”
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A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes by Moreno-Torres, Marta, Kumar, Manoj, García-Llorens, Guillem, Quintás, Guillermo, Tricot, Tine, Boon, Ruben, Tolosa, Laia, Toprakhisar, Burak, Chesnais, Francois, Verfaillie, Catherine, Castell, José V

“…Typical protocols to differentiate induced pluripotent stem cells (iPSCs) from hepatocyte-like cells (HLCs) imply complex strategies that include transfection…”
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Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat by Quintás, Guillermo, Caiment, Florian, Rienda, Iván, Pérez-Rojas, Judith, Pareja, Eugenia, Castell, José V, Jover, Ramiro

“…Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease worldwide, but a reliable non-invasive method to quantify liver…”
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Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile by Moya, Marta, José Gómez-Lechón, M., Castell, José V., Jover, Ramiro

“…Steatosis is the first step in the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms involved in its pathogenesis are not fully…”
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A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients by Baier, Vanessa, Cordes, Henrik, Thiel, Christoph, Castell, José V., Neumann, Ulf P., Blank, Lars M., Kuepfer, Lars

“…Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and patient safety, often leading to discontinuation of…”
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Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics by Ten-Doménech, Isabel, Martínez-Sena, Teresa, Moreno-Torres, Marta, Sanjuan-Herráez, Juan Daniel, Castell, José V., Parra-Llorca, Anna, Vento, Máximo, Quintás, Guillermo, Kuligowski, Julia

“…One of the most widely used strategies for metabolite annotation in untargeted LCMS is based on the analysis of MSn spectra acquired using data-dependent…”
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CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene: APPLICATION TO THE DEVELOPMENT OF A METABOLICALLY COMPETENT HUMAN HEPATIC CELL MODEL by Benet, Marta, Lahoz, Agustín, Guzmán, Carla, Castell, José V, Jover, Ramiro

“…The transcription of tissue-specific and inducible genes is usually subject to the dynamic control of multiple activators. Dedifferentiated hepatic cell lines…”
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Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved by Jover, Ramiro, Bort, Roque, Gómez‐Lechón, Ma. José, Castell, José V.

“…The hepatic drug‐metabolizing cytochrome P‐450 (CYP) enzymes are down‐regulated during inflammation. In vitro studies with hepatocytes have shown that the…”
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Underexpressed Coactivators PGC1α AND SRC1 Impair Hepatocyte Nuclear Factor 4α Function and Promote Dedifferentiation in Human Hepatoma Cells by Martínez-Jiménez, Celia P., Gómez-Lechón, M. José, Castell, José V., Jover, Ramiro

“…Hepatocyte nuclear factor 4α (HNF4α) plays critical roles during liver development and in the transcriptional regulation of many hepatic genes in adult liver…”
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The use of hepatocytes to investigate drug toxicity by Gómez-Lechón, María José, Castell, José V, Donato, María Teresa

“…The liver is very active in metabolizing foreign compounds and the major target for toxicity caused by drugs. Hepatotoxicity may be the result of the drug…”
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FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES by Donato, M Teresa, Jiménez, Nuria, Castell, José V, Gómez-Lechón, M José

“…In this study we describe a battery of fluorescence assays for rapid measurement in intact cells of the activity of nine cytochromes P450 (P450s) involved in…”
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An update on metabolism studies using human hepatocytes in primary culture by Gómez-Lechón, María José, Castell, José V, Donato, María Teresa

“…Cultured human hepatocytes are the closest in vitro model to human liver and constitute a very predictive model for drug metabolism in vivo. The variability…”
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ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses by PASCUAL, Maya, GOMEZ-LECHON, M. Jose, CASTELL, José V, JOVER, Ramiro

“…Activating transcription factor (ATF) 5 is a member of the ATF/cAMP response element-binding protein family, which has been associated with differentiation,…”
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Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach by Castell, José V., Teresa Donato, M., Gómez-Lechón, María José

“…Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is frequently exposed to elevated concentrations of these compounds and…”
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Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS by Gómez-Lechón, M.José, Ponsoda, Xavier, O’Connor, Enrique, Donato, Teresa, Castell, José V., Jover, Ramiro

“…Diclofenac is a non-steroidal anti-inflammatory drug that is widely used clinically but side effects associated with the administration of the drug have been…”
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Allergic hepatitis induced by drugs by Castell, José V, Castell, Marta

“…PURPOSE OF REVIEWTo examine recent advances in our understanding of how drugs can trigger a hypersensitivity reaction in the liver, how tolerance is lost, the…”
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