Search Results - "CASTELIJNS, Bas"
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Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
Published in Nature communications (16-01-2020)“…Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and…”
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Arabidopsis BIRD Zinc Finger Proteins Jointly Stabilize Tissue Boundaries by Confining the Cell Fate Regulator SHORT-ROOT and Contributing to Fate Specification
Published in The Plant cell (01-04-2015)“…Plant cells cannot rearrange their positions; therefore, sharp tissue boundaries must be accurately programmed. Movement of the cell fate regulator SHORT-ROOT…”
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Epigenomic annotation of gene regulatory alterations during evolution of the primate brain
Published in Nature neuroscience (01-03-2016)“…Gene-regulatory elements are drivers of evolutionary divergence, yet where these are located and which are evolutionarily relevant is unclear. In this work,…”
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Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis
Published in Frontiers in immunology (04-01-2023)“…Dendritic cells (DC) are crucial for initiating and shaping immune responses. So far, little is known about the functional specialization of human DC subsets…”
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GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology
Published in Plant physiology (Bethesda) (01-07-2013)“…Plant synthetic biology aims to apply engineering principles to plant genetic design. One strategic requirement of plant synthetic biology is the adoption of…”
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Recently Evolved Enhancers Emerge with High Interindividual Variability and Less Frequently Associate with Disease
Published in Cell reports (Cambridge) (23-06-2020)“…Mutations in non-coding regulatory DNA such as enhancers underlie a wide variety of diseases including developmental disorders and cancer. As enhancers rapidly…”
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GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology
Published in Plant physiology (Bethesda) (01-07-2013)Get full text
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A coat-independent superinfection exclusion rapidly imposed in Nicotiana benthamiana cells by tobacco mosaic virus is not prevented by depletion of the movement protein
Published in Plant molecular biology (01-04-2013)“…New evidence is emerging which indicates that population variants in plant virus infections are not uniformly distributed along the plant, but structured in a…”
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GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology1[C][W][OA]
Published in Plant physiology (Bethesda) (13-05-2013)“…GoldenBraid 2.0 is a comprehensive technological framework that facilitates the construction of increasingly complex multigene structures and exchange of…”
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Dissection of TAF1 neuronal splicing and implications for neurodegeneration in X-linked dystonia-parkinsonism
Published in Brain communications (01-10-2021)“…Abstract X-linked dystonia-parkinsonism (XDP) is a monogenic neurodegenerative disorder of the basal ganglia, which presents as a combination of hyperkinetic…”
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A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels
Published in Journal of biomolecular screening (01-02-2014)“…Posttranslational modifications of histones play an important role in the regulation of gene expression and chromatin structure in eukaryotes. The balance…”
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