Search Results - "CASTEDO, MARIA"

Mitotic catastrophe: a mechanism for avoiding genomic instability by Kroemer, Guido, Vitale, Ilio, Galluzzi, Lorenzo, Castedo, Maria

“…The improper distribution of chromosomes during mitosis can contribute to malignant transformation. Higher eukaryotes have developed strategies for eliminating…”
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Metabolic vulnerability of cisplatin‐resistant cancers by Obrist, Florine, Michels, Judith, Durand, Sylvere, Chery, Alexis, Pol, Jonathan, Levesque, Sarah, Joseph, Adrien, Astesana, Valentina, Pietrocola, Federico, Wu, Gen Sheng, Castedo, Maria, Kroemer, Guido

“…Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical…”
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PARP1 inhibition elicits immune responses against non-small cell lung cancer by Juncheng, Pan, Lafarge, Antoine, Kroemer, Guido, Castedo, Maria

“…High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of…”
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Calreticulin exposure dictates the immunogenicity of cancer cell death by Obeid, Michel, Tesniere, Antoine, Ghiringhelli, François, Fimia, Gian Maria, Apetoh, Lionel, Perfettini, Jean-Luc, Castedo, Maria, Mignot, Grégoire, Panaretakis, Theoharis, Casares, Noelia, Métivier, Didier, Larochette, Nathanael, van Endert, Peter, Ciccosanti, Fabiola, Piacentini, Mauro, Zitvogel, Laurence, Kroemer, Guido

“…Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune response, whereas other DNA-damaging agents such as etoposide and…”
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Autophagic removal of micronuclei by Rello-Varona, Santiago, Lissa, Delphine, Shen, Shensi, Niso-Santano, Mireia, Senovilla, Laura, Mariño, Guillermo, Vitale, Ilio, Jemaá, Mohamed, Harper, Francis, Pierron, Gérard, Castedo, Maria, Kroemer, Guido

“…Macroautophagy is known to participate in the quality control and turnover of cytoplasmic organelles, yet there is little evidence that macroautophagy targets…”
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Cell death by mitotic catastrophe: a molecular definition by Castedo, Maria, Perfettini, Jean-Luc, Roumier, Thomas, Andreau, Karine, Medema, Rene, Kroemer, Guido

“…The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell death that occurs during mitosis. Here, we propose that…”
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Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death by Castedo, Maria, Lafarge, Antoine, Kroemer, Guido

“…The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and…”
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Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos by Vitale, Ilio, Senovilla, Laura, Jemaà, Mohamed, Michaud, Mickaël, Galluzzi, Lorenzo, Kepp, Oliver, Nanty, Lisa, Criollo, Alfredo, Rello-Varona, Santiago, Manic, Gwenola, Métivier, Didier, Vivet, Sonia, Tajeddine, Nicolas, Joza, Nicholas, Valent, Alexander, Castedo, Maria, Kroemer, Guido

“…Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only…”
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Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention by Lissa, Delphine, Senovilla, Laura, Rello-Varona, Santiago, Vitale, IIio, Michaud, Mickaël, Pietrocola, Federico, Boilève, Alice, Obrist, Florine, Bordenave, Chloé, Garcia, Pauline, Michels, Judith, Jemaà, Mohamed, Kepp, Oliver, Castedo, Maria, Kroemer, Guido

“…Tetraploidy constitutes a genomically metastable state that can lead to aneuploidy and genomic instability. Tetraploid cells are frequently found in…”
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Inhibition of acyl-CoA binding protein (ACBP) by means of a GABAARγ2-derived peptide by Anagnostopoulos, Gerasimos, Saavedra, Ester, Lambertucci, Flavia, Motiño, Omar, Dimitrov, Jordan, Roiz-Valle, David, Quesada, Victor, Alvarez-Valadez, Karla, Chen, Hui, Sauvat, Allan, Rong, Yan, Nogueira-Recalde, Uxía, Li, Sijing, Montégut, Léa, Djavaheri-Mergny, Mojgan, Castedo, Maria, Lopez-Otin, Carlos, Maiuri, Maria Chiara, Martins, Isabelle, Kroemer, Guido

“…Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A…”
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Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index by Joseph, Adrien, Chen, Hui, Anagnostopoulos, Gerasimos, Montégut, Léa, Lafarge, Antoine, Motiño, Omar, Castedo, Maria, Maiuri, Maria Chiara, Clément, Karine, Terrisse, Safae, Martin, Anne Laure, Vaz-Luis, Ines, Andre, Fabrice, Grundler, Franziska, de Toledo, Françoise Wilhelmi, Madeo, Frank, Zitvogel, Laurence, Goldwasser, François, Blanchet, Benoit, Fumeron, Frédéric, Roussel, Ronan, Martins, Isabelle, Kroemer, Guido

“…In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called…”
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Functions of BCL-XL at the Interface between Cell Death and Metabolism by Michels, Judith, Kepp, Oliver, Senovilla, Laura, Lissa, Delphine, Castedo, Maria, Kroemer, Guido, Galluzzi, Lorenzo

“…The BCL-2 homolog BCL-XL, one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions. Similar to…”
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Metabolic enzymes expressed by cancer cells impact the immune infiltrate by Stoll, Gautier, Kremer, Margerie, Bloy, Normal, Joseph, Adrien, Castedo, Maria, Meurice, Guillaume, Klein, Christophe, Galluzzi, Lorenzo, Michels, Judith, Kroemer, Guido

“…The expression of two metabolic enzymes, i.e., aldehyde dehydrogenase 7 family, member A1 (ALDH7A1) and lipase C, hepatic type (LIPC) by malignant cells, has…”
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Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer by Michels, Judith, Vitale, Ilio, Senovilla, Laura, Enot, David P., Garcia, Pauline, Lissa, Delphine, Olaussen, Ken A., Brenner, Catherine, Soria, Jean-Charles, Castedo, Maria, Kroemer, Guido

“…The antineoplastic agent cis-diammineplatinum(II) dichloride (cisplatin, CDDP) is part of the poorly effective standard treatment of non-small cell lung…”
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Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells by Vitale, Ilio, Manic, Gwenola, Castedo, Maria, Kroemer, Guido

“…Mitotic catastrophe is an oncosuppressive mechanism that targets cells experiencing defective mitoses via the activation of specific cell cycle checkpoints,…”
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Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers by Joseph, Adrien, Pan, Juncheng, Michels, Judith, Kroemer, Guido, Castedo, Maria

“…Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported…”
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Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer by Juncheng, Pan, Joseph, Adrien, Lafarge, Antoine, Martins, Isabelle, Obrist, Florine, Pol, Jonathan, Saavedra, Ester, Li, Sijing, Sauvat, Allan, Cerrato, Giulia, Lévesque, Sarah, Leduc, Marion, Kepp, Oliver, Durand, Sylvère, Aprahamian, Fanny, Nirmalathansan, Nitharsshini, Michels, Judith, Kroemer, Guido, Castedo, Maria

“…BackgroundHigh activity of poly(ADP-ribose) polymerase-1 (PARP1) in non-small cell lung cancer (NSCLC) cells leads to an increase in immunohistochemically…”
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Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy by CASTEDO, Maria, PERFETTINI, Jean-Luc, VAINCHENKER, William, KROEMER, Guido, ROUMIER, Thomas, VALENT, Alexander, RASLOVA, Hana, YAKUSHIJIN, Kenichi, HORNE, David, FEUNTEUN, Jean, LENOIR, Gilbert, MEDEMA, René

“…A conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe when the DNA structure checkpoints are inactivated, for instance when the…”
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Tetraploid cancer cell precursors in ovarian carcinoma by Castedo, Maria, Senovilla, Laura, Vitale, Ilio, Kroemer, Guido

“…Comment on: Lv L, et al. Cell Cycle 2012; 11:2864-75…”
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Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope by Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, Larochette, Nathanael, Piacentini, Mauro, Kroemer, Guido

“…The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia…”
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