Search Results - "CASPER, Martin"

Structure−Activity Relationships of Novel 2-Substituted Quinazoline Antibacterial Agents by Kung, Pei-Pei, Casper, Martin D, Cook, Kimberley L, Wilson-Lingardo, Laura, Risen, Lisa M, Vickers, Timothy A, Ranken, Ray, Blyn, Lawrence B, Wyatt, Jacqueline R, Cook, P. Dan, Ecker, David J

“…High-throughput screening of in-house compound libraries led to the discovery of a novel antibacterial agent, compound 1 (MIC:  12−25 μM against S. pyogenes)…”
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Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis by Xiong, Yifeng, Teegarden, Bradley R, Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I, Casper, Martin D, Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R, Connolly, Daniel T, Semple, Graeme, Al-Shamma, Hussien

“…Serotonin, which is stored in platelets and is released during thrombosis, activates platelets via the 5-HT2A receptor. 5-HT2A receptor inverse agonists thus…”
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Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: In vitro profiling and in vivo evaluation by Semple, Graeme, Tran, Thuy-Anh, Kramer, Bryan, Hsu, Debbie, Han, Sangdon, Choi, Juyi, Vallar, Pureza, Casper, Martin D., Zou, Ning, Hauser, Erin K., Thomsen, William, Whelan, Kevin, Sengupta, Dipanjan, Morgan, Michael, Sekiguchi, Yoshinori, Kanuma, Kosuke, Chaki, Shigeyuki, Grottick, Andrew J.

“…A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro with improved receptor selectivity. One example was…”
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Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets by Kawasaki, Andrew M, Casper, Martin D, Freier, Susan M, Lesnik, Elena A, Zounes, Maryann C, Cummins, Lendell L, Gonzalez, Carolyn, Cook, P. Dan

“…"Uniformly" modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-deoxy-2'-fluoroadenosine, -guanosine, -uridine, and -cytidine,…”
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Allyl Group as a Protecting Group for Internucleotide Phosphate and Thiophosphate Linkages in Oligonucleotide Synthesis:  Facile Oxidation and Deprotection Conditions by Manoharan, Muthiah, Lu, Yixin, Casper, Martin D, Just, George

“…The allyl group, which serves as a protecting group for an internucleotide bond for both phosphates and phosphorothioates, can be easily removed by good…”
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Weaning From Mechanical Ventilation in Skilled Nursing Facility: A Multicenter Study by Ferrer, Gustavo, MD, Vallejo, Ivan, RT, Casper, Martin

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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT2A inverse-agonists and their application as antiplatelet agents by DOSA, Peter I, STRAH-PLEYNET, Sonja, WEBB, Robert R, ADAMS, John W, RAMIREZ, Juan, RICHMAN, Jeremy G, THOMSEN, William, SEMPLE, Graeme, TEEGARDEN, Bradley R, JAYAKUMAR, Honnappa, CASPER, Martin, DECAIRE, Marc, YIFENG XIONG, LEHMANN, Juerg, CHOI, Karoline, ELWELL, Katie, WONG, Amy

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Discovery and Structure−Activity Relationship of 3-Methoxy- N -(3-(1-methyl-1 H -pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine 2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis by Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien

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Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1 by Kanuma, Kosuke, Omodera, Katsunori, Nishiguchi, Mariko, Funakoshi, Takeo, Chaki, Shigeyuki, Semple, Graeme, Tran, Thuy-Anh, Kramer, Bryan, Hsu, Debbie, Casper, Martin, Thomsen, Bill, Sekiguchi, Yoshinori

“…The synthesis and SAR of 4-(dimethylamino)quinazolines as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists are reported, leading to the discovery…”
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT sub(2A) inverse-agonists and their application as antiplatelet agents by Dosa, Peter I, Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R, Adams, John W, Ramirez, Juan, Richman, Jeremy G, Thomsen, William, Semple, Graeme, Teegarden, Bradley R

“…Potent 5-HT sub(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in…”
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Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1 by Kanuma, Kosuke, Omodera, Katsunori, Nishiguchi, Mariko, Funakoshi, Takeo, Chaki, Shigeyuki, Semple, Graeme, Tran, Thuy-Anh, Kramer, Bryan, Hsu, Debbie, Casper, Martin, Thomsen, Bill, Beeley, Nigel, Sekiguchi, Yoshinori

“…High-throughput screening of our in-house GPCR-directed library uncovered a series of 4-(dimethylamino)quinazolines as melanin-concentrating hormone receptor 1…”
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT 2A inverse-agonists and their application as antiplatelet agents by Dosa, Peter I., Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R., Adams, John W., Ramirez, Juan, Richman, Jeremy G., Thomsen, William, Semple, Graeme, Teegarden, Bradley R.

“…Potent 5-HT 2A inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective…”
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents by Dosa, Peter I, Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R, Adams, John W, Ramirez, Juan, Richman, Jeremy G, Thomsen, William, Semple, Graeme, Teegarden, Bradley R

“…Potent 5-HT(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective…”
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Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl ( 2′-O-AOE) modified oligonucleotides by Kawasaki, Andrew M., Casper, Martin D., Prakash, Thazha P., Manalili, Sheri, Sasmor, Henri, Manoharan, Muthiah, Cook, P.Dan

“…The novel RNA mimic 2′-O-AOE has been incorporated into antisense oligonucleotides. This 2′-O-modification significantly enhances hybridization against target…”
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