Search Results - "CASE, Casey C"

Large animal and primate models of spinal cord injury for the testing of novel therapies by Kwon, Brian K., Streijger, Femke, Hill, Caitlin E., Anderson, Aileen J., Bacon, Mark, Beattie, Michael S., Blesch, Armin, Bradbury, Elizabeth J., Brown, Arthur, Bresnahan, Jacqueline C., Case, Casey C., Colburn, Raymond W., David, Samuel, Fawcett, James W., Ferguson, Adam R., Fischer, Itzhak, Floyd, Candace L., Gensel, John C., Houle, John D., Jakeman, Lyn B., Jeffery, Nick D., Jones, Linda Ann Truett, Kleitman, Naomi, Kocsis, Jeffery, Lu, Paul, Magnuson, David S.K., Marsala, Martin, Moore, Simon W., Mothe, Andrea J., Oudega, Martin, Plant, Giles W., Rabchevsky, Alexander Sasha, Schwab, Jan M., Silver, Jerry, Steward, Oswald, Xu, Xiao-Ming, Guest, James D., Tetzlaff, Wolfram

“…Large animal and primate models of spinal cord injury (SCI) are being increasingly utilized for the testing of novel therapies. While these represent…”
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Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia by Tate, Ciara C, Fonck, Carlos, McGrogan, Michael, Case, Casey C

“…Cell transplantation is a promising treatment strategy for many neurological disorders, including stroke, which can target multiple therapeutic mechanisms in a…”
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Gene-Specific Targeting of H3K9 Methylation Is Sufficient for Initiating Repression In Vivo by Snowden, Andrew W, Gregory, Philip D, Case, Casey C, Pabo, Carl O

“…Covalent modifications of chromatin have emerged as key determinants of the genome's transcriptional competence [1–3]. Histone H3 lysine 9 (H3K9) methylation…”
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Comparing the angiogenic potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells by Dao, Mo, Tate, Ciara C, McGrogan, Michael, Case, Casey C

“…Angiogenesis is a critical part of the endogenous repair process in brain injury and disease, and requires at least two sequential steps. First, angiogenic…”
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Induction of angiogenesis in a mouse model using engineered transcription factors by Giordano, Frank J, Rebar, Edward J, Huang, Yan, Hickey, Reed, Nath, Anjali K, Meoli, David, Nath, Sameer, Chen, Bingliang, Xu, Lei, Liang, Yuxin, Jamieson, Andrew C, Zhang, Lei, Spratt, S Kaye, Case, Casey C, Wolffe, Alan

“…The relationship between the structure of zinc-finger protein (ZFP) transcription factors and DNA sequence binding specificity has been extensively studied…”
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Mesenchymal stromal SB623 cell implantation mitigates nigrostriatal dopaminergic damage in a mouse model of Parkinson's disease by Tate, Ciara C., Chou, Vivian P., Campos, Carla, Moalem, Alimohammed S., Di Monte, Donato A., McGrogan, Michael, Case, Casey C., Manning‐Bog, Amy B.

“…Regenerative medicine for the treatment of motor features in Parkinson's disease (PD) is a promising therapeutic option. Donor cells can simultaneously address…”
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Comparison of the neuropoietic activity of gene-modified versus parental mesenchymal stromal cells and the identification of soluble and extracellular matrix-related neuropoietic mediators by Aizman, Irina, Tirumalashetty, Brenna J, McGrogan, Michael, Case, Casey C

“…Transplanting mesenchymal stromal cells (MSCs) or their derivatives into a neurodegenerative environment is believed to be beneficial because of the trophic…”
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Validated Zinc Finger Protein Designs for All 16 GNN DNA Triplet Targets by Liu, Qiang, Xia, ZhenQin, Case, Casey C.

“…The Cys2-His2-type zinc finger DNA-binding proteins can be engineered to bind specifically to many different DNA sequences. A single zinc finger typically…”
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Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells by Dao, Mo A, Tate, Ciara C, Aizman, Irina, McGrogan, Michael, Case, Casey C

“…SB623 cells are expanded from marrow stromal cells (MSCs) transfected with a Notch intracellular domain (NICD)-expressing plasmid. In stroke-induced animals,…”
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A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart by Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J

“…Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists…”
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Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy by PRICE, Sally A, DENT, Carolyn, TOMLINSON, David R, DURAN-JIMENEZ, Beatriz, YUXIN LIANG, LEI ZHANG, REBAR, Edward J, CASE, Casey C, GREGORY, Philip D, MARTIN, Tyler J, KAYE SPRATT, S

“…Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy Sally A. Price 1 , Carolyn…”
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Immune responses and long‐term disease recurrence status after telomerase‐based dendritic cell immunotherapy in patients with acute myeloid leukemia by Khoury, Hanna J., Collins, Robert H., Blum, William, Stiff, Patrick S., Elias, Laurence, Lebkowski, Jane S., Reddy, Anita, Nishimoto, Kevin P., Sen, Debasish, Wirth, Edward D., Case, Casey C., DiPersio, John F.

“…BACKGROUND Telomerase activity in leukemic blasts frequently is increased among patients with high‐risk acute myeloid leukemia (AML). In the current study, the…”
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Extracellular matrix produced by bone marrow stromal cells and by their derivative, SB623 cells, supports neural cell growth by Aizman, Irina, Tate, Ciara C., McGrogan, Michael, Case, Casey C.

“…Several studies have shown the benefits of transplanting bone marrow‐derived multipotent mesenchymal stromal cells (MSC) into neurodegenerative lesions of the…”
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Activation of Vascular Endothelial Growth Factor A Transcription in Tumorigenic Glioblastoma Cell Lines by an Enhancer with Cell Type-specific DNase I Accessibility by Liang, Yuxin, Li, Xiao-Yong, Rebar, Edward J., Li, Peixiang, Zhou, Yuanyue, Chen, Bingliang, Wolffe, Alan P., Case, Casey C.

“…Unregulated expression of vascular endothelial growth factor-A (VEGF-A) plays an important role in tumor growth. We have identified a cell type-specific…”
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Quantitative Microplate Assay for Studying Mesenchymal Stromal Cell‐Induced Neuropoiesis by Aizman, Irina, McGrogan, Michael, Case, Casey C.

“…This study characterizes a microplate‐format coculture system in which primary embryonic rat cortex cells were directly cocultured with human mesenchymal…”
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Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors by Liu, Pei-Qi, Tan, Siyuan, Mendel, Matthew C, Murrills, Richard J, Bhat, Bheem M, Schlag, Brian, Samuel, Rachelle, Matteo, Jeanne J, de la Rosa, Ragan, Howes, Katherine, Reik, Andreas, Case, Casey C, Bex, Frederick J, Young, Kathleen, Gregory, Philip D

“…Isogenic cell lines differing only in the expression of the protein of interest provide the ideal platform for cell-based screening. However, related natural…”
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Zinc-Finger Protein-Targeted Gene Regulation: Genomewide Single-Gene Specificity by Tan, Siyuan, Guschin, Dmitry, Davalos, Albert, Lee, Ya-Li, Snowden, Andrew W., Jouvenot, Yann, Zhang, H. Steven, Howes, Katherine, McNamara, Andrew R., Lai, Albert, Ullman, Chris, Reynolds, Lindsey, Moore, Michael, Isalan, Mark, Berg, Lutz-Peter, Campos, Bradley, Qi, Hong, Spratt, S. Kaye, Case, Casey C., Pabo, Carl O., Campisi, Judith, Gregory, Philip D.

“…Zinc-finger protein transcription factors (ZFP TFs) can be designed to control the expression of any desired target gene, and thus provide potential…”
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Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia by Dai, Qunsheng, Huang, Jianhua, Klitzman, Bruce, Dong, Chunming, Goldschmidt-Clermont, Pascal J, March, Keith L, Rokovich, Joseph, Johnstone, Brian, Rebar, Edward J, Spratt, S Kaye, Case, Casey C, Kontos, Christopher D, Annex, Brian H

“…Therapeutic angiogenesis seeks to promote blood vessel growth to improve tissue perfusion. Vascular endothelial growth factor (VEGF) exists in multiple…”
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Engineered Zinc Finger Proteins for Controlling Stem Cell Fate by Bartsevich, Victor V., Miller, Jeffrey C., Case, Casey C., Pabo, Carl O.

“…Stem cells are functionally defined as progenitor cells that can self‐renew and differentiate. Critical transitions in these cells are controlled via signaling…”
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Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors by SNOWDEN, Andrew W, LEI ZHANG, CASE, Casey C, PABO, Carl O, WOLFFE, Alan P, GREGORY, Philip D, URNOV, Fyodor, DENT, Carolyn, JOUVENOT, Yann, XIAOHONG ZHONG, REBAR, Edward J, JAMIESON, Andrew C, ZHANG, H. Steven, SIYUAN TAN

“…Angiogenic factors are necessary for tumor proliferation and thus are attractive therapeutic targets. In this study, we have used engineered zinc finger…”
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