Search Results - "CASANOVAS, Oriol"

Unraveling the Role of Angiogenesis in Cancer Ecosystems by Zuazo-Gaztelu, Iratxe, Casanovas, Oriol

“…Activation of the tumor and stromal cell-driven angiogenic program is one of the first requirements in the tumor ecosystem for growth and dissemination. The…”
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Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility by Angulo-Urarte, Ana, Casado, Pedro, Castillo, Sandra D., Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana M., Castel, Pau, Rajeeve, Vinothini, Milà-Guasch, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laia, Casanovas, Oriol, Viñals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R., Graupera, Mariona

“…Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are…”
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Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients by Jiménez-Valerio, Gabriela, Martínez-Lozano, Mar, Bassani, Nicklas, Vidal, August, Ochoa-de-Olza, María, Suárez, Cristina, García-del-Muro, Xavier, Carles, Joan, Viñals, Francesc, Graupera, Mariona, Indraccolo, Stefano, Casanovas, Oriol

“…Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily…”
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Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis by Pàez-Ribes, Marta, Allen, Elizabeth, Hudock, James, Takeda, Takaaki, Okuyama, Hiroaki, Viñals, Francesc, Inoue, Masahiro, Bergers, Gabriele, Hanahan, Douglas, Casanovas, Oriol

“…Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that…”
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PTEN mediates Notch-dependent stalk cell arrest in angiogenesis by Serra, Helena, Chivite, Iñigo, Angulo-Urarte, Ana, Soler, Adriana, Sutherland, James D., Arruabarrena-Aristorena, Amaia, Ragab, Anan, Lim, Radiance, Malumbres, Marcos, Fruttiger, Marcus, Potente, Michael, Serrano, Manuel, Fabra, Àngels, Viñals, Francesc, Casanovas, Oriol, Pandolfi, Pier Paolo, Bigas, Anna, Carracedo, Arkaitz, Gerhardt, Holger, Graupera, Mariona

“…Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in…”
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ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation by Alsina-Sanchís, Elisenda, García-Ibáñez, Yaiza, Figueiredo, Ana M, Riera-Domingo, Carla, Figueras, Agnès, Matias-Guiu, Xavier, Casanovas, Oriol, Botella, Luisa M, Pujana, Miquel A, Riera-Mestre, Antoni, Graupera, Mariona, Viñals, Francesc

“…OBJECTIVE—ALK1 (activin-receptor like kinase 1) is an endothelial cell-restricted receptor with high affinity for BMP (bone morphogenetic protein) 9 TGF-β…”
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Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors by Casanovas, Oriol, Hicklin, Daniel J., Bergers, Gabriele, Hanahan, Douglas

“…Function-blocking antibodies to VEGF receptors R1 and R2 were used to probe their roles in controlling angiogenesis in a mouse model of pancreatic islet…”
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Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice by Maione, Federica, Capano, Stefania, Regano, Donatella, Zentilin, Lorena, Giacca, Mauro, Casanovas, Oriol, Bussolino, Federico, Serini, Guido, Giraudo, Enrico

“…Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to…”
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The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels by Alsina‐Sanchis, Elisenda, Figueras, Agnès, Lahiguera, Álvaro, Vidal, August, Casanovas, Oriol, Graupera, Mariona, Villanueva, Alberto, Viñals, Francesc

“…In a search for new therapeutic targets for treating epithelial ovarian cancer, we analyzed the Transforming Growth Factor Beta (TGFβ) signaling pathway in…”
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Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain by Urrutia, Inés, Martín-Nieto, Alicia, Martínez, Rosa, Casanovas-Marsal, J Oriol, Aguayo, Anibal, del Olmo, Juan, Arana, Eunate, Fernandez-Rubio, Elsa, Castaño, Luis, Gaztambide, Sonia

“…The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an…”
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TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence by Puig, Isabel, Tenbaum, Stephan P, Chicote, Irene, Arqués, Oriol, Martínez-Quintanilla, Jordi, Cuesta-Borrás, Estefania, Ramírez, Lorena, Gonzalo, Pilar, Soto, Atenea, Aguilar, Susana, Eguizabal, Cristina, Caratù, Ginevra, Prat, Aleix, Argilés, Guillem, Landolfi, Stefania, Casanovas, Oriol, Serra, Violeta, Villanueva, Alberto, Arroyo, Alicia G, Terracciano, Luigi, Nuciforo, Paolo, Seoane, Joan, Recio, Juan A, Vivancos, Ana, Dienstmann, Rodrigo, Tabernero, Josep, Palmer, Héctor G

“…Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant…”
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Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents by Zuazo-Gaztelu, Iratxe, Pàez-Ribes, Marta, Carrasco, Patricia, Martín, Laura, Soler, Adriana, Martínez-Lozano, Mar, Pons, Roser, Llena, Judith, Palomero, Luis, Graupera, Mariona, Casanovas, Oriol

“…One of the main consequences of inhibition of neovessel growth and vessel pruning produced by angiogenesis inhibitors is increased intratumor hypoxia. Growing…”
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Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors by Soler, Adriana, Figueiredo, Ana M, Castel, Pau, Martin, Laura, Monelli, Erika, Angulo-Urarte, Ana, Milà-Guasch, Maria, Viñals, Francesc, Baselga, Jose, Casanovas, Oriol, Graupera, Mariona

“…Mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an exciting…”
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis by Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S, Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart

“…Understanding the direct, tumor cell-intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer…”
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Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing by Melo, Sonia, Villanueva, Alberto, Moutinho, Catia, Davalos, Veronica, Spizzo, Riccardo, Ivan, Cristina, Rossi, Simona, Setien, Fernando, Casanovas, Oriol, Simo-Riudalbas, Laia, Carmona, Javier, Carrere, Jordi, Vidal, August, Aytes, Alvaro, Puertas, Sara, Ropero, Santiago, Kalluri, Raghu, Croce, Carlo M, Calin, George A, Esteller, Manel

“…MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways. The…”
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Neoadjuvant sunitinib plus exemestane in post-menopausal women with hormone receptor-positive/HER2-negative early-stage breast cancer (SUT_EXE-08): a phase I/II trial by Fullana, Bartomeu, Morales, Serafín, Petit, Anna, Alay, Ania, Verdaguer, Helena, Climent, Fina, Navarro-Perez, Valentí, Cejuela, Mónica, Galvan, Patricia, Gumà, Anna, Llombart-Cussac, Antonio, Cordero, David, Casanovas, Oriol, Prat, Aleix, Gil-Gil, Miguel, Pernas, Sonia

“…Neoadjuvant endocrine therapy (NET) for hormone receptor-positive (HR+) breast cancer might be as effective as chemotherapy, with a better toxicity profile…”
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A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination by Figueras, Agnès, Alsina-Sanchís, Elisenda, Lahiguera, Álvaro, Abreu, Manuel, Muinelo-Romay, Laura, Moreno-Bueno, Gema, Casanovas, Oriol, Graupera, Mariona, Matias-Guiu, Xavier, Vidal, August, Villanueva, Alberto, Viñals, Francesc

“…Epithelial ovarian cancer is characterized by a low recovery rate because the disease is typically diagnosed at an advanced stage, by which time most patients…”
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Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research by Jiménez-Valerio, Gabriela, Casanovas, Oriol

“…The mechanisms of tumor growth and progression involve the activation of different processes such as neovascularization and angiogenesis. These processes…”
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Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination by Anderberg, Charlotte, Cunha, Sara I, Zhai, Zhenhua, Cortez, Eliane, Pardali, Evangelia, Johnson, Jill R, Franco, Marcela, Páez-Ribes, Marta, Cordiner, Ross, Fuxe, Jonas, Johansson, Bengt R, Goumans, Marie-José, Casanovas, Oriol, ten Dijke, Peter, Arthur, Helen M, Pietras, Kristian

“…Therapy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in cancer patients. We investigated the long-term…”
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Sunitinib Inhibits Tumor Growth and Synergizes with Cisplatin in Orthotopic Models of Cisplatin-Sensitive and Cisplatin-Resistant Human Testicular Germ Cell Tumors by CASTILLO-AVILA, Wilmar, PIULATS, Josep Maria, VINALS, Francesc, GARCIA DEL MURO, Xavier, VIDAL, August, CONDOM, Enric, CASANOVAS, Oriol, MORA, Josefina, RAMON GERMA, Josep, CAPELLA, Gabriel, VILLANUEVA, Alberto

“…Purpose: Germ cell tumors (GCT) of the testis are highly curable, but those patients who are refractory to cisplatin (CDDP)-based combination chemotherapy have…”
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