Search Results - "CARVALHO, Luzia H"

A Novel Erythrocyte Binding Protein of Plasmodium vivax Suggests an Alternate Invasion Pathway into Duffy-Positive Reticulocytes by Ntumngia, Francis B, Thomson-Luque, Richard, Torres, Letícia de Menezes, Gunalan, Karthigayan, Carvalho, Luzia H, Adams, John H

“…Erythrocyte invasion by malaria parasites is essential for blood-stage development and an important determinant of host range. In Plasmodium vivax, the…”
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Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region by Pires, Camilla V, Alves, Jessica R S, Lima, Barbara A S, Paula, Ruth B, Costa, Helena L, Torres, Leticia M, Sousa, Taís N, Soares, Irene S, Sanchez, Bruno A M, Fontes, Cor J F, Ntumngia, Francis B, Adams, John H, Kano, Flora S, Carvalho, Luzia H

“…Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even…”
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Antibody response to a new member of the DBL family (EBP2) after a brief Plasmodium vivax exposure by Lima, Bárbara A S, Fernandes, Gabriela M, Torres, Letícia M, Pires, Camilla V, Alves, Jéssica R S, Moreira-Nascimento, Sâmick L, Nascimento, Maria Fernanda A, Afonso, Sofia L, Costa, Helena L, Cerávolo, Isabela P, Sousa, Tais N, Soares, Irene S, Ntumngia, Francis B, Adams, John H, Carvalho, Luzia H, Kano, Flora S

“…Plasmodium vivax blood-stage invasion into reticulocyte is critical for parasite development. Thus, validation of novel parasite invasion ligands is essential…”
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Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response by Dias, Michelle H. F., Guimarães, Luiz F. F., Barcelos, Matheus G., Moreira, Eduardo U. M., do Nascimento, Maria F. A., de Souza, Taís N., Pires, Camilla V., Monteiro, Talita A. F., Middeldorp, Jaap M., Soares, Irene S., Fontes, Cor J. F., Ntumngia, Francis B., Adams, John H., Kano, Flora S., Carvalho, Luzia H.

“…BACKGROUNDThe simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's…”
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Augmented plasma microparticles during acute Plasmodium vivax infection by Campos, Fernanda M F, Franklin, Bernardo S, Teixeira-Carvalho, Andréa, Filho, Agnaldo L S, de Paula, Sálua C O, Fontes, Cor J, Brito, Cristiana F, Carvalho, Luzia H

“…In the last few years, the study of microparticles (MPs)--submicron vesicles released from cells upon activation or apoptosis--has gained growing interest in…”
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Multiplexed Microsphere-Based Flow Cytometric Assay to Assess Strain Transcending Antibodies to Plasmodium vivax Duffy Binding Protein II Reveals an Efficient Tool to Identify Binding-Inhibitory Antibody Responders by Alves, Jéssica R S, de Araújo, Fernanda F, Pires, Camilla V, Teixeira-Carvalho, Andréa, Lima, Barbara A S, Torres, Letícia M, Ntumngia, Francis B, Adams, John H, Kano, Flora S, Carvalho, Luzia H

“…Malaria remains a major public health problem worldwide, and is the most widely distributed malaria parasite. Naturally acquired binding inhibitory antibodies…”
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The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia by Santos, Marina L S, Coimbra, Roney S, Sousa, Tais N, Guimarães, Luiz F F, Gomes, Matheus S, Amaral, Laurence R, Pereira, Dhelio B, Fontes, Cor J F, Hawwari, Ibrahim, Franklin, Bernardo S, Carvalho, Luzia H

“…Severe thrombocytopenia can be a determinant factor in the morbidity of , the most widespread human malaria parasite. Although immune mechanisms may drive…”
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Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax by Cassiano, Gustavo C, Furini, Adriana A C, Capobianco, Marcela P, Storti-Melo, Luciane M, Cunha, Maristela G, Kano, Flora S, Carvalho, Luzia H, Soares, Irene S, Santos, Sidney E, Póvoa, Marinete M, Machado, Ricardo L D

“…The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has…”
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Duffy antigen receptor for chemokine (DARC) polymorphisms and its involvement in acquisition of inhibitory anti-duffy binding protein II (DBPII) immunity by Souza-Silva, Flávia A, Torres, Letícia M, Santos-Alves, Jessica R, Tang, Michaelis Loren, Sanchez, Bruno A M, Sousa, Tais N, Fontes, Cor J F, Nogueira, Paulo A, Rocha, Roberto S, Brito, Cristiana F A, Adams, John H, Kano, Flora S, Carvalho, Luzia H

“…The Plasmodium vivax Duffy binding protein (PvDBP) and its erythrocytic receptor, the Duffy antigen receptor for chemokines (DARC), are involved in the major…”
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Plasma circulating nucleic acids levels increase according to the morbidity of Plasmodium vivax malaria by Franklin, Bernardo S, Vitorino, Barbara L F, Coelho, Helena C, Menezes-Neto, Armando, Santos, Marina L S, Campos, Fernanda M F, Brito, Cristiana F, Fontes, Cor J, Lacerda, Marcus V, Carvalho, Luzia H

“…Given the increasing evidence of Plasmodium vivax infections associated with severe and fatal disease, the identification of sensitive and reliable markers for…”
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Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations by Sousa, Taís N, Tarazona-Santos, Eduardo M, Wilson, Daniel J, Madureira, Ana P, Falcão, Paula R K, Fontes, Cor J F, Gil, Luiz H S, Ferreira, Marcelo U, Carvalho, Luzia H, Brito, Cristiana F A

“…Plasmodium vivax malaria is a major public health challenge in Latin America, Asia and Oceania, with 130-435 million clinical cases per year worldwide…”
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Short-Term Antigen Presentation and Single Clonal Burst Limit the Magnitude of the CD8+ T Cell Responses to Malaria Liver Stages by Julius C. R. Hafalla, Sano, Gen-ichiro, Carvalho, Luzia H., Morrot, Alexandre, Zavala, Fidel

“…Malaria sporozoites induce swift activation of antigen-specific CD8+ T cells that inhibit the intracellular development of liver-stage parasites. The length of…”
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Improving N-terminal protein annotation of Plasmodium species based on signal peptide prediction of orthologous proteins by Neto, Armando de Menezes, Alvarenga, Denise A, Rezende, Antônio M, Resende, Sarah S, Ribeiro, Ricardo de Souza, Fontes, Cor J F, Carvalho, Luzia H, de Brito, Cristiana F Alves

“…Signal peptide is one of the most important motifs involved in protein trafficking and it ultimately influences protein function. Considering the expected…”
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Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? by Souza-Neiras, Wanessa C, Storti-Melo, Luciane M, Cassiano, Gustavo C, Couto, Vanja S C A, Couto, Alvaro A R A, Soares, Irene S, Carvalho, Luzia H, Cunha, Maristela G, Póvoa, Marinete M, Herrera, Socrates, Herrera, Myriam A, Rossit, Andrea R M, Carareto, Claudia M A, Machado, Ricardo L D

“…Plasmodium vivax circumsporozoite variants have been identified in several geographical areas. The real implication of the genetic variation in this region of…”
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Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA by Gnidehou, Sédami, Mitran, Catherine J, Arango, Eliana, Banman, Shanna, Mena, Angie, Medawar, Evelyn, Lima, Barbara A S, Doritchamou, Justin, Rajwani, Jahanara, Jin, Albert, Gavina, Kenneth, Ntumngia, Francis, Duffy, Patrick, Narum, David, Ndam, Nicaise Tuikue, Nielsen, Morten A, Salanti, Ali, Kano, Flora S, Carvalho, Luzia H, Adams, John H, Maestre, Amanda, Good, Michael F, Yanow, Stephanie K

“…Antibodies to Plasmodium falciparum VAR2CSA, a critical antigen that mediates placental malaria, can be acquired outside of pregnancy. Here we show that…”
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Natural genetic diversity of the DBL domain of a novel member of the Plasmodium vivax erythrocyte binding-like proteins (EBP2) in the Amazon rainforest by Fernandes, Gabriela M., Rodrigues-Mattos, Guilherme H., Torres, Letícia M., Guedes, Karla S., Fontes, Cor J.F., Ntumngia, Francis B., Adams, John H., Brito, Cristiana F.A., Kano, Flora S., de Sousa, Taís N., Carvalho, Luzia H.

“…In malaria parasites, the erythrocyte binding-like proteins (EBL) are a family of invasion proteins that are attractive vaccine targets. In the case of…”
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An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies by Ntumngia, Francis B., Pires, Camilla V., Barnes, Samantha J., George, Miriam T., Thomson-Luque, Richard, Kano, Flora S., Alves, Jessica R. S., Urusova, Darya, Pereira, Dhelio B., Tolia, Niraj H., King, Christopher L., Carvalho, Luzia H., Adams, John H.

“…Plasmodium vivax invasion into human reticulocytes is a complex process. The Duffy binding protein (DBP) dimerization with its cognate receptor is vital for…”
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Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA by Mitran, Catherine J, Mena, Angie, Gnidehou, Sedami, Banman, Shanna, Arango, Eliana, Lima, Barbara A S, Lugo, Hazel, Ganesan, Aravindhan, Salanti, Ali, Mbonye, Anthony K, Ntumngia, Francis, Barakat, Khaled, Adams, John H, Kano, Flora S, Carvalho, Luzia H, Maestre, Amanda E, Good, Michael F, Yanow, Stephanie K

“…Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host…”
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Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period by Medeiros, Camila M P, Moreira, Eduardo U M, Pires, Camilla V, Torres, Letícia M, Guimarães, Luiz F F, Alves, Jéssica R S, Lima, Bárbara A S, Fontes, Cor J F, Costa, Helena L, Brito, Cristiana F A, Sousa, Tais N, Ntumngia, Francis B, Adams, John H, Kano, Flora S, Carvalho, Luzia H

“…A low proportion of P. vivax-exposed individuals acquire protective strain-transcending neutralizing IgG antibodies that are able to block the interaction…”
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Contribution of inflammasome genetics in Plasmodium vivax malaria by Santos, Marina L.S., Reis, Edione Cristina, Bricher, Pamela N., Sousa, Tais N., Brito, Cristiana F.A., Lacerda, Marcus V.G., Fontes, Cor J.F., Carvalho, Luzia H., Pontillo, Alessandra

“…Recent reports showed that, in mice, symptomatic Plasmodium infection triggers NLRP3/NLRP12-dependent inflammasome formation and caspase-1 activation in…”
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