Search Results - "CARVALHO, F. S"

Anticancer steroids: linking natural and semi-synthetic compounds by Salvador, Jorge A R, Carvalho, João F S, Neves, Marco A C, Silvestre, Samuel M, Leitão, Alcino J, Silva, M Manuel C, Sá e Melo, M Luisa

“…Steroids, a widespread class of natural organic compounds occurring in animals, plants and fungi, have shown great therapeutic value for a broad array of…”
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Targeting homologous recombination-mediated DNA repair in cancer by Carvalho, João F S, Kanaar, Roland

“…DNA is the target of many traditional non-specific chemotherapeutic drugs. New drugs or therapeutic approaches with a more rational and targeted component are…”
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Differences in DNA methylation status explain phenotypic variability in patients with 5p- syndrome by Almeida, Vanessa Tavares, Chehimi, Samar N, Carvalho, Gleyson F S, Gasparini, Yanca, Nascimento, Amom M, Vieira, Lucas L, Wolff, Beatriz M, Montenegro, Marília M, Kulikowski, Leslie D

“…Cri Du Chat syndrome, or 5p- syndrome, is characterized by a terminal or interstitial deletion on the short arm of chromosome 5 that causes variable clinical…”
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Removal of Human Ether-à-go-go Related Gene (hERG) K+ Channel Affinity through Rigidity: A Case of Clofilium Analogues by Louvel, Julien, Carvalho, João F. S, Yu, Zhiyi, Soethoudt, Marjolein, Lenselink, Eelke B, Klaasse, Elisabeth, Brussee, Johannes, IJzerman, Adriaan P

“…Cardiotoxicity is a side effect that plagues modern drug design and is very often due to the off-target blockade of the human ether-à-go-go related gene…”
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Mast cell survival and mediator secretion in response to hypoxia by Gulliksson, Magdalena, Carvalho, Ricardo F S, Ullerås, Erik, Nilsson, Gunnar

“…Tissue hypoxia is a consequence of decreased oxygen levels in different inflammatory conditions, many associated with mast cell activation. However, the effect…”
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Aluminum-to-Steel Cladding by Explosive Welding by H. S. F. L. Carvalho, Gustavo, Galvão, Ivan, Mendes, Ricardo, M. Leal, Rui, Loureiro, Altino

“…The production of aluminum-carbon steel and aluminum-stainless steel clads is challenging, and explosive welding is one of the most suitable processes to…”
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Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon‐γ and interleukin‐10 and low frequency of tumour necrosis factor‐α+ monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection by Peruhype‐Magalhães, V., Martins‐Filho, O. A., Prata, A., Silva, L. De A., Rabello, A., Teixeira‐Carvalho, A., Figueiredo, R. M., Guimarães‐Carvalho, S. F., Ferrari, T. C. A., Van Weyenbergh, J., Correa‐Oliveira, R.

“…Summary Considering the complexity of the immunological events triggered during active visceral Leishmaniasis (VL), the relevance of the segregation of the…”
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Strategies To Reduce hERG K+ Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide by Carvalho, João F. S, Louvel, Julien, Doornbos, Maarten L. J, Klaasse, Elisabeth, Yu, Zhiyi, Brussee, Johannes, IJzerman, Adriaan P

“…Drug-induced blockade of the human ether-a-go-go-related gene K+ channel (hERG) represents one of the major antitarget concerns in pharmaceutical industry. SAR…”
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Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis by Carvalho, João F. S, Silva, M. Manuel Cruz, Moreira, João N, Simões, Sérgio, Sá e Melo, M. Luisa

“…The cytotoxicity of oxysterols was systematically studied in tumor and normal cells. Synthetic strategies to prepare this library included oxidations at ring B…”
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Perkinsus beihaiensis (Perkinsozoa) in oysters of Bahia State, Brazil by Luz, M S A, Carvalho, F S, Oliveira, H C, Boehs, G

“…This study reports the pathogen Perkinsus beihaiensis in oysters of the genus Crassostrea on the coast of the State of Bahia (Brazil), its prevalence,…”
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Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR by Carvalho, João F. S, Silva, M. Manuel Cruz, Moreira, João N, Simões, Sérgio, Sá e Melo, M. Luisa

“…Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against seven…”
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Agents causing genital infections in routine cytological tests: frequency and characteristics of Papanicolaou smears by Carvalho, F. S., Porto, N. K. A., Azevedo, P. V. M., Magalhães, P. K. A., Araújo, E. N. de, Correia, M. S., Silva, K. M. da, Pavão, J. M. S. J., Ferreira, J. R. da S., Maior, L. P. S., Cavalcanti, M. G. S., Ferreira-Júnior, G. C., Matos-Rocha, T. J.

“…Abstract Urinary tract infections are responsible for most human infections, these are caused by bacteria, fungi, protozoa and associated microorganisms. The…”
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Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients by Minin, Eduarda O Z, Paim, Layde R, Lopes, Elisangela C P, Bueno, Larissa C M, Carvalho-Romano, Luís F R S, Marques, Edmilson R, Vegian, Camila F L, Pio-Magalhães, José A, Coelho-Filho, Otavio R, Sposito, Andrei C, Matos-Souza, José R, Nadruz, Wilson, Schreiber, Roberto

“…Hypertension is a strong risk factor for atherosclerosis. Increased carotid intima-media thickness (cIMT) and carotid plaques are considered subclinical…”
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Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols by Carvalho, João F. S, Cruz Silva, M. Manuel, Moreira, João N, Simões, Sérgio, Sá e Melo, M. Luisa

“…A library of diastereomerically pure epoxysterols, prepared by combining chemical and enzymatic methodologies, was evaluated for cytotoxicity toward human…”
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Immune Response in Human Visceral Leishmaniasis: Analysis of the Correlation Between Innate Immunity Cytokine Profile and Disease Outcome by Peruhype‐Magalhães, V., Martins‐Filho, O. A., Prata, A., De A. Silva, L., Rabello, A., Teixeira‐Carvalho, A., Figueiredo, R. M., Guimarães‐Carvalho, S. F., Ferrari, T. C. A., Correa‐Oliveira, R.

“…We investigated the cytokine profile of cells of the innate immune response and its association with active (ACT), asymptomatic (AS) and cured (CUR) human…”
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Aspects of the Macroscopic Testicular and Epididymal Morphology in the Greater Rhea, Rhea Americana (Linneaus – 1758) Birds by Carvalho, S. F. M, Freneau, B. N, Frerneau, G. E

“…The purpose of this research was to study the macroscopic testicular and epididymal morphology of the greater rhea. The testicles of 54 greater rhea bred in…”
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Radial distribution function for liquid gallium from experimental structure factor: a Hopfield neural network approach by Carvalho, F. S., Braga, J. P.

“…Hopfield neural network was used to retrieve liquid gallium radial distribution function from an experimental structure factor, obtained at 959 K. The…”
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Aquatic pollutants are associated with reproductive alterations and genotoxicity in estuarine fish (Sciades herzbergii - Bloch, 1794) from the Amazon Equatorial Coast by Noleto, K S, Mendes, D C S, Carvalho, I F S, Ribeiro, D L S, Santos, D M S, Ferreira, A P M, Marques, A L B, Carvalho Neta, R N F, Tchaicka, L, Torres Júnior, J R S

“…Estuaries are constantly subject to continuous environmental impacts of human activities, such as fisheries, port or industry, and domestic sewage, with fish…”
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Indirect Solution of Ornstein-Zernike Equation Using the Hopfield Neural Network Method by Carvalho, F. S., Braga, J. P.

“…Microscopic information, such as the pair distribution and direct correlation functions, can be obtained from experimental data. From these correlation…”
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Reciprocating wear tests of Al-Si/SiCp composites: A study of the effect of stroke length by GOMES, J. R, RAMALHO, A, CASPAR, M. C, CARVALHO, S. F

“…The aim of the work described here was to find evidence for the influence of stroke length on the reciprocating wear of aluminium matrix composites. For this…”
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