Rapid increase in plasma levels of atrial natriuretic peptide after common bile duct ligation in the rabbit

Previous studies have shown that common bile duct ligation in the rabbit is followed by a reduction of the extracellular water compartment. To further elucidate the mechanisms leading to volume depletion in this model, water and sodium balances and changes in plasma concentrations of atrial natriure...

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Bibliographic Details
Published in:	Annals of surgery Vol. 216; no. 5; pp. 554 - 559
Main Authors:	VALVERDE, J, MARTINEZ-RODENAS, F, PEREIRA, J. A, CARULLA, XL, JIMENEZ, W, GUBERN, J. M, SITGES-SERRA, A
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott 01-11-1992
Subjects:	Acute Kidney Injury - etiology Aldosterone - blood Animals Atrial Natriuretic Factor - blood Biological and medical sciences Cholestasis - complications Common Bile Duct - surgery Ligation Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Natriuresis - physiology Rabbits Renin - blood Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Time Factors Vasopressins - blood Water-Electrolyte Balance - physiology Water-Electrolyte Imbalance - etiology Jaundice Ligature Animal Surgery Digestive diseases Exploration Atrial natriuretic peptide Experimental study Biliary tract disease
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Summary:	Previous studies have shown that common bile duct ligation in the rabbit is followed by a reduction of the extracellular water compartment. To further elucidate the mechanisms leading to volume depletion in this model, water and sodium balances and changes in plasma concentrations of atrial natriuretic peptide (ANP), vasopressin (ADH), plasma renin activity (PRA) and aldosterone (Ald) were investigated during the first 4 days after common bile duct ligation (group OJ,) or sham operation (group SO). Water and chow intakes were lower in group OJ (148 +/- 30 versus 226 +/- 40 mL/4 days; p = 0.004 and 12 +/- 9 versus 171 +/- 40 g/4 days; p = 0.0001). There were no differences in urine output. Sodium urinary losses were marginally higher in group OJ (12.4 +/- 7 versus 6.7 +/- 5 mEq/4 days; p = 0.06). Water balance was lower in group OJ (-50 +/- 56 versus 101 +/- 71 mL/4 days; p = 0.0001). At 24 hours, plasma ANP (41 +/- 7 versus 10.7 +/- 1 fmol/mL, p = 0.0001), ADH (21.8 +/- 7 versus 12.3 +/- 6 pg/mL, p = 0.008) and Ald (14.5 +/- 5 versus 3.7 +/- 3 ng/dL, p = 0.001) were higher in group OJ. These alterations persisted 72 hours after bile duct ligation, when a concomitant increase in PRA (10.7 +/- 5 versus 3 +/- 1.6 ng/dL, p = 0.006) was also observed. A group of pair-fed pair-watered sham-operated controls (group SO2, n = 13) showed a metabolic profile similar to group OJ but a low ANP concentration. Multiple venous sampling in five rabbits 24 hours after bile duct ligation showed the highest plasma levels of ANP in the aorta and infrarenal vena cava. These results suggest that common bile duct ligation in the rabbit is followed by marked hypodipsia and hypophagia, possibly mediated by ANP, leading to isotonic volume depletion and secondary activation of the water and sodium retaining hormones.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-4932 1528-1140
DOI:	10.1097/00000658-199211000-00005