Search Results - "CARTER, David S"

Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]­methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase by Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.

“…In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to…”
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Generic Norms, Irony, and Authenticity in the AABA Songs of the Rolling Stones, 1963–1971 by Carter, David S.

“…AABA form was in decline in popular music in the 1960s, yet the Rolling Stones made extensive use of it at a crucial point in their career. In this article I…”
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Rhodium(II)-Catalyzed Hinsberg Dearomatization Using Trimethylsilyldiazomethane by Combs, Jason R., Carter, David S., Gu, Fengyi, Jin, Xiaokang, Martin, Connor M., Resendiz, Elizabeth S., Van Vranken, David L.

“…Rhodium­(II) catalyzes carbene transfer from trimethylsilyldiazomethane to arylmethyl thioethers, generating sulfonium ylides that undergo [2,3]-sigmatropic…”
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Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis by Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A

“…A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found…”
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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates by Padilla, Angel M., Wang, Wei, Akama, Tsutomu, Carter, David S., Easom, Eric, Freund, Yvonne, Halladay, Jason S., Liu, Yang, Hamer, Sarah A., Hodo, Carolyn L., Wilkerson, Gregory K., Orr, Dylan, White, Brooke, George, Arlene, Shen, Huifeng, Jin, Yiru, Wang, Michael Zhuo, Tse, Susanna, Jacobs, Robert T., Tarleton, Rick L.

“…Trypanosoma cruzi , the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The…”
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Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model by Robertson, Gregory T, Ektnitphong, Victoria A, Scherman, Michael S, McNeil, Matthew B, Dennison, Devon, Korkegian, Aaron, Smith, Anthony J, Halladay, Jason, Carter, David S, Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, Alley, M R K, Parish, Tanya, Lenaerts, Anne J

“…AN12855 is a direct, cofactor-independent inhibitor of InhA in In the C3HeB/FeJ mouse model with caseous necrotic lung lesions, AN12855 proved efficacious with…”
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The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis by Korkegian, Aaron, O'Malley, Theresa, Xia, Yi, Zhou, Yasheen, Carter, David S., Sunde, Bjorn, Flint, Lindsay, Thompson, Dean, Ioerger, Thomas R., Sacchettini, Jim, Alley, M.R.K., Parish, Tanya

“…We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with…”
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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA by Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, Mrk

“…New antitubercular agents are needed to combat the spread of multidrug- and extensively drug-resistant strains of . The frontline antitubercular drug isoniazid…”
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Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs by Akama, Tsutomu, Freund, Yvonne R, Berry, Pamela W, Carter, David S, Easom, Eric E, Jarnagin, Kurt, Lunde, Christopher S, Plattner, Jacob J, Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A, Lim, Kee Chong, Suzuki, Brian M, Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W, McKerrow, James, Hübner, Marc P, Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A, Jacobs, Robert T

“…A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca…”
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Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain by Carter, David S, Alam, Muzaffar, Cai, Haiying, Dillon, Michael P, Ford, Anthony P D W, Gever, Joel R, Jahangir, Alam, Lin, Clara, Moore, Amy G, Wagner, Paul J, Zhai, Yansheng

“…P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X(3) and P2X(2/3) receptor subtypes have been shown to play an…”
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Palladium-catalyzed insertion reactions of trimethylsilyldiazomethane by Greenman, Kevin L, Carter, David S, Van Vranken, David L

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Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs by Carter, David S, Jacobs, Robert T, Freund, Yvonne R, Berry, Pamela W, Akama, Tsutomu, Easom, Eric E, Lunde, Christopher S, Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A, Lim, Kee Chong, Suzuki, Brian M, Tricoche, Nancy, Sakanari, Judy A, Lustigman, Sara, Plattner, Jacob J

“…The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a…”
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Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain by Jahangir, Alam, Alam, Muzaffar, Carter, David S, Dillon, Michael P, Bois, Daisy Joe Du, Ford, Anthony P D W, Gever, Joel R, Lin, Clara, Wagner, Paul J, Zhai, Yansheng, Zira, Jeff

“…The purinoceptor subtypes P2X(3) and P2X(2/3) have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and…”
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Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain by CARTER, David S, ALAM, Muzaffar, YANSHENG ZHAI, HAIYING CAI, DILLON, Michael P, FORD, Anthony P. D. W, GEVER, Joel R, JAHANGIR, Alam, LIN, Clara, MOORE, Amy G, WAGNER, Paul J

“…P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X3 and P2X2/3 receptor subtypes have been shown to play an important…”
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Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist by BROTHERTON-PLEISS, Christine E, DILLON, Michael P, YANSHENG ZHAI, FORD, Anthony P. D. W, GEVER, Joel R, CARTER, David S, GLEASON, Shelley K, LIN, Clara J, MOORE, Amy G, THOMPSON, Anthony W, VILLA, Marzia

“…Despite the extensive literature describing the role of the ATP-gated P2X(3) receptors in a variety of physiological processes the potential of antagonists as…”
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2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression by Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Iyer, Pravin S., Lucas, Matthew C., Roetz, Ralf, Schoenfeld, Ryan C., Weikert, Robert J.

“…The discovery and optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors is described. Recently a class of…”
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Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain by JAHANGIR, Alam, ALAM, Muzaffar, ZIRA, Jeff, CARTER, David S, DILLON, Michael P, BOIS, Daisy Joe Du, FORD, Anthony P. D. W, GEVER, Joel R, LIN, Clara, WAGNER, Paul J, YANSHENG ZHAI

“…The purinoceptor subtypes P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective…”
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Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain by Lucas, Matthew C., Weikert, Robert J., Carter, David S., Cai, Hai-Ying, Greenhouse, Robert, Iyer, Pravin S., Lin, Clara J., Lee, Eun Kyung, Madera, Ann Marie, Moore, Amy, Ozboya, Kerem, Schoenfeld, Ryan C., Steiner, Sandra, Zhai, Yansheng, Lynch, Stephen M.

“…Two new series of monoamine triple reuptake inhibitors (TRIs) have been discovered through scaffold homologation of our recently reported series of…”
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Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors by BANNWART, Linda M, CARTER, David S, LYNCH, Stephen M, MADERA, Ann Marie, MOORE, Amy, OZBOYA, Kerem, RAPTOVA, Lubica, ROETZ, Ralf, SCHOENFELD, Ryan C, STEIN, Karin Ann, STEINER, Sandra, VILLA, Marzia, CAI, Hai-Ying, WEIKERT, Robert J, YANSHENG ZHAI, CHOY, Jason C, GREENHOUSE, Robert, JAIME-FIGUEROA, Saul, LYER, Pravin S, LIN, Clara J, EUN KYUNG LEE, LUCAS, Matthew C

“…A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro…”
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Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors by Lucas, Matthew C., Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Schoenfeld, Ryan C., Steiner, Sandra, Villa, Marzia, Weikert, Robert J., Iyer, Pravin S.

“…A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main…”
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