Search Results - "CARSON, James A"

Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease by Carson, James A, Manolagas, Stavros C

“…Abstract Estrogens and androgens influence the growth and maintenance of bones and muscles and are responsible for their sexual dimorphism. A decline in their…”
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Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation by VanderVeen, Brandon N., Carson, James A., Fix, Dennis K.

“…Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical models. Cachexia is prevalent in roughly 80% of cancer patients and…”
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Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer by Bader, Jackie E, Enos, Reilly T, Velázquez, Kandy T, Carson, Meredith S, Nagarkatti, Mitzi, Nagarkatti, Prakash S, Chatzistamou, Ioulia, Davis, J Mark, Carson, James A, Robinson, Cory M, Murphy, E Angela

“…We examined the role of macrophages in inflammation associated with colorectal cancer (CRC). Given the emerging evidence on immune-microbiota interactions in…”
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The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia by VanderVeen, Brandon N, Murphy, E Angela, Carson, James A

“…Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a common comorbidity associated with cancer that results in adverse…”
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Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle by White, James P., Gao, Song, Puppa, Melissa J., Sato, Shuichi, Welle, Stephen L., Carson, James A.

“…► Testosterone loss suppresses myofibrillar protein synthesis and Akt/mTORC1 signaling. ► Testosterone loss activates muscle FoxO3a and its transcriptional…”
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Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK by White, James P, Puppa, Melissa J, Gao, Song, Sato, Shuichi, Welle, Stephen L, Carson, James A

“…Although catabolic signaling has a well-established role in muscle wasting during cancer cachexia, the suppression of anabolic signaling also warrants further…”
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The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse by White, James P, Baynes, John W, Welle, Stephen L, Kostek, Matthew C, Matesic, Lydia E, Sato, Shuichi, Carson, James A

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+) mouse is a…”
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Inflammation, physical activity, and chronic disease: An evolutionary perspective by Burini, Roberto Carlos, Anderson, Elizabeth, Durstine, J. Larry, Carson, James A.

“…Low-grade inflammation is emerging as a common feature of contemporary metabolic, psychiatric, and neurodegenerative diseases. Both physical inactivity and…”
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The Effect of Wheel Exercise on Functional Indices of Cachexia in Tumor-bearing Mice by VANDERVEEN, BRANDON N., FIX, DENNIS K., COUNTS, BRITTANY R., CARSON, JAMES A.

“…INTRODUCTIONCancer-related fatigue and muscle wasting have received significant attention over the last few decades with the goal of establishing interventions…”
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The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse by White, James P., Baynes, John W., Welle, Stephen L., Kostek, Matthew C., Matesic, Lydia E., Sato, Shuichi, Carson, James A.

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The ApcMin/+ mouse is a…”
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Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes by Guigni, Blas A, Fix, Dennis K, Bivona, 3rd, Joseph J, Palmer, Bradley M, Carson, James A, Toth, Michael J

“…Muscle contraction may protect against the effects of chemotherapy to cause skeletal muscle atrophy, but the mechanisms underlying these benefits are unclear…”
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Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity by Frizzell, Norma, Thomas, Sonia A, Carson, James A, Baynes, John W

“…2SC [S-(2-succino)-cysteine] is a chemical modification formed by a Michael addition reaction of fumarate with cysteine residues in proteins. Formation of 2SC,…”
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Eccentric contraction-induced myofiber growth in tumor-bearing mice by Hardee, Justin P, Mangum, Joshua E, Gao, Song, Sato, Shuichi, Hetzler, Kimbell L, Puppa, Melissa J, Fix, Dennis K, Carson, James A

“…Cancer cachexia is characterized by the progressive loss of skeletal muscle mass. While mouse skeletal muscle's response to an acute bout of stimulated…”
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Mitochondria transplant therapy improves regeneration and restoration of injured skeletal muscle by Alway, Stephen E., Paez, Hector G., Pitzer, Christopher R., Ferrandi, Peter J., Khan, Mohammad Moshahid, Mohamed, Junaith S., Carson, James A., Deschenes, Michael R.

“…Background Injection of exogenous mitochondria has been shown to improve the ischaemia‐damaged myocardium, but the effect of mitochondrial transplant therapy…”
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Recovery from FOLFOX chemotherapy-induced systemic and skeletal muscle metabolic dysfunction in mice by Halle, Jessica L, Counts, Brittany R, Paez, Hector G, Baumfalk, Dryden R, Zhang, Quan, Mohamed, Junaith S, Glazer, Evan S, Puppa, Melissa J, Smuder, Ashley J, Alway, Stephen E, Carson, James A

“…FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is used to treat colorectal cancer and can acutely induce metabolic dysfunction. However, the…”
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PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8+ T cells in breast cancer by Chaib, Mehdi, Sipe, Laura M., Yarbro, Johnathan R., Bohm, Margaret S., Counts, Brittany R., Tanveer, Ubaid, Pingili, Ajeeth K., Daria, Deidre, Marion, Tony N., Carson, James A., Thomas, Paul G., Makowski, Liza

“…Myeloid-derived suppressor cells (MDSCs) are an immature innate cell population that expands in pathological conditions such as cancer and suppresses T cells…”
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The Acute Effects of 5 Fluorouracil on Skeletal Muscle Resident and Infiltrating Immune Cells in Mice by VanderVeen, Brandon N, Sougiannis, Alexander T, Velazquez, Kandy T, Carson, James A, Fan, Daping, Murphy, E Angela

“…5 fluorouracil (5FU) has been a first-choice chemotherapy drug for several cancer types (e.g., colon, breast, head, and neck); however, its efficacy is…”
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Muscle oxidative capacity during IL-6-dependent cancer cachexia by White, James P, Baltgalvis, Kristen A, Puppa, Melissa J, Sato, Shuichi, Baynes, John W, Carson, James A

“…Many diseases are associated with catabolic conditions that induce skeletal muscle wasting. These various catabolic states may have similar and distinct…”
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Cachectic skeletal muscle response to a novel bout of low-frequency stimulation by Puppa, Melissa J, Murphy, E Angela, Fayad, Raja, Hand, Gregory A, Carson, James A

“…While exercise benefits have been well documented in patients with chronic diseases, the mechanistic understanding of cachectic muscle's response to…”
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Linking Cancer Cachexia-Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism by Hardee, Justin P., Carson, James A., Montalvo, Ryan N.

“…Cancer cachexia, a wasting syndrome characterized by skeletal muscle depletion, contributes to increased patient morbidity and mortality. While the intricate…”
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