Search Results - "CARSON, GERALD"

Early integration of Design of Experiment (DOE) and multivariate statistics identifies feeding regimens suitable for CHO cell line development and screening by Mora, Alessandro, Nabiswa, Bernard, Duan, Yuanyuan, Zhang, Sheng, Carson, Gerald, Yoon, Seongkyu

“…In Chinese Hamster Ovary (CHO) cell lines, the establishment of the ideal fed-batch regimen promotes metabolic conditions advantageous for the bioproduction of…”
Get full text

Expression of antibodies using single open reading frame (sORF) vector design: Demonstration of manufacturing feasibility by Gion, Wendy R., Davis-Taber, Rachel A., Regier, Dean A., Fung, Emma, Medina, Limary, Santora, Ling C., Bose, Sahana, Ivanov, Alexander V., Perilli-Palmer, Barbara A., Chumsae, Chris M., Matuck, Joseph G., Kunes, Yune Z., Carson, Gerald R.

“…Efficient production of large quantities of therapeutic antibodies is becoming a major goal of the pharmaceutical industry. We developed a proprietary…”
Get full text

Expression of antibodies using single-open reading frame vector design and polyprotein processing from mammalian cells by Kunes, Yune Z., Gion, Wendy R., Fung, Emma, Salfeld, Jochen G., Zhu, Rong-Rong, Sakorafas, Paul, Carson, Gerald R.

“…We describe a novel polyprotein precursor‐based approach to express antibodies from mammalian cells. Rather than expressing heavy and light chain proteins from…”
Get full text

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis by Weisman, Harlan F., Bartow, Thomas, Leppo, Michelle K., Marsh, Henry C., Carson, Gerald R., Concino, Michael F., Boyle, Michael P., Roux, Kenneth H., Weisfeldt, Myron L., Fearon, Douglas T.

“…The complement system is an important mediator of the acute inflammatory response, and an effective inhibitor would suppress tissue damage in many autoimmune…”
Get full text

The gel microdrop secretion assay : identification of a low productivity subpopulation arising during the production of human antibody in CHO cells by HAMMILL, Linda, WELLES, Jacqueline, CARSON, Gerald R

“…The long-term stability of high-level expression is the mostimportant factor to consider when choosing cell lines for the expression of recombinant proteins…”
Get full text

Sustaining an efficient and effective CHO cell line development platform by incorporation of 24‐deep well plate screening and multivariate analysis by Mora, Alessandro, Zhang, Sheng (Sam), Carson, Gerald, Nabiswa, Bernard, Hossler, Patrick, Yoon, Seongkyu

“…Efficient and effective cell line screening is paramount toward a successful biomanufacturing program. Here we describe the implementation of 24‐deep well…”
Get full text

Associations between Subunit Ectodomains Promote T Cell Antigen Receptor Assembly and Protect against Degradation in the ER by Wileman, Thomas, Kane, Lawrence P., Young, Juliana, Carson, Gerald R., Terhorst, Cox

“…The T cell antigen receptor (TCR) is an oligomeric protein complex made from at least six different integral membrane proteins (αβγδε and ζ). The TCR is…”
Get full text

Measurement of Proteolysis in Natural Waters by Little, J E, Sjogren, R E, Carson, G R

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The γ and ε Subunits of the CD3 Complex Inhibit Pre-Golgi Degradation of Newly Synthesized T Cell Antigen Receptors by Wileman, Thomas, Carson, Gerald R., Concino, Michael, Ahmed, Asma, Terhorst, Cox

“…The T cell receptor for antigen (TCR) is composed of six different transmembrane proteins. T cells carefully control the intracellular transport of the…”
Get full text

Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum by WILEMAN, T, KANE, L. P, CARSON, G. R, TERHORST, C

“…In this study the effects of A23187 and thapsigargin on the degradation of T-cell antigen receptor-beta (TCR-beta) and CD3-delta in the endoplasmic reticulum…”
Get full text

Recombinant soluble human complement receptor type 1 inhibits inflammation in the reversed passive arthus reaction in rats by Yeh, CG, Marsh, HC, Jr, Carson, GR, Berman, L, Concino, MF, Scesney, SM, Kuestner, RE, Skibbens, R, Donahue, KA, Ip, SH

“…The human CR1 was genetically engineered by site directed mutagenesis into a truncated form which was secreted from transfected Chinese hamster ovary cells…”
Get full text

Cell surface expression of the C3b/C4b receptor (CR1) protects Chinese hamster ovary cells from lysis by human complement by S C Makrides, S M Scesney, P J Ford, K S Evans, G R Carson, H C Marsh, Jr

“…The C3b/C4b receptor, also known as complement receptor type 1 (CR1, CD35), is a single chain glycoprotein consisting of 30 repeating homologous protein…”
Get full text

The transmembrane anchor of the T-cell antigen receptor beta chain contains a structural determinant of pre-Golgi proteolysis by Wileman, T, Carson, G R, Shih, F F, Concino, M F, Terhorst, C

“…Studies with the T-cell antigen receptor (TCR) have shown that the endoplasmic reticulum, or an organelle closely associated with it, can retain and degrade…”
Get full text

Six chains of the human T cell antigen receptor•CD3 complex are necessary and sufficient for processing the receptor heterodimer to the cell surface by CARSON, G. R, KUESTNER, R. E.AHMED A, PETTEY, C. L, CONCINO, M. F

Get full text

The Polite Americans by Carson, Gerald

Get full text

How Old Is "Bourbon"? by Carson, Gerald

Get full text

THE DARK AGE OF AMERICAN DRINKING by CARSON, GERALD

Get full text

Free Show Tonight by Carson, Gerald

Get full text

A testable CMOS asynchronous counter by Carson, G., Borriello, G.

“…A testable design for an asynchronous n-bit CMOS counter is presented, with test inputs that provide full coverage for stuck-at and stuck-open faults. The test…”
Get full text

BLOOMERS AND BREAD CRUMBS by CARSON, GERALD

Get full text