Search Results - "CARRUTHERS, Vern B"

Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress by Huynh, My-Hang, Carruthers, Vern B

“…The Toxoplasma gondii lytic cycle is a repetition of host cell invasion, replication, egress, and re-invasion into the next host cell. While the molecular…”
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The multifaceted interactions between pathogens and host ESCRT machinery by Rivera-Cuevas, Yolanda, Carruthers, Vern B

“…The Endosomal Sorting Complex Required for Transport (ESCRT) machinery consists of multiple protein complexes that coordinate vesicle budding away from the…”
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Tagging of Endogenous Genes in a Toxoplasma gondii Strain Lacking Ku80 by Huynh, My-Hang, Carruthers, Vern B

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Deciphering protein prenylation in endocytic trafficking in Toxoplasma gondii by Carruthers, Vern B, Dou, Zhicheng

“…is a widespread intracellular protozoan pathogen infecting virtually all warm-blooded animals. This parasite acquires host-derived resources to support its…”
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New and emerging uses of CRISPR/Cas9 to genetically manipulate apicomplexan parasites by Di Cristina, Manlio, Carruthers, Vern B

“…Although the application of CRISPR/Cas9 genome engineering approaches was first reported in apicomplexan parasites only 3 years ago, this technology has…”
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Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion by Tomavo, Stanislas, Slomianny, Christian, Meissner, Markus, Carruthers, Vern B

“…Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell…”
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Toxoplasma gondii ingests and digests host cytosolic proteins by Dou, Zhicheng, McGovern, Olivia L, Di Cristina, Manlio, Carruthers, Vern B

“…The protozoan parasite Toxoplasma gondii resides within a nonfusogenic vacuole during intracellular replication. Although the limiting membrane of this vacuole…”
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Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins by Rivera-Cuevas, Yolanda, Mayoral, Joshua, Di Cristina, Manlio, Lawrence, Anna-Lisa E, Olafsson, Einar B, Patel, Romir K, Thornhill, Dishari, Waldman, Benjamin S, Ono, Akira, Sexton, Jonathan Z, Lourido, Sebastian, Weiss, Louis M, Carruthers, Vern B

“…Toxoplasma gondii is a master manipulator capable of effectively siphoning the resources from the host cell for its intracellular subsistence. However, the…”
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Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity by Roiko, Marijo S, Svezhova, Nadezhda, Carruthers, Vern B

“…Pathogenic microbes rely on environmental cues to initiate key events during infection such as differentiation, motility, egress and invasion of cells or…”
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The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii by Aghabi, Dana, Sloan, Megan, Gill, Grace, Hartmann, Elena, Antipova, Olga, Dou, Zhicheng, Guerra, Alfredo J., Carruthers, Vern B., Harding, Clare R.

“…Iron is essential to cells as a cofactor in enzymes of respiration and replication, however without correct storage, iron leads to the formation of dangerous…”
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Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite by Muniz-Feliciano, Luis, Van Grol, Jennifer, Portillo, Jose-Andres C, Liew, Lloyd, Liu, Bing, Carlin, Cathleen R, Carruthers, Vern B, Matthews, Stephen, Subauste, Carlos S

“…Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome…”
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Toxoplasma Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection by Sloves, Pierre-Julien, Delhaye, Stephane, Mouveaux, Thomas, Werkmeister, Elisabeth, Slomianny, Christian, Hovasse, Agnes, Dilezitoko Alayi, Tchilabalo, Callebaut, Isabelle, Gaji, Rajshekhar Y., Schaeffer-Reiss, Christine, Van Dorsselear, Alain, Carruthers, Vern B., Tomavo, Stanislas

“…Apicomplexan parasites have an assortment of unique apical secretory organelles (rhoptries and micronemes), which have crucial functions in host infection…”
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Stable endocytic structures navigate the complex pellicle of apicomplexan parasites by Koreny, Ludek, Mercado-Saavedra, Brandon N., Klinger, Christen M., Barylyuk, Konstantin, Butterworth, Simon, Hirst, Jennifer, Rivera-Cuevas, Yolanda, Zaccai, Nathan R., Holzer, Victoria J. C., Klingl, Andreas, Dacks, Joel B., Carruthers, Vern B., Robinson, Margaret S., Gras, Simon, Waller, Ross F.

“…Apicomplexan parasites have immense impacts on humanity, but their basic cellular processes are often poorly understood. Where endocytosis occurs in these…”
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A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division by Beck, Josh R, Rodriguez-Fernandez, Imilce A, de Leon, Jessica Cruz, Huynh, My-Hang, Carruthers, Vern B, Morrissette, Naomi S, Bradley, Peter J

“…Apicomplexans employ a peripheral membrane system called the inner membrane complex (IMC) for critical processes such as host cell invasion and daughter cell…”
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Functional Dissection of Toxoplasma gondii Perforin-like Protein 1 Reveals a Dual Domain Mode of Membrane Binding for Cytolysis and Parasite Egress by Roiko, Marijo S., Carruthers, Vern B.

“…The recently discovered role of a perforin-like protein (PLP1) for rapid host cell egress by the protozoan parasite Toxoplasma gondii expanded the functional…”
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Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis by Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W, Jones-Brando, Lorraine, Yolken, Robert H, Bordón, Claudia, Charman, Susan A, Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N, Hinrichs, David J, Meunier, Brigitte, Carruthers, Vern B, Riscoe, Michael K

“…Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating ocular and central nervous system disease. We show that the endochin-like…”
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Toxoplasma MIC2 is a major determinant of invasion and virulence by Huynh, My-Hang, Carruthers, Vern B

“…Like its apicomplexan kin, the obligate intracellular protozoan Toxoplasma gondii actively invades mammalian cells and uses a unique form of gliding motility…”
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Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors by Wang, Fengrong, Holmes, Michael J., Hong, Hea Jin, Thaprawat, Pariyamon, Kannan, Geetha, Huynh, My-Hang, Schultz, Tracey L., Licon, M. Haley, Lourido, Sebastian, Dong, Wenzhao, Brito Querido, Jailson, Sullivan, William J., O’Leary, Seán E., Carruthers, Vern B.

“…The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular…”
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Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii by Parussini, Fabiola, Coppens, Isabelle, Shah, Parag P, Diamond, Scott L, Carruthers, Vern B

“…Regulated exocytosis allows the timely delivery of proteins and other macromolecules precisely when they are needed to fulfil their functions. The…”
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TgTKL4 Is a Novel Kinase That Plays an Important Role in Toxoplasma Morphology and Fitness by Montano, Hilary, Anandkrishnan, Ramu, Carruthers, Vern B, Gaji, Rajshekhar Y

“…Protein kinases of the protozoan parasite Toxoplasma gondii have been shown to play key roles in regulating parasite motility, invasion, replication, egress…”
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