Search Results - "CARRETERO, Oscar"

Tubule-vascular feedback in renal autoregulation by Romero, Cesar A, Carretero, Oscar A

“…Afferent arteriole (Af-Art) diameter regulates pressure and flow into the glomerulus, which are the main determinants of the glomerular filtration rate. Thus,…”
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Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction by Peng, Hongmei, Sarwar, Zeyd, Yang, Xiao-Ping, Peterson, Edward L, Xu, Jiang, Janic, Branislava, Rhaleb, Nadia, Carretero, Oscar A, Rhaleb, Nour-Eddine

“…Elevated interleukin-4 (IL-4) levels are associated with cardiac fibrosis in hypertension and heart failure in both patients and experimental animals. We…”
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N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin by Liu, Yun-He, D'Ambrosio, Martin, Liao, Tang-dong, Peng, Hongmei, Rhaleb, Nour-Eddine, Sharma, Umesh, André, Sabine, Gabius, Hans-J, Carretero, Oscar A

“…Galectin-3 (Gal-3) is secreted by activated macrophages. In hypertension, Gal-3 is a marker for hypertrophic hearts prone to develop heart failure. Gal-3…”
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Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats by Cerniello, Flavia M, Silva, Mauro G, Carretero, Oscar A, Gironacci, Mariela M

“…Abstract Aims  Activation of the angiotensin (Ang)-(1-7)/Mas receptor (R) axis protects from sympathetic overactivity. Endocytic trafficking is an essential…”
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Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension by González, Germán E, Rhaleb, Nour-Eddine, D’Ambrosio, Martin A, Nakagawa, Pablo, Liu, Yunhe, Leung, Pablo, Dai, Xiangguo, Yang, Xiao-Ping, Peterson, Edward L, Carretero, Oscar A

“…OBJECTIVE:Inflammation has been proposed as a key component in the development of hypertension and cardiac remodeling associated with different cardiovascular…”
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Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction by Nakagawa, Pablo, Romero, Cesar A, Jiang, Xu, D'Ambrosio, Martin, Bordcoch, Ginette, Peterson, Edward L, Harding, Pamela, Yang, Xiao-Ping, Carretero, Oscar A

“…The natural peptide N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) decreases inflammation in chronic diseases such as hypertension and heart failure. However,…”
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Thymosin β4 Deficiency Exacerbates Renal and Cardiac Injury in Angiotensin-II–Induced Hypertension by Kumar, Nitin, Liao, Tang-Dong, Romero, Cesar A, Maheshwari, Mani, Peterson, Edward L, Carretero, Oscar A

“…Thymosin β4 (Tβ4), a ubiquitous peptide, regulates several cellular processes that include cell morphology, wound healing, and inflammatory response…”
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N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats by González, Germán E, Rhaleb, Nour-Eddine, Nakagawa, Pablo, Liao, Tang-Dong, Liu, Yunhe, Leung, Pablo, Dai, Xiangguo, Yang, Xiao-Ping, Carretero, Oscar A

“…We have reported previously that Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) reduces fibrosis and inflammation (in macrophages and mast cells). However, it…”
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Role of connecting tubule glomerular feedback in obesity related renal damage by Monu, Sumit R, Maheshwari, Mani, Peterson, Edward L, Carretero, Oscar A

“…Zucker obese rats (ZOR) have higher glomerular capillary pressure (P ) that can cause renal damage. P is controlled by afferent (Af-Art) and efferent arteriole…”
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Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis by Zuo, Yiqin, Chun, Bongkwon, Potthoff, Sebastian A, Kazi, Naj, Brolin, Tyler J, Orhan, Diclehan, Yang, Hai-Chun, Ma, Li-Jun, Kon, Valentina, Myöhänen, Timo, Rhaleb, Nour-Eddine, Carretero, Oscar A, Fogo, Agnes B

“…Previously, we found thymosin β4 (Tβ4) is upregulated in glomerulosclerosis and required for angiotensin II-induced expression of plasminogen activator…”
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Angiotensin II-mediated hypertension impairs nitric oxide-induced NKCC2 inhibition in thick ascending limbs by Ramseyer, Vanesa D, Ortiz, Pablo A, Carretero, Oscar A, Garvin, Jeffrey L

“…In thick ascending limbs (THALs), nitric oxide (NO) decreases NaCl reabsorption via cGMP-mediated inhibition of Na-K-2Cl cotransporter (NKCC2). In angiotensin…”
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Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension by González, Germán E, Rhaleb, N-E, D'Ambrosio, Martin A, Nakagawa, Pablo, Liao, Tang-Dong, Peterson, Edward L, Leung, Pablo, Dai, Xiangguo, Janic, Branislava, Liu, Yun-He, Yang, Xiao-Ping, Carretero, Oscar A

“…Galectin-3 (Gal-3), a member of the β-galactoside lectin family, has an important role in immune regulation. In hypertensive rats and heart failure patients,…”
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Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney by Romero, Cesar A, Kumar, Nitin, Nakagawa, Pablo, Worou, Morel E, Liao, Tang-Dong, Peterson, Edward L, Carretero, Oscar A

“…The antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is released from thymosin-β4 (Tβ4) by the meprin-α and prolyl oligopeptidase (POP)…”
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Angiotensin (1-7) Induces Mas Receptor Internalization by Gironacci, Mariela M, Adamo, Hugo P, Corradi, Gerardo, Santos, Robson A, Ortiz, Pablo, Carretero, Oscar A

“…Angiotensin (Ang) (1-7) is the endogenous ligand for the G protein–coupled receptor Mas, a receptor associated with cardiac, renal, and cerebral protective…”
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Heteromerization Between the Bradykinin B2 Receptor and the Angiotensin-(1–7) Mas Receptor: Functional Consequences by Cerrato, Bruno D, Carretero, Oscar A, Janic, Brana, Grecco, Hernán E, Gironacci, Mariela M

“…Bradykinin B2 receptor (B2R) and angiotensin-(1–7) Mas receptor (MasR)–mediated effects are physiologically interconnected. The molecular basis for such cross…”
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A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback by Romero, Cesar A., Carretero, Oscar A.

“…Purpose of Review In this review, we summarized the current knowledge of connecting tubule-glomerular feedback (CTGF), a novel mechanism of renal…”
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Essential hypertension. Part I : Definition and etiology by CARRETERO, O. A, OPARIL, S

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The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase by Kumar, Nitin, Nakagawa, Pablo, Janic, Branislava, Romero, Cesar A, Worou, Morel E, Monu, Sumit R, Peterson, Edward L, Shaw, Jiajiu, Valeriote, Frederick, Ongeri, Elimelda M, Niyitegeka, Jean-Marie V, Rhaleb, Nour-Eddine, Carretero, Oscar A

“…N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural tetrapeptide with anti-inflammatory and antifibrotic properties. Previously, we have shown that…”
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Noninvasive measurement of renal blood flow by magnetic resonance imaging in rats by Romero, Cesar A, Cabral, Glauber, Knight, Robert A, Ding, Guangliang, Peterson, Edward L, Carretero, Oscar A

“…Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling-magnetic resonance imaging (ASL-MRI)…”
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Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage by Sharma, Umesh, Rhaleb, Nour-Eddine, Pokharel, Saraswati, Harding, Pamela, Rasoul, Saman, Peng, Hongmei, Carretero, Oscar A

“…High blood pressure (HBP) is an important risk factor for cardiac, renal, and vascular dysfunction. Excess inflammation is the major pathogenic mechanism for…”
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