Search Results - "CARRELL, Douglas T"

Epigenetics of the male gamete by Carrell, Douglas T., Ph.D., H.C.L.D

“…Objective To review and summarize the current understanding of the epigenetic status of human sperm in regards to protamination, specific localization and…”
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Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis by Hammoud, Saher Sue, Low, Diana H.P., Yi, Chongil, Carrell, Douglas T., Guccione, Ernesto, Cairns, Bradley R.

“…Adult germline stem cells (AGSCs) self-renew (Thy1+ enriched) or commit to gametogenesis (Kit+ enriched). To better understand how chromatin regulates AGSC…”
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A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome by Simon, Luke, Zini, Armand, Dyachenko, Alina, Ciampi, Antonio, Carrell, Douglas

“…Sperm DNA damage is prevalent among infertile men and is known to influence natural reproduction. However, the impact of sperm DNA damage on assisted…”
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Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility by Jenkins, Timothy G, Aston, Kenneth I, Pflueger, Christian, Cairns, Bradley R, Carrell, Douglas T

“…Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders…”
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The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction by James, Emma R, Carrell, Douglas T, Aston, Kenneth I, Jenkins, Timothy G, Yeste, Marc, Salas-Huetos, Albert

“…It is well-established that testicular spermatozoa are immature and acquire motility and fertilization capabilities during transit throughout the epididymis…”
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Distinctive chromatin in human sperm packages genes for embryo development by Carrell, Douglas T, Cairns, Bradley R, Hammoud, Saher Sue, Nix, David A, Zhang, Haiying, Purwar, Jahnvi

“…Because nucleosomes are widely replaced by protamine in mature human sperm, the epigenetic contributions of sperm chromatin to embryo development have been…”
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The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty by Guo, Jingtao, Nie, Xichen, Giebler, Maria, Mlcochova, Hana, Wang, Yueqi, Grow, Edward J., Kim, Robin, Tharmalingam, Melissa, Matilionyte, Gabriele, Lindskog, Cecilia, Carrell, Douglas T., Mitchell, Rod T., Goriely, Anne, Hotaling, James M., Cairns, Bradley R.

“…The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the…”
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Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons by Hendrickson, Peter G, Doráis, Jessie A, Grow, Edward J, Whiddon, Jennifer L, Lim, Jong-Won, Wike, Candice L, Weaver, Bradley D, Pflueger, Christian, Emery, Benjamin R, Wilcox, Aaron L, Nix, David A, Peterson, C Matthew, Tapscott, Stephen J, Carrell, Douglas T, Cairns, Bradley R

“…Bradley Cairns, Douglas Carrell, Stephen Tapscott and colleagues transcriptionally profile human oocytes and preimplantation embryos and highlight DUX4-family…”
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The sperm epigenome and potential implications for the developing embryo by Jenkins, Timothy G, Carrell, Douglas T

“…Recent work in the field of male fertility has yielded significant increases in our understanding of the sperm epigenome and its potential role in embryonic…”
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Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development by Guo, Jingtao, Grow, Edward J., Yi, Chongil, Mlcochova, Hana, Maher, Geoffrey J., Lindskog, Cecilia, Murphy, Patrick J., Wike, Candice L., Carrell, Douglas T., Goriely, Anne, Hotaling, James M., Cairns, Bradley R.

“…Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation…”
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Aberrant sperm DNA methylation predicts male fertility status and embryo quality by Aston, Kenneth I., Ph.D, Uren, Philip J., Ph.D, Jenkins, Timothy G., Ph.D, Horsager, Alan, Ph.D, Cairns, Bradley R., Ph.D, Smith, Andrew D., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate whether male fertility status and/or embryo quality during in vitro fertilization (IVF) therapy can be predicted based on genomewide…”
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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications by Shi, Junchao, Zhang, Yunfang, Tan, Dongmei, Zhang, Xudong, Yan, Menghong, Zhang, Ying, Franklin, Reuben, Shahbazi, Marta, Mackinlay, Kirsty, Liu, Shichao, Kuhle, Bernhard, James, Emma R., Zhang, Liwen, Qu, Yongcun, Zhai, Qiwei, Zhao, Wenxin, Zhao, Linlin, Zhou, Changcheng, Gu, Weifeng, Murn, Jernej, Guo, Jingtao, Carrell, Douglas T., Wang, Yinsheng, Chen, Xuemei, Cairns, Bradley R., Yang, Xiang-lei, Schimmel, Paul, Zernicka-Goetz, Magdalena, Cheloufi, Sihem, Zhang, Ying, Zhou, Tong, Chen, Qi

“…Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA…”
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Paternal germ line aging: DNA methylation age prediction from human sperm by Jenkins, Timothy G, Aston, Kenneth I, Cairns, Bradley, Smith, Andrew, Carrell, Douglas T

“…The relationship between aging and epigenetic profiles has been highlighted in many recent studies. Models using somatic cell methylomes to predict age have…”
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Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility by Hammoud, Saher Sue, B.S, Purwar, Jahnvi, B.S, Pflueger, Christian, M.S, Cairns, Bradley R., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate the associations between proper protamine incorporation and DNA methylation at imprinted loci. Design Experimental research study…”
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Male obesity and alteration in sperm parameters by Hammoud, Ahmad O., M.D, Wilde, Nicole, M.P.H, Gibson, Mark, M.D, Parks, Anna, Carrell, Douglas T., Ph.D, Meikle, A. Wayne, M.D

“…Objective To study the effect of male obesity on sperm parameters and erectile dysfunction. Design Retrospective analysis. Setting Referral fertility center…”
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Subfertility increases risk of testicular cancer: evidence from population-based semen samples by Hanson, Heidi A., Ph.D, Anderson, Ross E., M.D., M.C.R, Aston, Kenneth I., Ph.D, Carrell, Douglas T., Ph.D., H.C.L.D, Smith, Ken R., Ph.D, Hotaling, James M., M.D., MS

“…Objective To further understand the association between semen quality and cancer risk by means of well defined semen parameters. Design Retrospective cohort…”
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Abnormal methylation of the promoter of CREM is broadly associated with male factor infertility and poor sperm quality but is improved in sperm selected by density gradient centrifugation by Nanassy, Laszlo, Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate the methylation status of the promoter of CREM in patients with an abnormal protamine 1/protamine 2 (P1/P2) ratio or oligozoospermia. The…”
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Impact of male obesity on infertility: a critical review of the current literature by Hammoud, Ahmad O., M.D, Gibson, Mark, M.D, Peterson, C. Matthew, M.D, Meikle, A. Wayne, M.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate the current understanding of the effects and potential mechanisms of obesity on male fertility. Design Literature review of articles…”
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Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels by Jenkins, Timothy G., B.S, Aston, Kenneth I., Ph.D, Cairns, Bradley R., Ph.D, Carrell, Douglas T., Ph.D

“…Objective To evaluate the relative intraindividual changes in sperm 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) levels associated with age and…”
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Altered protamine expression and diminished spermatogenesis: what is the link? by Carrell, Douglas T., Emery, Benjamin R., Hammoud, Sue

“…During the elongating spermatid stage of spermiogenesis, human sperm chromatin undergoes a complex transition in which histones are extensively replaced by…”
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