Search Results - "CARRATO, ALFREDO"

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity by Alcalá, Sonia, Sancho, Patricia, Martinelli, Paola, Navarro, Diego, Pedrero, Coral, Martín-Hijano, Laura, Valle, Sandra, Earl, Julie, Rodríguez-Serrano, Macarena, Ruiz-Cañas, Laura, Rojas, Katerin, Carrato, Alfredo, García-Bermejo, Laura, Fernández-Moreno, Miguel Ángel, Hermann, Patrick C., Sainz, Bruno

“…Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells…”
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HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology by Bartley, Angela N, Washington, Mary Kay, Colasacco, Carol, Ventura, Christina B, Ismaila, Nofisat, Benson, 3rd, Al B, Carrato, Alfredo, Gulley, Margaret L, Jain, Dhanpat, Kakar, Sanjay, Mackay, Helen J, Streutker, Catherine, Tang, Laura, Troxell, Megan, Ajani, Jaffer A

“…Context ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with…”
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Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers by Vasen, Hans, Ibrahim, Isaura, Ponce, Carmen Guillen, Slater, Emily P, Matthäi, Elvira, Carrato, Alfredo, Earl, Julie, Robbers, Kristin, van Mil, Anneke M, Potjer, Thomas, Bonsing, Bert A, de Vos Tot Nederveen Cappel, Wouter H, Bergman, Wilma, Wasser, Martin, Morreau, Hans, Klöppel, Günter, Schicker, Christoph, Steinkamp, Martin, Figiel, Jens, Esposito, Irene, Mocci, Evelina, Vazquez-Sequeiros, Enrique, Sanjuanbenito, Alfonso, Muñoz-Beltran, Maria, Montans, José, Langer, Peter, Fendrich, Volker, Bartsch, Detlef K

“…Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Hereditary factors play a role in the development of PDAC in 3% to 5% of all patients…”
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Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance by D’Errico, Gabriele, Alonso-Nocelo, Marta, Vallespinos, Mireia, Hermann, Patrick C., Alcalá, Sonia, García, Coral Pedrero, Martin-Hijano, Laura, Valle, Sandra, Earl, Julie, Cassiano, Chiara, Lombardia, Luis, Feliu, Jaime, Monti, Maria Chiara, Seufferlein, Thomas, García-Bermejo, Laura, Martinelli, Paola, Carrato, Alfredo, Sainz, Bruno

“…Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have…”
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Targeting Tyrosine kinases in Renal Cell Carcinoma: "New Bullets against Old Guys" by Alonso-Gordoa, Teresa, García-Bermejo, María Laura, Grande, Enrique, Garrido, Pilar, Carrato, Alfredo, Molina-Cerrillo, Javier

“…Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths…”
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Tyrosine Kinase Receptors in Oncology by Esteban-Villarrubia, Jorge, Soto-Castillo, Juan José, Pozas, Javier, San Román-Gil, María, Orejana-Martín, Inmaculada, Torres-Jiménez, Javier, Carrato, Alfredo, Alonso-Gordoa, Teresa, Molina-Cerrillo, Javier

“…Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and…”
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Neurologic Toxicity of Immune Checkpoint Inhibitors: A Review of Literature by Albarrán, Víctor, Chamorro, Jesús, Rosero, Diana Isabel, Saavedra, Cristina, Soria, Ainara, Carrato, Alfredo, Gajate, Pablo

“…Immune checkpoint inhibitors have entailed a change of paradigm in the management of multiple malignant diseases and are acquiring a key role in an increasing…”
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Cancer-associated fibroblast-derived gene signatures determine prognosis in colon cancer patients by Herrera, Mercedes, Berral-González, Alberto, López-Cade, Igor, Galindo-Pumariño, Cristina, Bueno-Fortes, Santiago, Martín-Merino, Manuel, Carrato, Alfredo, Ocaña, Alberto, De La Pinta, Carolina, López-Alfonso, Ana, Peña, Cristina, García-Barberán, Vanesa, De Las Rivas, Javier

“…According to the Consensus Molecular Subtype classification (CMS) in CC, the mesenchymal or CMS4 group is characterized by stromal invasion, extracellular…”
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Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance? by Ciernikova, Sona, Earl, Julie, García Bermejo, María Laura, Stevurkova, Viola, Carrato, Alfredo, Smolkova, Bozena

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies due to the rapid rate of metastasis and high resistance to currently…”
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Understanding the molecular-based mechanism of action of the tyrosine kinase inhibitor: sunitinib by Carrato Mena, Alfredo, Grande Pulido, Enrique, Guillén-Ponce, Carmen

“…Sunitinib is an orally available small-molecule multikinase inhibitor. This agent potently inhibits the vascular endothelial growth factor receptor,…”
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Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer by Pineda, Silvia, Real, Francisco X, Kogevinas, Manolis, Carrato, Alfredo, Chanock, Stephen J, Malats, Núria, Van Steen, Kristel

“…Omics data integration is becoming necessary to investigate the genomic mechanisms involved in complex diseases. During the integration process, many…”
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Fluorouracil, Leucovorin, and Irinotecan Plus Either Sunitinib or Placebo in Metastatic Colorectal Cancer: A Randomized, Phase III Trial by Carrato, Alfredo, Swieboda-Sadlej, Anna, Staszewska-Skurczynska, Marzanna, Lim, Robert, Roman, Laslo, Shparyk, Yaroslav, Bondarenko, Igor, Jonker, Derek J, Sun, Yan, De la Cruz, Jhony A, Williams, J Andrew, Korytowsky, Beata, Christensen, James G, Lin, Xun, Tursi, Jennifer M, Lechuga, Maria J, Van Cutsem, Eric

“…This double-blind, phase III study aimed to demonstrate that sunitinib plus FOLFIRI (fluorouracil, leucovorin, and irinotecan) was superior to placebo plus…”
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Targeting Angiogenesis in Pancreatic Neuroendocrine Tumors: Resistance Mechanisms by Pozas, Javier, San Román, María, Alonso-Gordoa, Teresa, Pozas, Miguel, Caracuel, Laura, Carrato, Alfredo, Molina-Cerrillo, Javier

“…Despite being infrequent tumors, the incidence and prevalence of pancreatic neuroendocrine tumors (P-NETs) has been rising over the past few decades. In recent…”
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Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer by Herrera, Mercedes, Llorens, Carlos, Rodríguez, Marta, Herrera, Alberto, Ramos, Ricardo, Gil, Beatriz, Candia, Antonio, Larriba, María Jesús, Garre, Pilar, Earl, Julie, Rodríguez-Garrote, Mercedes, Caldés, Trinidad, Bonilla, Félix, Carrato, Alfredo, García-Barberán, Vanesa, Peña, Cristina

“…Exosome production from cancer-associated fibroblasts seems to be an important driver of tumor progression. We report the first in-depth biotype…”
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Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study by Turner, Michelle C., Gracia‐Lavedan, Esther, Cirac, Marta, Castaño‐Vinyals, Gemma, Malats, Núria, Tardon, Adonina, Garcia‐Closas, Reina, Serra, Consol, Carrato, Alfredo, Jones, Rena R., Rothman, Nathaniel, Silverman, Debra T., Kogevinas, Manolis

“…Although outdoor air pollution and particulate matter in outdoor air have been consistently linked with increased lung cancer risk, the evidence for…”
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Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes by Koutros, Stella, Kogevinas, Manolis, Friesen, Melissa C., Stewart, Patricia A., Baris, Dalsu, Karagas, Margaret R., Schwenn, Molly, Johnson, Alison, Monawar Hosain, G.M., Serra, Consol, Tardon, Adonina, Carrato, Alfredo, Garcia-Closas, Reina, Moore, Lee E., Nickerson, Michael L., Hewitt, Stephen M., Lenz, Petra, Schned, Alan R., Lloreta, Josep, Allory, Yves, Zhang, Haoyu, Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Rothman, Nathaniel, Malats, Núria, Silverman, Debra T.

“…•Risk estimation by quantitative estimates of respirable elemental carbon (diesel)•Heavy diesel exhaust exposure was significantly associated with bladder…”
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Capecitabine as Adjuvant Treatment for Stage III Colon Cancer by Twelves, Chris, Wong, Alfred, Nowacki, Marek P, Abt, Markus, Burris, Howard, Carrato, Alfredo, Cassidy, Jim, Cervantes, Andrés, Fagerberg, Jan, Georgoulias, Vassilis, Husseini, Fares, Jodrell, Duncan, Koralewski, Piotr, Kröning, Hendrik, Maroun, Jean, Marschner, Norbert, McKendrick, Joseph, Pawlicki, Marek, Rosso, Riccardo, Schüller, Johannes, Seitz, Jean-François, Stabuc, Borut, Tujakowski, Jerzy, Van Hazel, Guy, Zaluski, Jerzy, Scheithauer, Werner

“…The standard combination of intravenous fluorouracil plus leucovorin for adjuvant treatment of colon cancer was compared with the oral fluoropyrimidine…”
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Prospective Study of FGFR3 Mutations As a Prognostic Factor in Nonmuscle Invasive Urothelial Bladder Carcinomas by HERNDNDEZ, Silvia, LOPEZ-KNOWLES, Elena, LLORETA, Josep, KOGEVINAS, Manolis, AMOROS, Alex, TARDON, Adonina, CARRATO, Alfredo, SERRA, Consol, MALATS, Nuria, REAL, Francisco X

“…To determine the frequency and the prognostic value of fibroblast growth factor receptor 3 (FGFR3) mutations in patients with nonmuscle invasive bladder tumors…”
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Novel Tyrosine Kinase Targets in Urothelial Carcinoma by Torres-Jiménez, Javier, Albarrán-Fernández, Víctor, Pozas, Javier, Román-Gil, María San, Esteban-Villarrubia, Jorge, Carrato, Alfredo, Rosero, Adriana, Grande, Enrique, Alonso-Gordoa, Teresa, Molina-Cerrillo, Javier

“…Urothelial carcinoma represents one of the most prevalent types of cancer worldwide, and its incidence is expected to grow. Although the treatment of the…”
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Phase III Study of Capecitabine Plus Oxaliplatin Compared With Continuous-Infusion Fluorouracil Plus Oxaliplatin As First-Line Therapy in Metastatic Colorectal Cancer: Final Report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial by DIAZ-RUBIO, Eduardo, TABERNERO, Jose, MAUREL, Joan, GONZALEZ-FLORES, Encarnacion, APARICIO, Jorge, RIVERA, Fernando, LOSA, Ferran, ARANDA, Enrique, GOMEZ-ESPANA, Auxiliadora, MASSUTI, Bartomeu, SASTRE, Javier, CHAVES, Manuel, ABAD, Alberto, CARRATO, Alfredo, QUERALT, Bernardo, REINA, Juan José

“…The aim of this phase III trial was to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) versus Spanish-based continuous-infusion…”
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