Search Results - "CARON, Marc G"

Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery by Slosky, Lauren M., Caron, Marc G., Barak, Lawrence S.

“…G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in the genome and the most successful family of targets of FDA-approved…”
Get full text

New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy by Urs, Nikhil M, Peterson, Sean M, Caron, Marc G

“…Abstract The dopamine D2 receptor (D2 R) is a G protein–coupled receptor that is a common target for antipsychotic drugs. Antagonism of D2 R signaling in the…”
Get full text

Akt/GSK3 Signaling in the Action of Psychotropic Drugs by BEAULIEU, Jean-Martin, GAINETDINOV, Raul R, CARON, Marc G

“…Psychotropic drugs acting on monoamine neurotransmission are major pharmacological treatments for neuropsychiatric conditions such as schizophrenia,…”
Get full text

Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress by Sachs, Benjamin D., Ni, Jason R., Caron, Marc G.

“…Significance The biological factors that determine whether an individual develops mental illness, such as depression or posttraumatic stress disorder, or…”
Get full text

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression by Israelyan, Narek, Del Colle, Andrew, Li, Zhishan, Park, Yeji, Xing, Albert, Jacobsen, Jacob P.R., Luna, Ruth Ann, Jensen, Dane D., Madra, Moneek, Saurman, Virginia, Rahim, Ray, Latorre, Rocco, Law, Kimberly, Carson, William, Bunnett, Nigel W., Caron, Marc G., Margolis, Kara G.

“…Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored. The neurotransmitter serotonin (5-HT) regulates…”
Get full text

The Akt–GSK-3 signaling cascade in the actions of dopamine by Beaulieu, Jean-Martin, Gainetdinov, Raul R, Caron, Marc G

“…Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors…”
Get full text

Rapid Alterations in Corticostriatal Ensemble Coordination during Acute Dopamine-Dependent Motor Dysfunction by Costa, Rui M., Lin, Shih-Chieh, Sotnikova, Tatyana D., Cyr, Michel, Gainetdinov, Raul R., Caron, Marc G., Nicolelis, Miguel A.L.

“…Dopaminergic dysregulation can cause motor dysfunction, but the mechanisms underlying dopamine-related motor disorders remain under debate. We used an…”
Get full text

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability by Hultman, Rainbo, Ulrich, Kyle, Sachs, Benjamin D., Blount, Cameron, Carlson, David E., Ndubuizu, Nkemdilim, Bagot, Rosemary C., Parise, Eric M., Vu, Mai-Anh T., Gallagher, Neil M., Wang, Joyce, Silva, Alcino J., Deisseroth, Karl, Mague, Stephen D., Caron, Marc G., Nestler, Eric J., Carin, Lawrence, Dzirasa, Kafui

“…Brain-wide fluctuations in local field potential oscillations reflect emergent network-level signals that mediate behavior. Cracking the code whereby these…”
Get full text

Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease by Urs, Nikhil M., Bido, Simone, Peterson, Sean M., Daigle, Tanya L., Bass, Caroline E., Gainetdinov, Raul R., Bezard, Erwan, Caron, Marc G.

“…Parkinson’s disease (PD) is characterized by severe locomotor deficits and is commonly treated with the dopamine (DA) precursor l -3,4-dihydroxyphenylalanine (…”
Get full text

Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine by Sutton, Laurie P., Caron, Marc G.

“…The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that is involved in neuronal adaptions that underlie cocaine-induced sensitization and…”
Get full text

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor by Peterson, Sean M., Pack, Thomas F., Wilkins, Angela D., Urs, Nikhil M., Urban, Daniel J., Bass, Caroline E., Lichtarge, Olivier, Caron, Marc G.

“…The neuromodulator dopamine signals through the dopamine D2 receptor (D₂R) to modulate central nervous system functions through diverse signal transduction…”
Get full text

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands by Kapur, Ankur, Zhao, Pingwei, Sharir, Haleli, Bai, Yushi, Caron, Marc G., Barak, Larry S., Abood, Mary E.

“…The cannabinoid receptor 1 (CB1) and CB2 cannabinoid receptors, associated with drugs of abuse, may provide a means to treat pain, mood, and addiction…”
Get full text

Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor by Espinoza, Stefano, Salahpour, Ali, Masri, Bernard, Sotnikova, Tatyana D, Messa, Mirko, Barak, Larry S, Caron, Marc G, Gainetdinov, Raul R

“…The ability of dopamine receptors to interact with other receptor subtypes may provide mechanisms for modulating dopamine-related functions and behaviors. In…”
Get more information

Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics by Masri, Bernard, Salahpour, Ali, Didriksen, Michael, Ghisi, Valentina, Beaulieu, Jean-Martin, Gainetdinov, Raul R, Caron, Marc G

“…Since the unexpected discovery of the antipsychotic activity of chlorpromazine, a variety of therapeutic agents have been developed for the treatment of…”
Get full text

Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease by Fuentes, Romulo, Petersson, Per, Siesser, William B, Caron, Marc G, Nicolelis, Miguel A.L

“…Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term…”
Get full text

Role of GSK3β in behavioral abnormalities induced by serotonin deficiency by Beaulieu, Jean-Martin, Zhang, Xiaodong, Rodriguiz, Ramona M, Sotnikova, Tatyana D, Cools, Michael J, Wetsel, William C, Gainetdinov, Raul R, Caron, Marc G

“…Dysregulation of brain serotonin (5-HT) neurotransmission is thought to underlie mental conditions as diverse as depression, anxiety disorders, bipolar…”
Get full text

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis by Pydi, Sai P., Jain, Shanu, Tung, Wesley, Cui, Yinghong, Zhu, Lu, Sakamoto, Wataru, Jain, Shalini, Abel, Brent S., Skarulis, Monica C., Liu, Jie, Huynh, Thanh, Pacak, Karel, Caron, Marc G., Gavrilova, Oksana, Finkel, Toren, Wess, Jürgen

“…β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes. Their potential roles in regulating adipocyte function in vivo…”
Get full text

Rod Vision Is Controlled by Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA by Herrmann, Rolf, Heflin, Stephanie J., Hammond, Timothy, Lee, Bowa, Wang, Jing, Gainetdinov, Raul R., Caron, Marc G., Eggers, Erika D., Frishman, Laura J., McCall, Maureen A., Arshavsky, Vadim Y.

“…Dark and light adaptation of retinal neurons allow our vision to operate over an enormous light intensity range. Here we report a mechanism that controls the…”
Get full text

Food Reward in the Absence of Taste Receptor Signaling by de Araujo, Ivan E., Oliveira-Maia, Albino J., Sotnikova, Tatyana D., Gainetdinov, Raul R., Caron, Marc G., Nicolelis, Miguel A.L., Simon, Sidney A.

“…Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of…”
Get full text

Establishment of multi-stage intravenous self-administration paradigms in mice by Slosky, Lauren M., Pires, Andrea, Bai, Yushi, Clark, Nicholas B., Hauser, Elizabeth R., Gross, Joshua D., Porkka, Fiona, Zhou, Yang, Chen, Xiaoxiao, Pogorelov, Vladimir M., Toth, Krisztian, Wetsel, William C., Barak, Lawrence S., Caron, Marc G.

“…Genetically tractable animal models provide needed strategies to resolve the biological basis of drug addiction. Intravenous self-administration (IVSA) is the…”
Get full text