Search Results - "CARON, Leslie"

Islet1 cardiovascular progenitors: a single source for heart lineages? by Laugwitz, Karl-Ludwig, Moretti, Alessandra, Caron, Leslie, Nakano, Atsushi, Chien, Kenneth R

“…The creation of regenerative stem cell therapies for heart disease requires that we understand the molecular mechanisms that govern the fates and…”
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A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles by Caron, Leslie, Kher, Devaki, Lee, Kian Leong, McKernan, Robert, Dumevska, Biljana, Hidalgo, Alejandro, Li, Jia, Yang, Henry, Main, Heather, Ferri, Giulia, Petek, Lisa M, Poellinger, Lorenz, Miller, Daniel G, Gabellini, Davide, Schmidt, Uli

“…: Facioscapulohumeral muscular dystrophy (FSHD) represents a major unmet clinical need arising from the progressive weakness and atrophy of skeletal muscles…”
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Anabolic Factors and Myokines Improve Differentiation of Human Embryonic Stem Cell Derived Skeletal Muscle Cells by Ruan, Travis, Harney, Dylan, Koay, Yen Chin, Loo, Lipin, Larance, Mark, Caron, Leslie

“…Skeletal muscle weakness is linked to many adverse health outcomes. Current research to identify new drugs has often been inconclusive due to lack of adequate…”
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Concise Review: Regulation of Embryonic Stem Cell Lineage Commitment by Mitogen‐Activated Protein Kinases by Binétruy, Bernard, Heasley, Lynn, Bost, Frédéric, Caron, Leslie, Aouadi, Myriam

“…Embryonic stem (ES) cells can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell…”
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The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis by BOST, Frédéric, AOUADI, Myriam, LE MARCHAND-BRUSTEL, Yannick, BINETRUY, Bernard, CARON, Leslie, EVEN, Patrick, BELMONTE, Nathalie, PROT, Matthieu, DANI, Christian, HOFMAN, Paul, PAGES, Gilles, POUYSSEGUR, Jacques

“…The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis Frédéric Bost 1 , Myriam Aouadi 1 ,…”
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p38 Mitogen‐Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis by Aouadi, Myriam, Bost, Frédéric, Caron, Leslie, Laurent, Kathiane, Le Marchand Brustel, Yannick, Binétruy, Bernard

“…Mouse embryonic stem (ES) cells can be differentiated, in vitro into a variety of cell types including cardiac cells and neurons. This process is strictly…”
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A new role for the oncogenic high-mobility group A2 transcription factor in myogenesis of embryonic stem cells by CARON, Leslie, BOST, Frédéric, PROT, Matthieu, HOFMAN, Paul, BINETRUY, Bernard

“…The high mobility group type A-2 (HMGA 2) transcription factor is involved in proliferation and differentiation, mainly during embryogenesis. Its activated…”
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Bcl-2 inhibits glucocorticoid-induced apoptosis but only partially blocks calcium ionophore or cycloheximide-regulated apoptosis in S49 cells by Caron-Leslie, L A, Evans, R B, Cidlowski, J A

“…Many non-Hodgkins B-cell lymphomas possess a deregulated bcl-2 gene resulting in a phenotype that is apparently resistant to programmed cell death (apoptosis)…”
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Similar actions of glucocorticoids and calcium on the regulation of apoptosis in S49 cells by Caron-Leslie, L A, Cidlowski, J A

“…Glucocorticoid-induced lymphocyte cell death is a programmed process which is thought to involve the calcium-dependent degradation of DNA into multiples of 180…”
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Marked differences in differentiation propensity among human embryonic stem cell lines by Melton, Douglas A, Osafune, Kenji, Caron, Leslie, Borowiak, Malgorzata, Martinez, Rita J, Fitz-Gerald, Claire S, Sato, Yasunori, Cowan, Chad A, Chien, Kenneth R

“…The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific…”
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Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain by Manion, John, Khuong, Thang, Harney, Dylan, Littleboy, Jamie B., Ruan, Travis, Loo, Lipin, Costigan, Michael, Larance, Mark, Caron, Leslie, Neely, G. Gregory

“…Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory…”
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Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges by Ford, Elizabeth, Pearlman, Jodie, Ruan, Travis, Manion, John, Waller, Matthew, Neely, Gregory G, Caron, Leslie

“…Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal cells and limited regeneration potential of the adult nervous…”
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Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages by Bu, Lei, Martin-Puig, Silvia, Domian, Ibrahim J, Shao, Ying, Roberts, Drucilla J, Jiang, Xin, Chien, Kenneth R, Huang, Paul L, Caron, Leslie, Zhu, Shenjun

“…The generation and expansion of diverse cardiovascular cell lineages is a critical step during human cardiogenesis, with major implications for congenital…”
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I.09 Induced pluripotent stem cells for modeling neuromuscular disorders: development of disease-specific assays, live cells functional testing and drug design by Delourme, M., Laberthonnière, C., Testa, S., Caron, L., Magdinier, F.

“…Induced pluripotent stem cells (iPSC) represent an innovative, easily obtained and renewable stem cell source. This somatic cell-derived model that can be…”
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Multipotent Embryonic Isl1 + Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification by Moretti, Alessandra, Caron, Leslie, Nakano, Atsushi, Lam, Jason T., Bernshausen, Alexandra, Chen, Yinhong, Qyang, Yibing, Bu, Lei, Sasaki, Mika, Martin-Puig, Silvia, Sun, Yunfu, Evans, Sylvia M., Laugwitz, Karl-Ludwig, Chien, Kenneth R.

“…Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells, thought to arise from distinct embryonic precursors. We use genetic…”
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In skeletal muscle and neural crest cells, SMCHD1 regulates biological pathways relevant for Bosma syndrome and facioscapulohumeral dystrophy phenotype by Laberthonnière, Camille, Delourme, Mégane, Chevalier, Raphaël, Dion, Camille, Ganne, Benjamin, Hirst, David, Caron, Leslie, Perrin, Pierre, Adélaïde, José, Chaffanet, Max, Xue, Shifeng, Nguyen, Karine, Reversade, Bruno, Déjardin, Jérôme, Baudot, Anaïs, Robin, Jérôme D, Magdinier, Frédérique

“…Abstract Many genetic syndromes are linked to mutations in genes encoding factors that guide chromatin organization. Among them, several distinct rare genetic…”
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The role of MAPKs in adipocyte differentiation and obesity by Bost, F., Aouadi, M., Caron, L., Binétruy, B.

“…The ERK, p38 and JNK mitogen activated protein kinases (MAPKs) are intracellular signalling pathways that play a pivotal role in many essential cellular…”
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Identification and characterization of glucocorticoid-regulated nuclease(s) in lymphoid cells undergoing apoptosis by Caron-Leslie, L M, Schwartzman, R A, Gaido, M L, Compton, M M, Cidlowski, J A

“…Apoptosis is a physiological process by which selected cells are deleted from a population in response to specific regulatory signals. A hallmark of apoptosis…”
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The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway by Qyang, Yibing, Martin-Puig, Silvia, Chiravuri, Murali, Chen, Shuibing, Xu, Huansheng, Bu, Lei, Jiang, Xin, Lin, Lizhu, Granger, Anne, Moretti, Alessandra, Caron, Leslie, Wu, Xu, Clarke, Jonathan, Taketo, Makoto M, Laugwitz, Karl-Ludwig, Moon, Randall T, Gruber, Peter, Evans, Sylvia M, Ding, Sheng, Chien, Kenneth R

“…Isl1(+) cardiovascular progenitors and their downstream progeny play a pivotal role in cardiogenesis and lineage diversification of the heart. The mechanisms…”
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Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes by Buikema, Jan Willem, Mady, Ahmed S, Mittal, Nikhil V, Atmanli, Ayhan, Caron, Leslie, Doevendans, Pieter A, Sluijter, Joost P G, Domian, Ibrahim J

“…In mammals, cardiac development proceeds from the formation of the linear heart tube, through complex looping and septation, all the while increasing in mass…”
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