Circulating Leptin and Bone Mineral Density in Rheumatoid Arthritis

Circulating Leptin and Bone Mineral Density in Rheumatoid Arthritis

Objective. To evaluate the association between circulating leptin and bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Methods. One-hundred thirty postmenopausal women with RA were assessed for body mass index (BMI), disease characteristics, history of drug use, rheumatoid fact...

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Bibliographic Details
Published in:Journal of rheumatology Vol. 36; no. 3; pp. 512 - 516
Main Authors: ERIKA A. AGUILAR-CHAVEZ, JORGE I. GAMEZ-NAVA, MARIA A. LOPEZ-OLIVO, SILVIA GALVAN-MELENDRES, ESTHER G. CORONA-SANCHEZ, CARLOS A. LOAIZA-CARDENAS, ALFREDO CELIS, ERNESTO G. CARDONA-MUÑOZ, LAURA GONZALEZ-LOPEZ
Format: Journal Article
Language:English
Published: Toronto, ON The Journal of Rheumatology 01-03-2009
Journal of Rheumatology Publishing
Subjects:
Adult
Aged
Arthritis, Rheumatoid - blood
Biological and medical sciences
Bone Density
Cross-Sectional Studies
Diseases of the osteoarticular system
Humans
Inflammatory joint diseases
Investigative techniques, diagnostic techniques (general aspects)
Leptin - blood
Medical sciences
Middle Aged
Osteoarticular system. Muscles
Osteoporosis - blood
Osteoporosis. Osteomalacia. Paget disease
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Statistics, Nonparametric
LEPTIN
Immunopathology
Osteoporosis
Chronic
Rheumatoid arthritis
Diseases of the osteoarticular system
Rheumatology
Autoimmune disease
Inflammatory joint disease
Bone mineral density
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Summary:Objective. To evaluate the association between circulating leptin and bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Methods. One-hundred thirty postmenopausal women with RA were assessed for body mass index (BMI), disease characteristics, history of drug use, rheumatoid factor, and erythrocyte sedimentation rate (ESR). BMD (g/cm 2 ) was determined in the hip and spine by DEXA. Serum leptin concentrations were measured by ELISA. Spearman’s correlation coefficients (rho) were determined between BMD and leptin and other variables. A multiple regression analysis was used to adjust for confounders. Results. Patients’ serum leptin levels varied widely (range 2–128 ng/ml). Thirty-three patients (25%) had osteoporosis. Higher levels of leptin correlated significantly with BMD in the lumbar spine (rho = 0.17, p = 0.04) and total hip (rho = 0.21, p = 0.01). The variables that were negatively correlated with BMD were age, duration of menopause, and ESR. After adjustment for confounders, leptin was no longer associated with BMD. In the multivariate model, factors that remained associated with BMD in the total hip were age (p = 0.021) and BMI (p = 0.003); and the factors that remained associated with BMD in the lumbar spine were BMI (p = 0.03) and ESR (p = 0.01). Conclusion. No relevant association was found between circulating leptin levels and BMD in patients with RA in this cross-sectional study. Followup studies are needed to evaluate whether abnormal leptin levels confer a risk for fractures due to osteoporosis.
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ISSN:0315-162X
1499-2752
DOI:10.3899/jrheum.080196