Search Results - "CARLEN, P. L"

Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation by Derchansky, M., Jahromi, S. S., Mamani, M., Shin, D. S., Sik, A., Carlen, P. L.

“…The neural dynamics and mechanisms responsible for the transition from the interictal to the ictal state (seizures) are unresolved questions in epilepsy. It…”
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Transition to seizure: From “macro”- to “micro”-mysteries by Zhang, Z.J, Valiante, T.A, Carlen, P.L

“…Summary One of the most terrifying aspects of epilepsy is the sudden and apparently unpredictable transition of the brain into the pathological state of an…”
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High frequency stimulation or elevated K+ depresses neuronal activity in the rat entopeduncular nucleus by Shin, D.S, Samoilova, M, Cotic, M, Zhang, L, Brotchie, J.M, Carlen, P.L

“…Abstract High frequency stimulation (HFS) is applied to many brain regions to treat a variety of neurological disorders/diseases, yet the mechanism(s)…”
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Enhanced Ih Depresses Rat Entopeduncular Nucleus Neuronal Activity From High-Frequency Stimulation or Raised Ke by Shin, D. S, Carlen, P. L

“…1 Division of Fundamental Neurobiology, Toronto Western Research Institute, Toronto Western Hospital, University Health Network; and 2 Department of Medicine…”
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Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons by Tymianski, M, Charlton, MP, Carlen, PL, Tator, CH

“…To examine the role of Ca2+ in early neuronal death, we studied the impact of free intracellular calcium concentration ([Ca2+]i) on survivability in…”
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Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation by Tonkikh, A.A, Carlen, P.L

“…Abstract Impaired regulation of presynaptic intracellular calcium is thought to adversely affect synaptic plasticity and cognition in the aged brain. We…”
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The role of altered tissue osmolality on the characteristics and propagation of seizure activity in the intact isolated mouse hippocampus by Shahar, E, Derchansky, M, Carlen, P.L

“…Abstract Objectives To study the role of altered tissue osmolality on the characteristics and propagation dynamics of seizure activity and on interictal…”
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Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy by Frantseva, M.V, Perez Velazquez, J.L, Tsoraklidis, G, Mendonca, A.J, Adamchik, Y, Mills, L.R, Carlen, P.L, Burnham, M.W

“…Reactive oxygen species have been implicated in the development of seizures under pathological conditions and linked to seizure-induced neurodegeneration…”
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Bursting in Inhibitory Interneuronal Networks: A Role for Gap-Junctional Coupling by Skinner, F. K, Zhang, L, Velazquez, J. L. Perez, Carlen, P. L

“…Playfair Neuroscience Unit, The Toronto Hospital Research Institute, Institute of Biomedical Engineering, and Department of Physiology, University of Toronto,…”
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Gap junctions, synchrony and seizures by Perez Velazquez, José Luis, Carlen, Peter L

“…The old concept that the direct intercellular cytoplasmic connections between neurones participate in the coordination of neuronal activity has gained new…”
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L-type calcium channel blockade modifies anesthetic actions on aged hippocampal neurons by El Beheiry, H, Ouanounou, A, Carlen, P.L

“…Abstract Previous studies in our laboratory demonstrated a reversal of anesthetic actions on aged neurons by decreasing extracellular [Ca2+ ] in hippocampal…”
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Upregulation of gap junction connexin 32 with epileptiform activity in the isolated mouse hippocampus by Li, J, Shen, H, Naus, C.C.G, Zhang, L, Carlen, P.L

“…Gap junctions, which serve as intercellular channels providing direct cytoplasmic continuity and ionic current flow between adjacent cells, are constituted by…”
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Slow Oscillations (less than equal to 1 Hz) Mediated by GABAergic Interneuronal Networks in Rat Hippocampus by Zhang, Y, Perez Velazquez, J. L, Tian, G. F, Wu, C.-P, Skinner, F. K, Carlen, P. L, Zhang, L

“…Perfusion of rat brain slices with low millimole CsCl elicits slow oscillations of </=1 Hz in hippocampal CA1 pyramidal neurons. These oscillations are GABAA…”
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Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents by Spigelman, I, Zhang, L, Carlen, P L

“…1. The postnatal development of membrane properties and outward K+ currents in CA1 neurons in rat hippocampal slices was studied with the use of whole-cell…”
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Postnatal development of intrinsic GABAergic rhythms in mouse hippocampus by Wong, T., Zhang, X.L., Asl, M. Nassiri, Wu, C.P., Carlen, P.L., Zhang, L.

“…The local circuitry of the mammalian limbic cortices, including the hippocampus, is capable of generating spontaneous rhythmic activities of 0.5–4Hz when…”
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In vitro recordings of human neocortical oscillations by Florez, C M, McGinn, R J, Lukankin, V, Marwa, I, Sugumar, S, Dian, J, Hazrati, L N, Carlen, P L, Zhang, L, Valiante, T A

“…Electrophysiological oscillations are thought to create temporal windows of communication between brain regions. We show here that human cortical slices…”
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Development of GABA-mediated, chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices by Zhang, L, Spigelman, I, Carlen, P L

“…1. gamma-Aminobutyric acid (GABA)-mediated, Cl(-)-dependent inhibitory postsynaptic potentials (IPSPs) and GABA currents in immature rat hippocampal CA1…”
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Presenilin 1 is Actively Degraded by the 26S Proteasome by Fraser, P.E, Levesque, G, Yu, G, Mills, L.R, Thirlwell, J, Frantseva, M, Gandy, S.E, Seeger, M, Carlen, P.L, St George-Hyslop, P

“…The metabolic pathways governing the turnover of presenilin 1 (PS1) have been incompletely worked out. The PS1 holoprotein has low abundance in many cells and…”
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Hypoglycemia-induced alterations in hippocampal intrinsic rhythms: Decreased inhibition, increased excitation, seizures and spreading depression by Florez, C.M, Lukankin, V, Sugumar, S, McGinn, R, Zhang, Z.J, Zhang, L, Carlen, P.L

“…Abstract Seizures are the most common clinical presentation of severe hypoglycemia, usually as a side effect of insulin treatment for juvenile onset type 1…”
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Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo by Tymianski, M, Wallace, M C, Spigelman, I, Uno, M, Carlen, P L, Tator, C H, Charlton, M P

“…We report the characterization of the first successful treatment of neuronal ischemic injury in vivo by cell-permeant Ca2+ chelators. The chelators attenuated…”
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