Clinical determinants of survival from stage IB cervical cancer in an Inner-City Hospital

This study reviewed a high-risk population of inner-city women with FIGO (International Federation of Gynecologists and Obstetricians) stage Ib cervical cancer diagnosed and treated at a single institution between 1986 and 1993. The patient age at diagnosis averaged 49 years, and most of the patient...

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Bibliographic Details
Published in:	Journal of the National Medical Association Vol. 90; no. 5; pp. 303 - 308
Main Authors:	THOMS, W. W, UNGER, E. R, CARISIO, R, NISENBAUM, R, SPANN, C. O, HOROWITZ, I. R, REEVES, W. C
Format:	Journal Article
Language:	English
Published:	Thorofare, NJ Slack 01-05-1998 Elsevier Limited National Medical Association
Subjects:	Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy African Americans - statistics & numerical data Biological and medical sciences Carcinoma, Adenosquamous - mortality Carcinoma, Adenosquamous - pathology Carcinoma, Adenosquamous - therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cervical cancer Combined Modality Therapy Female Female genital diseases Georgia - epidemiology Gynecology. Andrology. Obstetrics Humans Incidence Medical sciences Middle Aged Neoplasm Staging Poverty Areas Risk Factors Survival Analysis Survival Rate Tumors Urban Population Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy United States North America America Georgia Human Carcinoma Prognosis Stage classification Urban area Malignant tumor Uterine cervix Epidemiology Survival Ethnic group Female genital diseases Risk factor Female Clinical investigation Uterine cervix diseases Public health
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Summary:	This study reviewed a high-risk population of inner-city women with FIGO (International Federation of Gynecologists and Obstetricians) stage Ib cervical cancer diagnosed and treated at a single institution between 1986 and 1993. The patient age at diagnosis averaged 49 years, and most of the patients were black (83%). Squamous carcinomas predominated (75%). Radiotherapy was the most frequent treatment modality (49%), followed by surgery (38%) and combined radiation/surgery (13%). The Kaplan-Meier estimated 4-year survival for all patients completing treatment was 81%. Increased survival was significantly associated with therapy. The Kaplan-Meier estimated survival at 26 months (the time of the last death in radiotherapy patients) was 66% for radiotherapy patients and 100% for those treated with surgery. Radiotherapy patients differed from surgery patients in age, tumor size, and pelvic lymph node status, indicating that treatment selection bias could explain the observed difference in survival. Age, race, histology, and cervical lesion size were not significantly associated with survival.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0027-9684 1943-4693