Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis

Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis

We analyzed 100 control individuals and 60 patients with psoriasis vulgaris from the population of Campinas, Brazil. Typification of class II HLA alleles (HLA-DRB1-5 and -DQB1) was carried out through the DNA/PCR/SSP at medium and high resolution. DNA was extracted through a salting-out procedure: 1...

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Bibliographic Details
Published in:EJD. European journal of dermatology Vol. 15; no. 3; pp. 159 - 163
Main Authors: CARDOSO, Claudia Bueno, UTHIDA-TANAKA, Ana Maria, MAGALHAES, Renata Ferreira, MAGNA, Luiz Alberto, KRAEMER, Maria Helena
Format: Journal Article
Language:English
Published: Montrouge Libbey-Eurotext 01-05-2005
Subjects:
Biological and medical sciences
Brazil - epidemiology
Case-Control Studies
Chi-Square Distribution
Dermatology
Female
Gene Expression Regulation
Genetic Predisposition to Disease - epidemiology
Haplotypes - genetics
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Male
Medical sciences
Polymerase Chain Reaction - methods
Probability
Psoriasis - diagnosis
Psoriasis - genetics
Psoriasis. Parapsoriasis. Lichen
Severity of Illness Index
South America
Brazil
America
Human
Brazilian population
HLA-System
MHC- association
Skin disease
Psoriasis
Dermatology
Major histocompatibility system
DQB genes
Gene
psoriasis vulgaris
triggering factors
Diagnosis
Triggering
Class I histocompatibility antigen
HLA-DRB
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Summary:We analyzed 100 control individuals and 60 patients with psoriasis vulgaris from the population of Campinas, Brazil. Typification of class II HLA alleles (HLA-DRB1-5 and -DQB1) was carried out through the DNA/PCR/SSP at medium and high resolution. DNA was extracted through a salting-out procedure: 13 DRB1 alleles, 3 DRB3 alleles, 1 DRB4 allele, 2 DRB5 alleles, and 5 DQB1 alleles were identified at a medium resolution using the PCR/SSP, and 45 DRB1 alleles were identified at a high resolution in analyzed patients. Results showed associations with psoriasis vulgaris: positive associations HLA-DRB3*02 (p < 0.05, chi(2) = 5.10, RR = 2.14); HLA-DRB1*0102 alleles (p < 0.05, RR = 5.44). Negative associations were found for HLA-DRB4*01 (chi(2) = 3.23, RR = 0.55) and HLA-DRB1*1302 alleles (p < 0.05, RR = 0.23). The haplotypes revealed positive association for HLA-DRB1*0102/DQB1*05 (p < 0.05, RR = 5.44) and HLA-DRB1*0701/DQB1*03 alleles (p < 0.02, RR = 9.00). These findings suggest a possible association of the DRB1 allele with the group of patients showing an early onset of the illness, as well as an association with haplotypes HLA-DRB1*0102/DQB1*05 and HLA-DRB1*0701/DQB1*03.
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ISSN:1167-1122
1952-4013