Search Results - "CARDIN, J"

Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G‑Quadruplex by McQuaid, Kane T, Takahashi, Shuntaro, Baumgaertner, Lena, Cardin, David J, Paterson, Neil G, Hall, James P, Sugimoto, Naoki, Cardin, Christine J

“…The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, consistent with its transient formation in live…”
Get full text

Structural Studies Reveal Enantiospecific Recognition of a DNA G‐Quadruplex by a Ruthenium Polypyridyl Complex by McQuaid, Kane, Abell, Holly, Gurung, Sarah P., Allan, David R., Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J., Hall, James P.

“…By using X‐ray crystallography, we show that the complexes Λ/Δ‐[Ru(TAP)2(11‐CN‐dppz)]2+ (TAP=1,4,5,8‐tetraazaphenanthrene, dppz=dipyridophenazine) bind DNA…”
Get full text

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior by Carlén, M, Meletis, K, Siegle, J H, Cardin, J A, Futai, K, Vierling-Claassen, D, Rühlmann, C, Jones, S R, Deisseroth, K, Sheng, M, Moore, C I, Tsai, L-H

“…Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive…”
Get full text

X‐ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru‐dppz Complexes by McQuaid, Kane, Hall, James P., Brazier, John A., Cardin, David J., Cardin, Christine J.

“…The new complexes [Ru(TAP)2(11‐CN‐dppz)]2+, [Ru(TAP)2(11‐Br‐dppz)]2+and [Ru(TAP)2(11,12‐diCN‐dppz)]2+ are reported. The addition of nitrile substituents to the…”
Get full text

Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy by Hall, James P., Poynton, Fergus E., Keane, Páraic M., Gurung, Sarah P., Brazier, John A., Cardin, David J., Winter, Graeme, Gunnlaugsson, Thorfinnur, Sazanovich, Igor V., Towrie, Michael, Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve…”
Get full text

Interactions of small molecules with DNA junctions by McQuaid, Kane T, Pipier, Angélique, Cardin, Christine J, Monchaud, David

“…The four natural DNA bases (A, T, G and C) associate in base pairs (A=T and G≡C), allowing the attached DNA strands to assemble into the canonical double helix…”
Get full text

Photochemically active DNA-intercalating ruthenium and related complexes - insights by combining crystallography and transient spectroscopy by Cardin, Christine J, Kelly, John M, Quinn, Susan J

“…Recent research on the study of the interaction of ruthenium polypyridyl compounds and defined sequence nucleic acids is reviewed. Particular emphasis is paid…”
Get full text

Cover Picture: Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)2phi]2+ (Angew. Chem. Int. Ed. 13/2024) by Prieto Otoya, Tayler D., McQuaid, Kane T., Hennessy, Joseph, Menounou, Georgia, Gibney, Alex, Paterson, Neil G., Cardin, David J., Kellett, Andrew, Cardin, Christine J.

“…DNA binding by intercalation , showing both sequence and enantiospecificity, of a ruthenium diimine complex, is reported by Christine Cardin, Andrew Kellett et…”
Get full text

Correction: Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch by Prieto Otoya, Tayler D, McQuaid, Kane T, Paterson, Neil G, Cardin, David J, Kellett, Andrew, Cardin, Christine J

“…[This corrects the article DOI: 10.1039/D4SC01448K.]…”
Get full text

The importance of loop length on the stability of i-motif structures by Gurung, Sarah P, Schwarz, Christine, Hall, James P, Cardin, Christine J, Brazier, John A

“…Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to…”
Get more information

Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ‐[Ru(phen)2phi]2 by Prieto Otoya, Tayler D., McQuaid, Kane T., Hennessy, Joseph, Menounou, Georgia, Gibney, Alex, Paterson, Neil G., Cardin, David J., Kellett, Andrew, Cardin, Christine J.

“…The grooves of DNA provide recognition sites for many nucleic acid binding proteins and anticancer drugs such as the covalently binding cisplatin. Here we…”
Get full text

Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch by Prieto Otoya, Tayler D, McQuaid, Kane T, Paterson, Neil G, Cardin, David J, Kellett, Andrew, Cardin, Christine J

“…We report a crystal structure at atomic resolution (0.9 Å) of a ruthenium complex bound to a consecutive DNA double mismatch, which results in a TA basepair…”
Get full text

X‑ray Crystal Structure of rac-[Ru(phen)2dppz]2+ with d(ATGCAT)2 Shows Enantiomer Orientations and Water Ordering by Hall, James P, Cook, Daniel, Morte, Sara Ruiz, McIntyre, Patrick, Buchner, Katrin, Beer, Hanna, Cardin, David J, Brazier, John A, Winter, Graeme, Kelly, John M, Cardin, Christine J

“…We report an atomic resolution X-ray crystal structure containing both enantiomers of rac-[Ru(phen)2dppz]2+ with the d(ATGCAT)2 DNA duplex (phen =…”
Get full text

Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes by Hall, James P, Keane, Páraic M, Beer, Hanna, Buchner, Katrin, Winter, Graeme, Sorensen, Thomas L, Cardin, David J, Brazier, John A, Cardin, Christine J

“…[Ru(phen) (dppz)] has been studied since the 1990s due to its 'light-switch' properties. It can be used as a luminescent DNA probe, with emission switched on…”
Get full text

Controlled Dehydration of a Ruthenium Complex–DNA Crystal Induces Reversible DNA Kinking by Hall, James. P, Sanchez-Weatherby, Juan, Alberti, Cora, Quimper, Caroline Hurtado, O’Sullivan, Kyra, Brazier, John. A, Winter, Graeme, Sorensen, Thomas, Kelly, John M, Cardin, David. J, Cardin, Christine J

“…Hydration-dependent DNA deformation has been known since Rosalind Franklin recognized that the relative humidity of the sample had to be maintained to observe…”
Get full text

Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)(dppz)] light-switch compound in solution and when bound to DNA by Poynton, Fergus E, Hall, James P, Keane, Páraic M, Schwarz, Christine, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Cardin, Christine J, Cardin, David J, Quinn, Susan J, Long, Conor, Kelly, John M

“…The [Ru(phen) 2 (dppz)] 2+ complex ( 1 ) is non-emissive in water but is highly luminescent in organic solvents or when bound to DNA, making it a useful probe…”
Get full text

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand by Hall, James P, O’Sullivan, Kyra, Naseer, Abeer, Smith, Jayden A, Kelly, John M, Cardin, Christine J

“…We describe a crystal structure, at atomic resolution (1.1 Å, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a…”
Get full text

Approximating the coalescent with recombination by McVean, Gilean A.T, Cardin, Niall J

“…The coalescent with recombination describes the distribution of genealogical histories and resulting patterns of genetic variation in samples of DNA sequences…”
Get full text

Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen) 2 (dppz)] 2+ light-switch compound in solution and when bound to DNA by Poynton, Fergus E, Hall, James P, Keane, Páraic M, Schwarz, Christine, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Cardin, Christine J, Cardin, David J, Quinn, Susan J, Long, Conor, Kelly, John M

“…The [Ru(phen) (dppz)] complex ( ) is non-emissive in water but is highly luminescent in organic solvents or when bound to DNA, making it a useful probe for DNA…”
Get full text

The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru–dppz Complexes to DNA by Hall, James P, Beer, Hanna, Buchner, Katrin, Cardin, David J, Cardin, Christine J

“…Polypyridyl ruthenium complexes have been intensively studied and possess photophysical properties that are both interesting and useful. They can act as probes…”
Get full text